Molekulare Allergologie

Zusammenfassung

Die molekulare Allergiediagnostik kann die Bildung von allergenspezifischem IgE gegen einzelne Komponenten eines nativen Allergens nachweisen. Sie stellt somit eine Erweiterung der klassischen extraktbasierten Allergiediagnostik dar. Durch eine solche komponentenbasierte Diagnostik kann es gelingen, Reaktionsmuster eines Patienten zu identifizieren, die mit einem unterschiedlichen Schweregrad oder Risiko bestimmter allergischer Reaktionen einhergehen. Klinisch-epidemiologische Studien deuten außerdem an, dass komponentenbasierte Reaktionsmuster möglichweise auch helfen können, Therapieansprechen und/oder Krankheitsverläufe besser einzuschätzen.

Summary

Molecular allergy diagnostics can detect the formation of allergen-specific IgE against individual components of a native allergen. It thus represents an extension of classical extract-based allergy diagnostics. Such component-based diagnostics can be used to identify patient reaction patterns associated with a different severity or risk of certain allergic reactions. Clinical epidemiological studies also suggest that component-based response patterns may help to better assess treatment response and/or disease progression.

Schlüsselwörter

Allergie - IgE-Antikörper - molekular - komponentenbasierte Diagnostik

Keywords

Allergy - IgE antibodies - molecular - component-resolved diagnostics

• Literatur

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