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DOI: 10.1055/s-0038-1669420
Prognostic Factors in Paranasal Sinus Squamous Cell Carcinoma and Adenocarcinoma: A SEER Database Analysis
Publikationsverlauf
10. Dezember 2017
07. Juli 2018
Publikationsdatum:
24. August 2018 (online)
![](https://www.thieme-connect.de/media/jnlsb/201903/lookinside/thumbnails/10-1055-s-0038-1669420_170210-1.jpg)
Abstract
Background Outcome studies on sinonasal malignancy are limited to retrospective case series, often with inclusion of diverse histology and short follow-up. The objective of this study was to identify key predictive variables that independently impact survival for paranasal sinus squamous cell carcinoma (SCC) and adenocarcinoma (AC) and to compare these variables in the context of these two distinct clinicopathologic entities.
Methods: Analysis was conducted using the Surveillance, Epidemiology, and End Results database from 1973 to 2012 to identify key variables that impact survival for SCC and AC.
Results A total of 3,714 cases were included. There were 2,895 SCC cases and 819 AC cases. The mean age at diagnosis was 64.1 years. The male to female ratio for SCC and AC was 1.85 and 1.04, respectively. Patients with SCC and AC were most often diagnosed with stage IV disease in 61.8 and 63.4% of cases, respectively. The majority of patients received combined surgery and radiation (52% for SCC and 43.1% for AC). For SCC, increased age (p < 0.001) and stage (p < 0.001) were negative predictors, and surgery improved survival (p < 0.001) on multivariate analysis. For AC, prognostic factors associated with worse survival include increased age (p < 0.001) and grade (p < 0.001) on multivariate analysis. Overall survival was significantly higher in AC compared with SCC at 5 years (p = 0.001).
Conclusion SCC and AC of the paranasal sinuses are both aggressive malignancies with poor survival. For both histological subtypes, increased age predicts worse survival and grade also closely links to survival in AC. These data have important potential implications for treatment planning and pretreatment counseling.
Keywords
sinonasal - carcinoma - squamous cell carcinoma - adenocarcinoma - outcomes - prognostic factorsNote
This study was presented as a poster presentation at the ARS 61st Annual Meeting, September 25–26, 2015, in Dallas, Texas, United States.
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References
- 1 Banuchi V, Mallen J, Kraus D. Cancers of the nose, sinus, and skull base. Surg Oncol Clin N Am 2015; 24 (03) 563-577
- 2 Turner JH, Reh DD. Incidence and survival in patients with sinonasal cancer: a historical analysis of population-based data. Head Neck 2012; 34 (06) 877-885
- 3 Llorente JL, López F, Suárez C, Hermsen MA. Sinonasal carcinoma: clinical, pathological, genetic and therapeutic advances. Nat Rev Clin Oncol 2014; 11 (08) 460-472
- 4 Jackson RT, Fitz-Hugh GS, Constable WC. Malignant neoplasms of the nasal cavities and paranasal sinuses: (a retrospective study). Laryngoscope 1977; 87 (5 Pt 1): 726-736
- 5 Sisson Sr GA, Toriumi DM, Atiyah RA. Paranasal sinus malignancy: a comprehensive update. Laryngoscope 1989; 99 (02) 143-150
- 6 Bossi P, Saba NF, Vermorken JB. , et al. The role of systemic therapy in the management of sinonasal cancer: a critical review. Cancer Treat Rev 2015; 41 (10) 836-843
- 7 Bhattacharyya N. Cancer of the nasal cavity: survival and factors influencing prognosis. Arch Otolaryngol Head Neck Surg 2002; 128 (09) 1079-1083
- 8 Roush GC. Epidemiology of cancer of the nose and paranasal sinuses: current concepts. Head Neck Surg 1979; 2 (01) 3-11
- 9 Unsal AA, Dubal PM, Patel TD. , et al. Squamous cell carcinoma of the nasal cavity: a population-based analysis. Laryngoscope 2016; 126 (03) 560-565
- 10 Surveillance, Epidemiology, and End Results (SEER) Program. SEER*Stat Database: Incidence - SEER 9 Regs Research Data, Nov 2011 Sub (1973–2009) <Katrina/Rita Population Adjustment> - Linked To County Attributes - Total U.S., 1969–2010 Counties, National Cancer Institute, DCCPS, Surveillance Research Program, Surveillance Systems Branch, released April 2012, based on the November 2011 submission. Available at: www.seer.cancer.gov . Accessed July 15, 2016
- 11 Harvey RJ, Dalgorf DM. Chapter 10: sinonasal malignancies. Am J Rhinol Allergy 2013; 27 (Suppl 1): S35-38
- 12 Ansa B, Goodman M, Ward K. , et al. Paranasal sinus squamous cell carcinoma incidence and survival based on Surveillance, Epidemiology, and End Results data, 1973 to 2009. Cancer 2013; 119 (14) 2602-2610
- 13 Haerle SK, Gullane PJ, Witterick IJ, Zweifel C, Gentili F. Sinonasal carcinomas: epidemiology, pathology, and management. Neurosurg Clin N Am 2013; 24 (01) 39-49
- 14 Nishimura G, Tsukuda M, Mikami Y. , et al. The efficacy and safety of concurrent chemoradiotherapy for maxillary sinus squamous cell carcinoma patients. Auris Nasus Larynx 2009; 36 (05) 547-554
- 15 Sato Y, Morita M, Takahashi HO, Watanabe N, Kirikae I. Combined surgery, radiotherapy, and regional chemotherapy in carcinoma of the paranasal sinuses. Cancer 1970; 25 (03) 571-579
- 16 Dubal PM, Bhojwani A, Patel TD. , et al. Squamous cell carcinoma of the maxillary sinus: a population-based analysis. Laryngoscope 2016; 126 (02) 399-404
- 17 Bhattacharyya N. Factors predicting survival for cancer of the ethmoid sinus. Am J Rhinol 2002; 16 (05) 281-286
- 18 Bhojwani A, Unsal A, Dubal PM. , et al. Frontal sinus malignancies: a population-based analysis of incidence and survival. Otolaryngol Head Neck Surg 2016; 154 (04) 735-741
- 19 Ghosh R, Dubal PM, Chin OY. , et al. Sphenoid sinus malignancies: a population-based comprehensive analysis. Int Forum Allergy Rhinol 2016; 6 (07) 752-759
- 20 Michel J, Fakhry N, Mancini J. , et al. Sinonasal squamous cell carcinomas: clinical outcomes and predictive factors. Int J Oral Maxillofac Surg 2014; 43 (01) 1-6
- 21 Danesh-Sani SA, Sarafraz A, Chamani M, Derakhshandeh H. Paranasal sinuses malignancies: a 12-year review of clinical characteristics. Med Oral Patol Oral Cir Bucal 2016; 21 (05) e626-e630
- 22 Wood JW, Eloy JA, Vivero RJ. , et al. Efficacy of transnasal endoscopic resection for malignant anterior skull-base tumors. Int Forum Allergy Rhinol 2012; 2 (06) 487-495
- 23 Dulguerov P, Jacobsen MS, Allal AS, Lehmann W, Calcaterra T. Nasal and paranasal sinus carcinoma: are we making progress? A series of 220 patients and a systematic review. Cancer 2001; 92 (12) 3012-3029
- 24 Leivo I. Sinonasal adenocarcinoma: update on classification, immunophenotype and molecular features. Head Neck Pathol 2016; 10 (01) 68-74
- 25 Poizat F, Gonzalez AM, Raynaud P. , et al. Adenocarcinomas of nasal cavities and paranasal sinuses: diagnostic pitfalls in sinonasal glandular lesions [in French]. Ann Pathol 2009; 29 (04) 286-295
- 26 Leivo I. Update on sinonasal adenocarcinoma: classification and advances in immunophenotype and molecular genetic make-up. Head Neck Pathol 2007; 1 (01) 38-43
- 27 Ganly I, Patel SG, Singh B. , et al. Craniofacial resection for malignant paranasal sinus tumors: report of an International Collaborative Study. Head Neck 2005; 27 (07) 575-584