Testosterone Administration Alters Hepatic Blood Flow Across Age: Systematic Review of Animal Experimental Studies

Ricardo Aparecido Baptista Nucci; Valéria Simões Tanasov; Walter Krause Neto; Romeu Rodrigues de Souza; Eliane Florencio Gama

doi:10.1055/s-0038-1669470

Journal of Morphological Sciences, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Journal of Morphological Sciences 2018; 35(02): 096-101
DOI: 10.1055/s-0038-1669470

Review Article

Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Testosterone Administration Alters Hepatic Blood Flow Across Age: Systematic Review of Animal Experimental Studies

Ricardo Aparecido Baptista Nucci

¹Aging Studies Program (MS), Universidade São Judas Tadeu, São Paulo, SP, Brazil

²Laboratory of Morphoquantitative Studies and Immunohistochemistry, Department of Aging Sciences, Universidade São Judas Tadeu, São Paulo, SP, Brazil

,

Valéria Simões Tanasov

²Laboratory of Morphoquantitative Studies and Immunohistochemistry, Department of Aging Sciences, Universidade São Judas Tadeu, São Paulo, SP, Brazil

,

Walter Krause Neto

³Laboratory of Morphoquantitative Studies and Immunohistochemistry, Department of Physical Education, Universidade São Judas Tadeu, São Paulo, SP, Brazil

,

Romeu Rodrigues de Souza

²Laboratory of Morphoquantitative Studies and Immunohistochemistry, Department of Aging Sciences, Universidade São Judas Tadeu, São Paulo, SP, Brazil

³Laboratory of Morphoquantitative Studies and Immunohistochemistry, Department of Physical Education, Universidade São Judas Tadeu, São Paulo, SP, Brazil

,

Eliane Florencio Gama

¹Aging Studies Program (MS), Universidade São Judas Tadeu, São Paulo, SP, Brazil

²Laboratory of Morphoquantitative Studies and Immunohistochemistry, Department of Aging Sciences, Universidade São Judas Tadeu, São Paulo, SP, Brazil

³Laboratory of Morphoquantitative Studies and Immunohistochemistry, Department of Physical Education, Universidade São Judas Tadeu, São Paulo, SP, Brazil

› Institutsangaben

Abstract

Testosterone levels decline gradually with advancing age. At this point, testosterone administration as a therapy has been largely used to improve different outcomes. However, testosterone induces dose-dependent negative effects on the structure and function of the liver across age. Therefore, the present study aimed to carry out a systematic review of the effects of testosterone administration on the hepatic structure of adult and aged animals. We have searched the PubMed, Google Scholar, Science Direct, Scielo and Lilacs databases for animal experimental studies on the effects of testosterone administration on the hepatic structure across age. After applying the inclusion and exclusion criteria, we included two articles in a systematic review and meta-analysis (regarding adult/aged rats). We have shown through a systematic review with meta-analysis that testosterone may cause chronic hepatic congestion. However, the present review had a small number of studies, which was considered a limitation. At this point, we encourage the development of more studies to elucidate the cellular and molecular mechanisms involved in hepatic injuries, as well as the hepatic metabolism of exogenous testosterone across age.

Keywords

aging - liver - hepatic structure - testosterone - androgenic anabolic steroids - review

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References
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