Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00029029.xml
J Pediatr Intensive Care 2019; 08(02): 092-095
DOI: 10.1055/s-0038-1668603
DOI: 10.1055/s-0038-1668603
Case Report
Posterior Reversible Encephalopathy Syndrome Complicating Ruptured Appendicitis and Abscess Drainage in a Previously Healthy Pediatric Patient
Further Information
Publication History
10 June 2018
17 July 2018
Publication Date:
22 August 2018 (online)

Abstract
In this study, we present the youngest reported case of posterior reversible encephalopathy syndrome (PRES) in the United States, which developed following perforated appendicitis with subsequent peritonitis and intra-abdominal abscess formation. Additionally, we discuss potential physiological factors contributing to her acute neurological deterioration and resultant cerebral vasogenic edema.
-
References
- 1 Hinchey J, Chaves C, Appignani B. , et al. A reversible posterior leukoencephalopathy syndrome. N Engl J Med 1996; 334 (08) 494-500
- 2 Ettinger N, Pearson M, Lamb FS, Wellons III JC. Pediatric posterior reversible encephalopathy syndrome presenting with isolated cerebellar edema and obstructive hydrocephalus. J Neurosurg Pediatr 2014; 14 (04) 344-347
- 3 Raj S, Overby P, Erdfarb A, Ushay HM. Posterior reversible encephalopathy syndrome: incidence and associated factors in a pediatric critical care population. Pediatr Neurol 2013; 49 (05) 335-339
- 4 Bartynski WS. Posterior reversible encephalopathy syndrome, part 1: fundamental imaging and clinical features. Am J Neuroradiol 2008; 29 (06) 1036-1042
- 5 Bolton SJ, Anthony DC, Perry VH. Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo. Neuroscience 1998; 86 (04) 1245-1257
- 6 Pfister D, Siegemund M, Dell-Kuster S. , et al. Cerebral perfusion in sepsis-associated delirium. Crit Care 2008; 12 (03) R63
- 7 Vallet B. Bench-to-bedside review: endothelial cell dysfunction in severe sepsis: a role in organ dysfunction?. Crit Care 2003; 7 (02) 130-138
- 8 Fugate JE, Rabinstein AA. Posterior reversible encephalopathy syndrome: clinical and radiological manifestations, pathophysiology, and outstanding questions. Lancet Neurol 2015; 14 (09) 914-925
- 9 Vavilala MS, Newell DW, Junger E. , et al. Dynamic cerebral autoregulation in healthy adolescents. Acta Anaesthesiol Scand 2002; 46 (04) 393-397
- 10 Siebert E, Bohner G, Endres M, Liman TG. Clinical and radiological spectrum of posterior reversible encephalopathy syndrome: does age make a difference?--A retrospective comparison between adult and pediatric patients. PLoS One 2014; 9 (12) e115073
- 11 Zheng W. Neurotoxicology of the brain barrier system: new implications. J Toxicol Clin Toxicol 2001; 39 (07) 711-719