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Am J Perinatol 2019; 36(06): 600-608
DOI: 10.1055/s-0038-1672141
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Role of Umbilical Cord Blood Concentration of IGF-I, IGF-II, Leptin, Adiponectin, Ghrelin, Resistin, and Visfatin in Fetal Growth

Emine Esin Yalinbas
1   Division of Neonatology, Dumlupınar University School of Medicine, Kutahya, Turkey
,
Cigdem Binay
2   Department of Pediatric Endocrinology, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey
,
Enver Simsek
2   Department of Pediatric Endocrinology, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey
,
Mehmet Arif Aksit
3   Division of Neonatology, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey
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Publikationsverlauf

12. April 2018

14. August 2018

Publikationsdatum:
03. Oktober 2018 (online)

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Abstract

Objective Herein, we measured the concentration of insulinlike growth factor I (IGF-I), IGF-II, leptin, adiponectin, ghrelin, resistin, and visfatin in the umbilical cord blood of newborns categorized as “small for gestational age” (SGA), “appropriate for gestational age” (AGA), and “large for gestational age” (LGA). Our aim was to elucidate the link between the levels of these proteins and fetal growth.

Study Design A total of 96 term infants were included and categorized into three weight categories. Their venous cord blood samples were collected to measure the levels of IGF-I, IGF-II, leptin, adiponectin, ghrelin, resistin, and visfatin.

Results IGF-I, visfatin, and leptin levels showed significant differences among the groups. Pairwise comparisons showed that adiponectin (p = 0.023), resistin (p = 0.025), and ghrelin (p = 0.005) levels were significantly lower in the SGA group than in the LGA group. Correlation analyses showed a strong association of IGF-1, IGF-II, and leptin levels with birth weight (r = 0.644, p < 0.001; r = 0.441, p < 0.001; and r = 0.404, p < 0.001, respectively).

Conclusion SGA newborns showed a significantly higher visfatin concentration and lower ghrelin, leptin, resistin, and adiponectin levels than the AGA and LGA newborns did.

Keywords

fetal growth - visfatin - ghrelin - leptin - resistin
 

  • References

  • 1 Gicquel C, Le Bouc Y. Hormonal regulation of fetal growth. Horm Res 2006; 65 (Suppl. 03) 28-33
    PubMedSuche in Google Scholar
  • 2 Dessì A, Ottonello G, Fanos V. Physiopathology of intrauterine growth retardation: from classic data to metabolomics. J Matern Fetal Neonatal Med 2012; 25 (Suppl. 05) 13-18
    CrossrefPubMedSuche in Google Scholar
  • 3 Meier U, Gressner AM. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem 2004; 50 (09) 1511-1525
    CrossrefPubMedSuche in Google Scholar
  • 4 Briana DD, Malamitsi-Puchner A. The role of adipocytokines in fetal growth. Ann N Y Acad Sci 2010; 1205: 82-87
    CrossrefPubMedSuche in Google Scholar
  • 5 Baker J, Liu JP, Robertson EJ, Efstratiadis A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 1993; 75 (01) 73-82
    CrossrefPubMedSuche in Google Scholar
  • 6 DeChiara TM, Efstratiadis A, Robertson EJ. A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature 1990; 345 (6270): 78-80
    CrossrefPubMedSuche in Google Scholar
  • 7 Powell-Braxton L, Hollingshead P, Warburton C. , et al. IGF-I is required for normal embryonic growth in mice. Genes Dev 1993; 7 (12B): 2609-2617
    CrossrefPubMedSuche in Google Scholar
  • 8 Ong K, Kratzsch J, Kiess W, Costello M, Scott C, Dunger D. ; The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. Size at birth and cord blood levels of insulin, insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-1 (IGFBP-1), IGFBP-3, and the soluble IGF-II/mannose-6-phosphate receptor in term human infants. J Clin Endocrinol Metab 2000; 85 (11) 4266-4269
    PubMedSuche in Google Scholar
  • 9 Luo ZC, Nuyt AM, Delvin E. , et al. Maternal and fetal IGF-I and IGF-II levels, fetal growth, and gestational diabetes. J Clin Endocrinol Metab 2012; 97 (05) 1720-1728
    CrossrefPubMedSuche in Google Scholar
  • 10 Ostlund E, Bang P, Hagenäs L, Fried G. Insulin-like growth factor I in fetal serum obtained by cordocentesis is correlated with intrauterine growth retardation. Hum Reprod 1997; 12 (04) 840-844
    CrossrefPubMedSuche in Google Scholar
  • 11 Lubchenco LO, Hansman C, Boyd E. Intrauterine growth in length and head circumference as estimated from live births at gestational ages from 26 to 42 weeks. Pediatrics 1966; 37 (03) 403-408
    CrossrefPubMedSuche in Google Scholar
  • 12 Chauhan SP, Rice MM, Grobman WA. , et al; MSCE, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network. Neonatal morbidity of small- and large-for-gestational-age neonates born at term in uncomplicated pregnancies. Obstet Gynecol 2017; 130 (03) 511-519
    CrossrefPubMedSuche in Google Scholar
  • 13 Landmann E, Reiss I, Misselwitz B, Gortner L. Ponderal index for discrimination between symmetric and asymmetric growth restriction: percentiles for neonates from 30 weeks to 43 weeks of gestation. J Matern Fetal Neonatal Med 2006; 19 (03) 157-160
    CrossrefPubMedSuche in Google Scholar
  • 14 de Jong M, Cranendonk A, van Weissenbruch MM. Components of the metabolic syndrome in early childhood in very-low-birth-weight infants and term small and appropriate for gestational age infants. Pediatr Res 2015; 78 (04) 457-461
    CrossrefPubMedSuche in Google Scholar
  • 15 Yeung EH, McLain AC, Anderson N. , et al. Newborn adipokines and birth outcomes. Paediatr Perinat Epidemiol 2015; 29 (04) 317-325
    CrossrefPubMedSuche in Google Scholar
  • 16 Olsen IE, Groveman SA, Lawson ML, Clark RH, Zemel BS. New intrauterine growth curves based on United States data. Pediatrics 2010; 125 (02) e214-e224
    CrossrefPubMedSuche in Google Scholar
  • 17 Malamitsi-Puchner A, Briana DD, Boutsikou M, Kouskouni E, Hassiakos D, Gourgiotis D. Perinatal circulating visfatin levels in intrauterine growth restriction. Pediatrics 2007; 119 (06) e1314-e1318
    CrossrefPubMedSuche in Google Scholar
  • 18 Meral C, Cekmez F, Pirgon O. , et al. The relationship between serum visfatin, adiponectin, and insulin sensitivity markers in neonates after birth. J Matern Fetal Neonatal Med 2011; 24 (01) 166-170
    CrossrefPubMedSuche in Google Scholar
  • 19 Briana DD, Boutsikou M, Gourgiotis D. , et al. Role of visfatin, insulin-like growth factor-I and insulin in fetal growth. J Perinat Med 2007; 35 (04) 326-329
    PubMedSuche in Google Scholar
  • 20 Tsai PJ, Yu CH, Hsu SP. , et al. Cord plasma concentrations of adiponectin and leptin in healthy term neonates: positive correlation with birthweight and neonatal adiposity. Clin Endocrinol (Oxf) 2004; 61 (01) 88-93
    CrossrefPubMedSuche in Google Scholar
  • 21 Cekmez F, Pirgon O, Tanju A, Ipcioglu OM. Cord plasma concentrations of visfatin, adiponectin and insulin in healthy term neonates: positive correlation with birthweight. Int J Biomed Sci 2009; 5 (03) 257-260
    PubMedSuche in Google Scholar
  • 22 Kyriakakou M, Malamitsi-Puchner A, Militsi H. , et al. Leptin and adiponectin concentrations in intrauterine growth restricted and appropriate for gestational age fetuses, neonates, and their mothers. Eur J Endocrinol 2008; 158 (03) 343-348
    CrossrefPubMedSuche in Google Scholar
  • 23 Berg AH, Combs TP, Scherer PE. ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab 2002; 13 (02) 84-89
    CrossrefPubMedSuche in Google Scholar
  • 24 Evagelidou EN, Giapros VI, Challa AS, Kiortsis DN, Tsatsoulis AA, Andronikou SK. Serum adiponectin levels, insulin resistance, and lipid profile in children born small for gestational age are affected by the severity of growth retardation at birth. Eur J Endocrinol 2007; 156 (02) 271-277
    CrossrefPubMedSuche in Google Scholar
  • 25 Martínez-Cordero C, Amador-Licona N, Guízar-Mendoza JM, Hernández-Méndez J, Ruelas-Orozco G. Body fat at birth and cord blood levels of insulin, adiponectin, leptin, and insulin-like growth factor-I in small-for-gestational-age infants. Arch Med Res 2006; 37 (04) 490-494
    CrossrefPubMedSuche in Google Scholar
  • 26 Karakosta P, Georgiou V, Fthenou E. , et al. Maternal weight status, cord blood leptin and fetal growth: a prospective mother-child cohort study (Rhea study). Paediatr Perinat Epidemiol 2013; 27 (05) 461-471
    CrossrefPubMedSuche in Google Scholar
  • 27 Mantzoros CS, Rifas-Shiman SL, Williams CJ, Fargnoli JL, Kelesidis T, Gillman MW. Cord blood leptin and adiponectin as predictors of adiposity in children at 3 years of age: a prospective cohort study. Pediatrics 2009; 123 (02) 682-689
    CrossrefPubMedSuche in Google Scholar
  • 28 Lepercq J, Taupin P, Dubois-Laforgue D. , et al. Heterogeneity of fetal growth in type 1 diabetic pregnancy. Diabetes Metab 2001; 27 (03) 339-344
    PubMedSuche in Google Scholar
  • 29 Forhead AJ, Fowden AL. The hungry fetus? Role of leptin as a nutritional signal before birth. J Physiol 2009; 587 (Pt 6): 1145-1152
    CrossrefPubMedSuche in Google Scholar
  • 30 Harigaya A, Nagashima K, Nako Y, Morikawa A. Relationship between concentration of serum leptin and fetal growth. J Clin Endocrinol Metab 1997; 82 (10) 3281-3284
    CrossrefPubMedSuche in Google Scholar
  • 31 Harrington TA, Thomas EL, Frost G, Modi N, Bell JD. Distribution of adipose tissue in the newborn. Pediatr Res 2004; 55 (03) 437-441
    CrossrefPubMedSuche in Google Scholar
  • 32 Steppan CM, Bailey ST, Bhat S. , et al. The hormone resistin links obesity to diabetes. Nature 2001; 409 (6818): 307-312
    CrossrefPubMedSuche in Google Scholar
  • 33 Farid SD, Najati N, Gharebaghi MM, Haghjo AG, Ghojazadeh M. Resistin in cord blood of small for gestation age and appropriate for gestation age term neonates. Iran J Pediatr 2013; 23 (06) 659-663
    PubMedSuche in Google Scholar
  • 34 Cho GJ, Yoo SW, Hong SC. , et al. Correlations between umbilical and maternal serum resistin levels and neonatal birth weight. Acta Obstet Gynecol Scand 2006; 85 (09) 1051-1056
    CrossrefPubMedSuche in Google Scholar
  • 35 Chanoine JP. Ghrelin in growth and development. Horm Res 2005; 63 (03) 129-138
    CrossrefPubMedSuche in Google Scholar
  • 36 Onal EE, Cinaz P, Atalay Y. , et al. Umbilical cord ghrelin concentrations in small- and appropriate-for-gestational age newborn infants: relationship to anthropometric markers. J Endocrinol 2004; 180 (02) 267-271
    CrossrefPubMedSuche in Google Scholar
  • 37 Chanoine JP, Yeung LP, Wong AC, Birmingham CL. Immunoreactive ghrelin in human cord blood: relation to anthropometry, leptin, and growth hormone. J Pediatr Gastroenterol Nutr 2002; 35 (03) 282-286
    CrossrefPubMedSuche in Google Scholar
  • 38 Otto B, Tschöp M, Heldwein W, Pfeiffer AF, Diederich S. Endogenous and exogenous glucocorticoids decrease plasma ghrelin in humans. Eur J Endocrinol 2004; 151 (01) 113-117
    PubMedSuche in Google Scholar
  • 39 Espelund U, Hansen TK, Højlund K. , et al. Fasting unmasks a strong inverse association between ghrelin and cortisol in serum: studies in obese and normal-weight subjects. J Clin Endocrinol Metab 2005; 90 (02) 741-746
    CrossrefPubMedSuche in Google Scholar
  • 40 Agrogiannis GD, Sifakis S, Patsouris ES, Konstantinidou AE. Insulin-like growth factors in embryonic and fetal growth and skeletal development (Review). Mol Med Rep 2014; 10 (02) 579-584
    CrossrefPubMedSuche in Google Scholar
  • 41 Bhaumick B, Bala RM. Differential effects of insulin-like growth factors I and II on growth, differentiation and glucoregulation in differentiating chondrocyte cells in culture. Acta Endocrinol (Copenh) 1991; 125 (02) 201-211
    PubMedSuche in Google Scholar
  • 42 Liu J-P, Baker J, Perkins AS, Robertson EJ, Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 1993; 75 (01) 59-72
    PubMedSuche in Google Scholar
  • 43 Gluckman PD, Johnson-Barrett JJ, Butler JH, Edgar BW, Gunn TR. Studies of insulin-like growth factor -I and -II by specific radioligand assays in umbilical cord blood. Clin Endocrinol (Oxf) 1983; 19 (03) 405-413
    CrossrefPubMedSuche in Google Scholar
  • 44 Lassarre C, Hardouin S, Daffos F, Forestier F, Frankenne F, Binoux M. Serum insulin-like growth factors and insulin-like growth factor binding proteins in the human fetus. Relationships with growth in normal subjects and in subjects with intrauterine growth retardation. Pediatr Res 1991; 29 (03) 219-225
    CrossrefPubMedSuche in Google Scholar
  • 45 Christou H, Connors JM, Ziotopoulou M. , et al. Cord blood leptin and insulin-like growth factor levels are independent predictors of fetal growth. J Clin Endocrinol Metab 2001; 86 (02) 935-938
    CrossrefPubMedSuche in Google Scholar
  • 46 Randhawa R, Cohen P. The role of the insulin-like growth factor system in prenatal growth. Mol Genet Metab 2005; 86 (1-2): 84-90
    CrossrefPubMedSuche in Google Scholar
  • 47 Chiesa C, Osborn JF, Haass C. , et al. Ghrelin, leptin, IGF-1, IGFBP-3, and insulin concentrations at birth: is there a relationship with fetal growth and neonatal anthropometry?. Clin Chem 2008; 54 (03) 550-558
    CrossrefPubMedSuche in Google Scholar
  • 48 Bennet L, Oliver MH, Gunn AJ, Hennies M, Breier BH. Differential changes in insulin-like growth factors and their binding proteins following asphyxia in the preterm fetal sheep. J Physiol 2001; 531 (Pt 3): 835-841
    CrossrefPubMedSuche in Google Scholar
  • 49 Kitamura S, Yokota I, Hosoda H. , et al. Ghrelin concentration in cord and neonatal blood: relation to fetal growth and energy balance. J Clin Endocrinol Metab 2003; 88 (11) 5473-5477
    CrossrefPubMedSuche in Google Scholar
  • 50 Soriano-Guillén L, Barrios V, Chowen JA. , et al. Ghrelin levels from fetal life through early adulthood: relationship with endocrine and metabolic and anthropometric measures. J Pediatr 2004; 144 (01) 30-35
    CrossrefPubMedSuche in Google Scholar