Long-Term Effect of Lactation on Maternal Cardiovascular Function and Adiposity in a Murine Model

Sandra R. Herrera; Kathleen L. Vincent; Aaron Poole; Gayle Olson; Igor Patrikeev; Jamal Saada; Phyllis Gamble; Massoud Motamedi; George R. Saade; Alison M. Stuebe; Egle Bytautiene Prewit

doi:10.1055/s-0038-1669443

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol 2019; 36(05): 490-497
DOI: 10.1055/s-0038-1669443

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Long-Term Effect of Lactation on Maternal Cardiovascular Function and Adiposity in a Murine Model

Sandra R. Herrera

¹Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas

,

Kathleen L. Vincent

²Division of Gynecology, Department of Obstetrics and Gynecology, Center for Biomedical Engineering, University of Texas Medical Branch, Galveston, Texas

,

Aaron Poole

¹Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas

,

Gayle Olson

¹Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas

,

Igor Patrikeev

³Center for Biomedical Engineering, University of Texas Medical Branch, Galveston, Texas

,

Jamal Saada

³Center for Biomedical Engineering, University of Texas Medical Branch, Galveston, Texas

,

Phyllis Gamble

¹Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas

,

Massoud Motamedi

³Center for Biomedical Engineering, University of Texas Medical Branch, Galveston, Texas

,

George R. Saade

¹Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas

,

Alison M. Stuebe

⁴Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina

⁵Department of Maternal and Child Health, University of North Carolina Gillings School of Public Health, Chapel Hill, North Carolina

,

Egle Bytautiene Prewit

¹Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas

› Institutsangaben

Abstract

Objective Epidemiological studies suggest that lactation is associated with long-term maternal health benefits. To avoid confounders in human studies, we used a previously characterized murine model to investigate the long-term effect of lactation on both cardiovascular function and adiposity.

Study Design After the delivery of the pups, CD-1 female mice were randomly divided into two groups: lactated and nonlactated (NL). Before pregnancy and at 9 months postdelivery, blood pressure was measured using a tail cuff, visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were assessed by computed tomography (CT), echocardiography was performed using microultrasound, and cholesterol panels and fasting blood glucose were measured. The data were analyzed using Student's t-test (significance at p < 0.05).

Results There were no differences in baseline parameters between the two groups. At 9 months postdelivery, the NL group weighed significantly more (p = 0.03) and demonstrated a significantly lower cardiac output (p = 0.05) and ejection fraction (p = 0.03). The mice in the NL group also had higher VAT (p < 0.01) and SAT percentiles (p = 0.03). Fasting glucose (p = 0.01) and low-density lipoprotein (p = 0.01) were significantly higher in the NL group at 9 months.

Conclusion Our results show the benefit of lactation is not just limited to the immediate postpartum period but it also extends into midlife in a murine model.

Keywords

adipose tissue - blood pressure - CD-1 mice - lactation - long-term effect

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Referenzen

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