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CC BY-NC-ND 4.0 · Journal of Morphological Sciences 2018; 35(02): 096-101
DOI: 10.1055/s-0038-1669470
Review Article
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Testosterone Administration Alters Hepatic Blood Flow Across Age: Systematic Review of Animal Experimental Studies

Ricardo Aparecido Baptista Nucci
1   Aging Studies Program (MS), Universidade São Judas Tadeu, São Paulo, SP, Brazil
2   Laboratory of Morphoquantitative Studies and Immunohistochemistry, Department of Aging Sciences, Universidade São Judas Tadeu, São Paulo, SP, Brazil
,
Valéria Simões Tanasov
2   Laboratory of Morphoquantitative Studies and Immunohistochemistry, Department of Aging Sciences, Universidade São Judas Tadeu, São Paulo, SP, Brazil
,
Walter Krause Neto
3   Laboratory of Morphoquantitative Studies and Immunohistochemistry, Department of Physical Education, Universidade São Judas Tadeu, São Paulo, SP, Brazil
,
Romeu Rodrigues de Souza
2   Laboratory of Morphoquantitative Studies and Immunohistochemistry, Department of Aging Sciences, Universidade São Judas Tadeu, São Paulo, SP, Brazil
3   Laboratory of Morphoquantitative Studies and Immunohistochemistry, Department of Physical Education, Universidade São Judas Tadeu, São Paulo, SP, Brazil
,
Eliane Florencio Gama
1   Aging Studies Program (MS), Universidade São Judas Tadeu, São Paulo, SP, Brazil
2   Laboratory of Morphoquantitative Studies and Immunohistochemistry, Department of Aging Sciences, Universidade São Judas Tadeu, São Paulo, SP, Brazil
3   Laboratory of Morphoquantitative Studies and Immunohistochemistry, Department of Physical Education, Universidade São Judas Tadeu, São Paulo, SP, Brazil
› Author Affiliations
Further Information

Publication History

06 April 2017

03 August 2018

Publication Date:
31 August 2018 (online)

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Abstract

Testosterone levels decline gradually with advancing age. At this point, testosterone administration as a therapy has been largely used to improve different outcomes. However, testosterone induces dose-dependent negative effects on the structure and function of the liver across age. Therefore, the present study aimed to carry out a systematic review of the effects of testosterone administration on the hepatic structure of adult and aged animals. We have searched the PubMed, Google Scholar, Science Direct, Scielo and Lilacs databases for animal experimental studies on the effects of testosterone administration on the hepatic structure across age. After applying the inclusion and exclusion criteria, we included two articles in a systematic review and meta-analysis (regarding adult/aged rats). We have shown through a systematic review with meta-analysis that testosterone may cause chronic hepatic congestion. However, the present review had a small number of studies, which was considered a limitation. At this point, we encourage the development of more studies to elucidate the cellular and molecular mechanisms involved in hepatic injuries, as well as the hepatic metabolism of exogenous testosterone across age.

Keywords

aging - liver - hepatic structure - testosterone - androgenic anabolic steroids - review
 

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