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Semin Respir Crit Care Med 2018; 39(05): 609-624
DOI: 10.1055/s-0038-1675333
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Perioperative Considerations in Liver Transplantation

Igor Barjaktarevic
1   Division of Pulmonary and Critical Care Medicine, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, California
,
Roxana Cortes Lopez
1   Division of Pulmonary and Critical Care Medicine, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, California
,
Randolph Steadman
2   Department of Anesthesia, UCLA David Geffen School of Medicine, Los Angeles, California
,
Christopher Wray
2   Department of Anesthesia, UCLA David Geffen School of Medicine, Los Angeles, California
,
Nida Qadir
1   Division of Pulmonary and Critical Care Medicine, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, California
,
Steven Y. Chang
1   Division of Pulmonary and Critical Care Medicine, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, California
,
Tisha Wang
1   Division of Pulmonary and Critical Care Medicine, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, California
› Author Affiliations
Further Information

Publication History

Publication Date:
28 November 2018 (online)

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Abstract

Liver transplantation (LT) has the potential to cure patients with acute and chronic liver failure as well as a number of hepatic and biliary malignancies. Over time, due to the increasing demand for organs as well as improvements in the survival of LT recipients, patients awaiting LT have become sicker, and often undergo the procedure while critically ill. This trend has made the process of preoperative assessment and planning, intraoperative management, and postoperative management even more crucial to the success of LT programs. Multidisciplinary and specialized teams are essential and include anesthesiologists, surgeons, and intensivists. This article focuses on the preoperative evaluation, intraoperative care, and postoperative management of the liver transplant patient. Management relevant to the critically ill patient is discussed, with a focus on the management of postoperative cardiopulmonary conditions including the care of special populations such as those with hepatopulmonary syndrome and portopulmonary hypertension.

Keywords

liver transplantation - anesthesia - end-stage liver disease - postoperative critical care - hepatopulmonary syndrome - portopulmonary hypertension
 

  • References

  • 1 Linecker M, Krones T, Berg T. , et al. Potentially inappropriate liver transplantation in the era of the “sickest first” policy - a search for the upper limits. J Hepatol 2018; 68 (04) 798-813
    CrossrefPubMedGoogle Scholar
  • 2 Carmona M, Álvarez M, Marco J, Mahíllo B, Domínguez-Gil B, Núñez JR, Matesanz R. Global organ transplant activities in 2015. Data from the Global Observatory on Donation and Transplantation (GODT). Transplantation 2017; 101: S29
    PubMedGoogle Scholar
  • 3 Shukla A, Vadeyar H, Rela M, Shah S. Liver transplantation: East versus West. J Clin Exp Hepatol 2013; Sep; 3 (03) 243-253 . doi: 10.1016/j.jceh.2013.08.004
    CrossrefPubMedGoogle Scholar
  • 4 Elzouki AN, Suliman S, Alhasan R, Abdullah A, Othman M, Badi A. Predicting mortality of patients with cirrhosis admitted to medical intensive care unit: an experience of a single tertiary center. Arab J Gastroenterol 2016; 17 (04) 159-163
    CrossrefPubMedGoogle Scholar
  • 5 Kamath PS, Wiesner RH, Malinchoc M. , et al. A model to predict survival in patients with end-stage liver disease. Hepatology 2001; 33 (02) 464-470
    CrossrefPubMedGoogle Scholar
  • 6 Kim WR, Lake JR, Smith JM. , et al. OPTN/SRTR 2016 Annual Data Report: liver. Am J Transplant 2018; 18 (Suppl. 01) 172-253
    CrossrefPubMedGoogle Scholar
  • 7 Goel A, Kim WR, Pyke J. , et al. Liver simulated allocation modeling: were the predictions accurate for share 35?. Transplantation 2018; 102 (05) 769-774
    CrossrefPubMedGoogle Scholar
  • 8 Weismüller TJ, Fikatas P, Schmidt J. , et al. Multicentric evaluation of model for end-stage liver disease-based allocation and survival after liver transplantation in Germany--limitations of the ‘sickest first’-concept. Transpl Int 2011; 24 (01) 91-99
    CrossrefPubMedGoogle Scholar
  • 9 Bittermann T, Makar G, Goldberg DS. Early post-transplant survival: Interaction of MELD score and hospitalization status. J Hepatol 2015; 63 (03) 601-608
    CrossrefPubMedGoogle Scholar
  • 10 Nadim MK, Durand F, Kellum JA. , et al. Management of the critically ill patient with cirrhosis: a multidisciplinary perspective. J Hepatol 2016; 64 (03) 717-735
    CrossrefPubMedGoogle Scholar
  • 11 Sibulesky L, Heckman MG, Taner CB. , et al. Outcomes following liver transplantation in intensive care unit patients. World J Hepatol 2013; 5 (01) 26-32
    CrossrefPubMedGoogle Scholar
  • 12 Aggarwal A, Ong JP, Younossi ZM, Nelson DR, Hoffman-Hogg L, Arroliga AC. Predictors of mortality and resource utilization in cirrhotic patients admitted to the medical ICU. Chest 2001; 119 (05) 1489-1497
    CrossrefPubMedGoogle Scholar
  • 13 Gonwa TA, Mai ML, Melton LB. , et al. Renal replacement therapy and orthotopic liver transplantation: the role of continuous veno-venous hemodialysis. Transplantation 2001; 71 (10) 1424-1428
    CrossrefPubMedGoogle Scholar
  • 14 Li C, Wen TF, Yan LN. , et al. Predictors of patient survival following living donor liver transplantation. Hepatobiliary Pancreat Dis Int 2011; 10 (03) 248-253
    CrossrefPubMedGoogle Scholar
  • 15 Markmann JF, Markmann JW, Markmann DA. , et al. Preoperative factors associated with outcome and their impact on resource use in 1148 consecutive primary liver transplants. Transplantation 2001; 72 (06) 1113-1122
    CrossrefPubMedGoogle Scholar
  • 16 Desai NM, Mange KC, Crawford MD. , et al. Predicting outcome after liver transplantation: utility of the model for end-stage liver disease and a newly derived discrimination function. Transplantation 2004; 77 (01) 99-106
    CrossrefPubMedGoogle Scholar
  • 17 Knaak J, McVey M, Bazerbachi F. , et al. Liver transplantation in patients with end-stage liver disease requiring intensive care unit admission and intubation. Liver Transpl 2015; 21 (06) 761-767
    CrossrefPubMedGoogle Scholar
  • 18 Kress JP, Rubin A, Pohlman AS, Hall JB. Outcomes of critically ill patients denied consideration for liver transplantation. Am J Respir Crit Care Med 2000; 162 (2, Pt 1): 418-423
    CrossrefPubMedGoogle Scholar
  • 19 Therapondos G, Flapan AD, Plevris JN, Hayes PC. Cardiac morbidity and mortality related to orthotopic liver transplantation. Liver Transpl 2004; 10 (12) 1441-1453
    CrossrefPubMedGoogle Scholar
  • 20 Gelson W, Hoare M, Dawwas MF, Vowler S, Gibbs P, Alexander G. The pattern of late mortality in liver transplant recipients in the United Kingdom. Transplantation 2011; 91 (11) 1240-1244
    CrossrefPubMedGoogle Scholar
  • 21 Lentine KL, Costa SP, Weir MR. , et al; American Heart Association Council on the Kidney in Cardiovascular Disease and Council on Peripheral Vascular Disease. Cardiac disease evaluation and management among kidney and liver transplantation candidates: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol 2012; 60 (05) 434-480
    CrossrefPubMedGoogle Scholar
  • 22 Kadayifci A, Tan V, Ursell PC, Merriman RB, Bass NM. Clinical and pathologic risk factors for atherosclerosis in cirrhosis: a comparison between NASH-related cirrhosis and cirrhosis due to other aetiologies. J Hepatol 2008; 49 (04) 595-599
    CrossrefPubMedGoogle Scholar
  • 23 Diedrich DA, Findlay JY, Harrison BA, Rosen CB. Influence of coronary artery disease on outcomes after liver transplantation. Transplant Proc 2008; 40 (10) 3554-3557
    CrossrefPubMedGoogle Scholar
  • 24 Plotkin JS, Scott VL, Pinna A, Dobsch BP, De Wolf AM, Kang Y. Morbidity and mortality in patients with coronary artery disease undergoing orthotopic liver transplantation. Liver Transpl Surg 1996; 2 (06) 426-430
    CrossrefPubMedGoogle Scholar
  • 25 Maddur H, Bourdillon PD, Liangpunsakul S. , et al. Role of cardiac catheterization and percutaneous coronary intervention in the preoperative assessment and management of patients before orthotopic liver transplantation. Liver Transpl 2014; 20 (06) 664-672
    CrossrefPubMedGoogle Scholar
  • 26 Wray C, Scovotti JC, Tobis J. , et al. Liver transplantation outcome in patients with angiographically proven coronary artery disease: a multi-institutional study. Am J Transplant 2013; 13 (01) 184-191
    CrossrefPubMedGoogle Scholar
  • 27 Satapathy SK, Vanatta JM, Helmick RA. , et al. Outcome of liver transplant recipients with revascularized coronary artery disease: a comparative analysis with and without cardiovascular risk factors. Transplantation 2017; 101 (04) 793-803
    CrossrefPubMedGoogle Scholar
  • 28 Martin P, DiMartini A, Feng S, Brown Jr R, Fallon M. Evaluation for liver transplantation in adults: 2013 practice guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation. Hepatology 2014; 59 (03) 1144-1165
    CrossrefPubMedGoogle Scholar
  • 29 Fleisher LA, Fleischmann KE, Auerbach AD. , et al. 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2014; 130 (24) 2215-2245
    CrossrefPubMedGoogle Scholar
  • 30 Sharma M, Yong C, Majure D. , et al. Safety of cardiac catheterization in patients with end-stage liver disease awaiting liver transplantation. Am J Cardiol 2009; 103 (05) 742-746
    CrossrefPubMedGoogle Scholar
  • 31 Pillarisetti J, Patel P, Duthuluru S. , et al. Cardiac catheterization in patients with end-stage liver disease: safety and outcomes. Catheter Cardiovasc Interv 2011; 77 (01) 45-48
    CrossrefPubMedGoogle Scholar
  • 32 Shaheen AA, Kaplan GG, Hubbard JN, Myers RP. Morbidity and mortality following coronary artery bypass graft surgery in patients with cirrhosis: a population-based study. Liver Int 2009; 29 (08) 1141-1151
    CrossrefPubMedGoogle Scholar
  • 33 Møller S, Henriksen JH. Cirrhotic cardiomyopathy. J Hepatol 2010; 53 (01) 179-190
    CrossrefPubMedGoogle Scholar
  • 34 Kertai MD, Bountioukos M, Boersma E. , et al. Aortic stenosis: an underestimated risk factor for perioperative complications in patients undergoing noncardiac surgery. Am J Med 2004; 116 (01) 8-13
    CrossrefPubMedGoogle Scholar
  • 35 Silvestre OM, Bacal F, Ramos DS. , et al. Transcatheter aortic valve implantation as rescue therapy for liver transplant candidates with aortic valve stenosis. Liver Transpl 2014; 20 (10) 1277-1279
    CrossrefPubMedGoogle Scholar
  • 36 Wilkey BJ, Hanson R, Reece TB. , et al. Transfemoral transcatheter aortic valve replacement for mixed aortic valve disease in Child's Class C liver disease prior to orthotopic liver transplantation: a case report. Semin Cardiothorac Vasc Anesth 2016; 20 (02) 158-162
    CrossrefPubMedGoogle Scholar
  • 37 Bargehr J, Trejo-Gutierrez JF, Patel T. , et al. Preexisting atrial fibrillation and cardiac complications after liver transplantation. Liver Transpl 2015; 21 (03) 314-320
    CrossrefPubMedGoogle Scholar
  • 38 Vannucci A, Rathor R, Vachharajani N, Chapman W, Kangrga I. Atrial fibrillation in patients undergoing liver transplantation-a single-center experience. Transplant Proc 2014; 46 (05) 1432-1437
    CrossrefPubMedGoogle Scholar
  • 39 January CT, Wann LS, Alpert JS. , et al; ACC/AHA Task Force Members. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. Circulation 2014; 130 (23) e199-e267
    PubMedGoogle Scholar
  • 40 Son SK, Oh SH, Kim KM. , et al. Successful liver transplantation following veno-arterial extracorporeal membrane oxygenation in a child with fulminant Wilson disease and severe pulmonary hemorrhage: a case report. Pediatr Transplant 2012; 16 (07) E281-E285
    CrossrefPubMedGoogle Scholar
  • 41 Monsel A, Mal H, Brisson H. , et al. Extracorporeal membrane oxygenation as a bridge to liver transplantation for acute respiratory distress syndrome-induced life-threatening hypoxaemia aggravated by hepatopulmonary syndrome. Crit Care 2011; 15 (05) R234
    CrossrefPubMedGoogle Scholar
  • 42 Kawut SM, Krowka MJ, Trotter JF. , et al; Pulmonary Vascular Complications of Liver Disease Study Group. Clinical risk factors for portopulmonary hypertension. Hepatology 2008; 48 (01) 196-203
    CrossrefPubMedGoogle Scholar
  • 43 Huang B, Shi Y, Liu J. , et al. The early outcomes of candidates with portopulmonary hypertension after liver transplantation. BMC Gastroenterol 2018; 18 (01) 79
    CrossrefPubMedGoogle Scholar
  • 44 Krowka MJ, Fallon MB, Kawut SM. , et al. International Liver Transplant Society Practice Guidelines: diagnosis and management of hepatopulmonary syndrome and portopulmonary hypertension. Transplantation 2016; 100 (07) 1440-1452
    CrossrefPubMedGoogle Scholar
  • 45 Krowka MJ, Mandell MS, Ramsay MA. , et al. Hepatopulmonary syndrome and portopulmonary hypertension: a report of the multicenter liver transplant database. Liver Transpl 2004; 10 (02) 174-182
    CrossrefPubMedGoogle Scholar
  • 46 Zopey R, Susanto I, Barjaktarevic I, Wang T. Transition from hepatopulmonary syndrome to portopulmonary hypertension: a case series of 3 patients. Case Rep Pulmonol 2013; 2013: 561870
    PubMedGoogle Scholar
  • 47 Shahangian S, Shino MY, Barjaktarevic I. , et al. Interstitial lung disease in patients with hepatopulmonary syndrome: a case series and new observations. Lung 2014; 192 (03) 421-427
    CrossrefPubMedGoogle Scholar
  • 48 Goldberg DS, Krok K, Batra S, Trotter JF, Kawut SM, Fallon MB. Impact of the hepatopulmonary syndrome MELD exception policy on outcomes of patients after liver transplantation: an analysis of the UNOS database. Gastroenterology 2014; 146 (05) 1256-65.e1
    CrossrefPubMedGoogle Scholar
  • 49 Schenk P, Fuhrmann V, Madl C. , et al. Hepatopulmonary syndrome: prevalence and predictive value of various cut offs for arterial oxygenation and their clinical consequences. Gut 2002; 51 (06) 853-859
    CrossrefPubMedGoogle Scholar
  • 50 Grilo-Bensusan I, Pascasio-Acevedo JM. Hepatopulmonary syndrome: what we know and what we would like to know. World J Gastroenterol 2016; 22 (25) 5728-5741
    CrossrefPubMedGoogle Scholar
  • 51 Gupta S, Fenves AZ, Hootkins R. The role of RRT in hyperammonemic patients. Clin J Am Soc Nephrol 2016; 11 (10) 1872-1878
    CrossrefPubMedGoogle Scholar
  • 52 Hartmann M, Szalai C, Saner FH. Hemostasis in liver transplantation: pathophysiology, monitoring, and treatment. World J Gastroenterol 2016; 22 (04) 1541-1550
    CrossrefPubMedGoogle Scholar
  • 53 Stine JG, Northup PG. Coagulopathy before and after liver transplantation: from the hepatic to the systemic circulatory systems. Clin Liver Dis 2017; 21 (02) 253-274
    CrossrefPubMedGoogle Scholar
  • 54 Lai JC. Defining the threshold for too sick for transplant. Curr Opin Organ Transplant 2016; 21 (02) 127-132
    CrossrefPubMedGoogle Scholar
  • 55 Petrowsky H, Rana A, Kaldas FM. , et al. Liver transplantation in highest acuity recipients: identifying factors to avoid futility. Ann Surg 2014; 259 (06) 1186-1194
    CrossrefPubMedGoogle Scholar
  • 56 Kim BS, Lee SG, Hwang S. , et al. Influence of pretransplantation bacterial and fungal culture positivity on outcome after living donor liver transplantation. Transplant Proc 2009; 41 (01) 250-252
    CrossrefPubMedGoogle Scholar
  • 57 Sun HY, Cacciarelli TV, Singh N. Impact of pretransplant infections on clinical outcomes of liver transplant recipients. Liver Transpl 2010; 16 (02) 222-228
    CrossrefPubMedGoogle Scholar
  • 58 Hofer I, Spivack J, Yaport M. , et al. Association between anesthesiologist experience and mortality after orthotopic liver transplantation. Liver Transpl 2015; 21 (01) 89-95
    CrossrefPubMedGoogle Scholar
  • 59 Rudnick MR, Marchi LD, Plotkin JS. Hemodynamic monitoring during liver transplantation: a state of the art review. World J Hepatol 2015; 7 (10) 1302-1311
    CrossrefPubMedGoogle Scholar
  • 60 Soong W, Sherwani SS, Ault ML, Baudo AM, Herborn JC, De Wolf AM. United States practice patterns in the use of transesophageal echocardiography during adult liver transplantation. J Cardiothorac Vasc Anesth 2014; 28 (03) 635-639
    CrossrefPubMedGoogle Scholar
  • 61 Burger-Klepp U, Karatosic R, Thum M. , et al. Transesophageal echocardiography during orthotopic liver transplantation in patients with esophagoastric varices. Transplantation 2012; 94 (02) 192-196
    PubMedGoogle Scholar
  • 62 Biancofiore G, Critchley LAH, Lee A. , et al. Evaluation of a new software version of the FloTrac/Vigileo (version 3.02) and a comparison with previous data in cirrhotic patients undergoing liver transplant surgery. Anesth Analg 2011; 113 (03) 515-522
    PubMedGoogle Scholar
  • 63 Tsai YF, Su BC, Lin CC, Liu FC, Lee WC, Yu HP. Cardiac output derived from arterial pressure waveform analysis: validation of the third-generation software in patients undergoing orthotopic liver transplantation. Transplant Proc 2012; 44 (02) 433-437
    CrossrefPubMedGoogle Scholar
  • 64 Bezinover D, Dirkmann D, Findlay J. , et al. Perioperative coagulation management in liver transplant recipients. Transplantation 2018; 102 (04) 578-592
    CrossrefPubMedGoogle Scholar
  • 65 Görlinger K, Dirkmann D, Solomon C, Hanke AA. Fast interpretation of thromboelastometry in non-cardiac surgery: reliability in patients with hypo-, normo-, and hypercoagulability. Br J Anaesth 2013; 110 (02) 222-230
    CrossrefPubMedGoogle Scholar
  • 66 Morrison GA, Chalmers RTA, Solomon C, Nimmo AF. Fibrinogen concentrate therapy guided by thromboelastometry as an alternative to fresh frozen plasma in major vascular surgery. J Cardiothorac Vasc Anesth 2012; 26 (04) 654-659
    CrossrefPubMedGoogle Scholar
  • 67 Chow JH, Lee K, Abuelkasem E, Udekwu OR, Tanaka KA. Coagulation management during liver transplantation: use of fibrinogen concentrate, recombinant activated factor VII, prothrombin complex concentrate, and antifibrinolytics. Semin Cardiothorac Vasc Anesth 2018; 22 (02) 164-173
    CrossrefPubMedGoogle Scholar
  • 68 Sørensen B, Spahn DR, Innerhofer P, Spannagl M, Rossaint R. Clinical review: prothrombin complex concentrates--evaluation of safety and thrombogenicity. Crit Care 2011; 15 (01) 201
    CrossrefPubMedGoogle Scholar
  • 69 Dentali F, Marchesi C, Giorgi Pierfranceschi M. , et al. Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists. A meta-analysis. Thromb Haemost 2011; 106 (03) 429-438
    Article in Thieme ConnectPubMedGoogle Scholar
  • 70 Planinsic RM, van der Meer J, Testa G. , et al. Safety and efficacy of a single bolus administration of recombinant factor VIIa in liver transplantation due to chronic liver disease. Liver Transpl 2005; 11 (08) 895-900
    CrossrefPubMedGoogle Scholar
  • 71 Lodge JPA, Jonas S, Jones RM. , et al; rFVIIa OLT Study Group. Efficacy and safety of repeated perioperative doses of recombinant factor VIIa in liver transplantation. Liver Transpl 2005; 11 (08) 973-979
    CrossrefPubMedGoogle Scholar
  • 72 Levi M, Levy JH, Andersen HF, Truloff D. Safety of recombinant activated factor VII in randomized clinical trials. N Engl J Med 2010; 363 (19) 1791-1800
    CrossrefPubMedGoogle Scholar
  • 73 Rossaint R, Bouillon B, Cerny V. , et al. The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Critical Care 2016; 20 (01) 100
    CrossrefPubMedGoogle Scholar
  • 74 Pereboom ITA, de Boer MT, Haagsma EB, Hendriks HGD, Lisman T, Porte RJ. Platelet transfusion during liver transplantation is associated with increased postoperative mortality due to acute lung injury. Anesth Analg 2009; 108 (04) 1083-1091
    CrossrefPubMedGoogle Scholar
  • 75 Chin JL, Hisamuddin SH, O'Sullivan A, Chan G, McCormick PA. Thrombocytopenia, platelet transfusion, and outcome following liver transplantation. Clin Appl Thromb Hemost 2016; 22 (04) 351-360
    CrossrefPubMedGoogle Scholar
  • 76 Kang Y. Transfusion based on clinical coagulation monitoring does reduce hemorrhage during liver transplantation. Liver Transpl Surg 1997; 3 (06) 655-659
    CrossrefPubMedGoogle Scholar
  • 77 Deppe A-C, Weber C, Zimmermann J. , et al. Point-of-care thromboelastography/thromboelastometry-based coagulation management in cardiac surgery: a meta-analysis of 8332 patients. J Surg Res 2016; 203 (02) 424-433
    CrossrefPubMedGoogle Scholar
  • 78 Roullet S, Freyburger G, Cruc M. , et al. Management of bleeding and transfusion during liver transplantation before and after the introduction of a rotational thromboelastometry-based algorithm. Liver Transpl 2015; 21 (02) 169-179
    CrossrefPubMedGoogle Scholar
  • 79 Kirchner C, Dirkmann D, Treckmann JW. , et al. Coagulation management with factor concentrates in liver transplantation: a single-center experience. Transfusion 2014; 54 (10, Pt 2): 2760-2768
    CrossrefPubMedGoogle Scholar
  • 80 Haagsma EB, Gips CH, Wesenhagen H, Van Imhoff GW, Krom RA. Liver disease and its effect on haemostasis during liver transplantation. Liver 1985; 5 (03) 123-128
    PubMedGoogle Scholar
  • 81 Bechstein WO, Neuhaus P. A surgeon's perspective on the management of coagulation disorders before liver transplantation. Liver Transpl Surg 1997; 3 (06) 653-655
    CrossrefPubMedGoogle Scholar
  • 82 Massicotte L, Denault AY, Beaulieu D. , et al. Transfusion rate for 500 consecutive liver transplantations: experience of one liver transplantation center. Transplantation 2012; 93 (12) 1276-1281
    CrossrefPubMedGoogle Scholar
  • 83 Fonouni H, Mehrabi A, Soleimani M, Müller SA, Büchler MW, Schmidt J. The need for venovenous bypass in liver transplantation. HPB 2008; 10 (03) 196-203
    CrossrefPubMedGoogle Scholar
  • 84 Wszolek ZK, McComb RD, Pfeiffer RF. , et al. Pontine and extrapontine myelinolysis following liver transplantation. Relationship to serum sodium. Transplantation 1989; 48 (06) 1006-1012
    CrossrefPubMedGoogle Scholar
  • 85 Lee EM, Kang JK, Yun S-C. , et al. Risk factors for central pontine and extrapontine myelinolysis following orthotopic liver transplantation. Eur Neurol 2009; 62 (06) 362-368
    CrossrefPubMedGoogle Scholar
  • 86 Scott VL, De Wolf AM, Kang Y. , et al. Ionized hypomagnesemia in patients undergoing orthotopic liver transplantation: a complication of citrate intoxication. Liver Transpl Surg 1996; 2 (05) 343-347
    CrossrefPubMedGoogle Scholar
  • 87 Park C, Hsu C, Neelakanta G. , et al. Severe intraoperative hyperglycemia is independently associated with surgical site infection after liver transplantation. Transplantation 2009; 87 (07) 1031-1036
    CrossrefPubMedGoogle Scholar
  • 88 Holmes CL, Walley KR. Bad medicine: low-dose dopamine in the ICU. Chest 2003; 123 (04) 1266-1275
    CrossrefPubMedGoogle Scholar
  • 89 Bellomo R, Chapman M, Finfer S, Hickling K, Myburgh J. ; Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Lancet 2000; 356 (9248): 2139-2143
    CrossrefPubMedGoogle Scholar
  • 90 Rossi G, Langer M, Maggi U. , et al. Veno-venous bypass versus no bypass in orthotopic liver transplantation: hemodynamic, metabolic, and renal data. Transplant Proc 1998; 30 (05) 1871-1873
    CrossrefPubMedGoogle Scholar
  • 91 Prager MC, Gregory GA, Ascher NL, Roberts JP. Massive venous air embolism during orthotopic liver transplantation. Anesthesiology 1990; 72 (01) 198-200
    CrossrefPubMedGoogle Scholar
  • 92 Gurusamy KS, Koti R, Pamecha V, Davidson BR. Veno-venous bypass versus none for liver transplantation. Cochrane Database Syst Rev 2011; (03) CD007712
    PubMedGoogle Scholar
  • 93 Chui AK, Shi L, Tanaka K. , et al. Postreperfusion syndrome in orthotopic liver transplantation. Transplant Proc 2000; 32 (07) 2116-2117
    CrossrefPubMedGoogle Scholar
  • 94 Xia VW, Ghobrial RM, Du B. , et al. Predictors of hyperkalemia in the prereperfusion, early postreperfusion, and late postreperfusion periods during adult liver transplantation. Anesth Analg 2007; 105 (03) 780-785
    CrossrefPubMedGoogle Scholar
  • 95 Warnaar N, Molenaar IQ, Colquhoun SD. , et al. Intraoperative pulmonary embolism and intracardiac thrombosis complicating liver transplantation: a systematic review. J Thromb Haemost 2008; 6 (02) 297-302
    CrossrefPubMedGoogle Scholar
  • 96 Steadman RH. Anesthesia for liver transplant surgery. Anesthesiol Clin North America 2004; 22 (04) 687-711
    CrossrefPubMedGoogle Scholar
  • 97 Mangus RS, Kinsella SB, Fridell JA. , et al. Aminocaproic acid (Amicar) as an alternative to aprotinin (Trasylol) in liver transplantation. Transplant Proc 2014; 46 (05) 1393-1399
    CrossrefPubMedGoogle Scholar
  • 98 Kong HY, Wen XH, Huang SQ, Zhu SM. Epsilon-aminocaproic acid improves postrecirculation hemodynamics by reducing intraliver activated protein C consumption in orthotopic liver transplantation. World J Surg 2014; 38 (01) 177-185
    CrossrefPubMedGoogle Scholar
  • 99 Badenoch A, Sharma A, Gower S. , et al. The effectiveness and safety of tranexamic acid in orthotopic liver transplantation clinical practice: a propensity score matched cohort study. Transplantation 2017; 101 (07) 1658-1665
    CrossrefPubMedGoogle Scholar
  • 100 DiNorcia J, Lee MK, Harlander-Locke MP. , et al. Damage control as a strategy to manage postreperfusion hemodynamic instability and coagulopathy in liver transplant. JAMA Surg 2015; 150 (11) 1066-1072
    CrossrefPubMedGoogle Scholar
  • 101 Feltracco P, Barbieri S, Galligioni H, Michieletto E, Carollo C, Ori C. Intensive care management of liver transplanted patients. World J Hepatol 2011; 3 (03) 61-71
    CrossrefPubMedGoogle Scholar
  • 102 Levy MF, Greene L, Ramsay MA. , et al. Readmission to the intensive care unit after liver transplantation. Crit Care Med 2001; 29 (01) 18-24
    CrossrefPubMedGoogle Scholar
  • 103 Wray CL. Liver transplantation in patients with cardiac disease. Semin Cardiothorac Vasc Anesth 2018; 22 (02) 111-121
    CrossrefPubMedGoogle Scholar
  • 104 Dec GW, Kondo N, Farrell ML, Dienstag J, Cosimi AB, Semigran MJ. Cardiovascular complications following liver transplantation. Clin Transplant 1995; 9 (06) 463-471
    PubMedGoogle Scholar
  • 105 Ponnudurai RN, Koneru B, Akhtar SA. , et al. Vasopressor administration during liver transplant surgery and its effect on endotracheal reintubation rate in the postoperative period: a prospective, randomized, double-blind, placebo-controlled trial. Clin Ther 2005; 27 (02) 192-198
    CrossrefPubMedGoogle Scholar
  • 106 Tandon M, Karna ST, Pandey CK, Chaturvedi R. Diagnostic and therapeutic challenge of heart failure after liver transplant: case series. World J Hepatol 2017; 9 (33) 1253-1260
    CrossrefPubMedGoogle Scholar
  • 107 Eimer MJ, Wright JM, Wang EC. , et al. Frequency and significance of acute heart failure following liver transplantation. Am J Cardiol 2008; 101 (02) 242-244
    CrossrefPubMedGoogle Scholar
  • 108 Al-Hamoudi WK, Alqahtani S, Tandon P, Ma M, Lee SS. Hemodynamics in the immediate post-transplantation period in alcoholic and viral cirrhosis. World J Gastroenterol 2010; 16 (05) 608-612
    CrossrefPubMedGoogle Scholar
  • 109 Gopal PB, Kapoor D, Raya R, Subrahmanyam M, Juneja D, Sukanya B. Critical care issues in adult liver transplantation. Indian J Crit Care Med 2009; 13 (03) 113-119
    CrossrefPubMedGoogle Scholar
  • 110 Wheeler AP, Bernard GR, Thompson BT. , et al; National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med 2006; 354 (21) 2213-2224
    CrossrefPubMedGoogle Scholar
  • 111 Mukhtar A, EL Masry A, Moniem AA, Metini M, Fayez A, Khater YH. The impact of maintaining normal serum albumin level following living related liver transplantation: does serum albumin level affect the course? A pilot study. Transplant Proc 2007; 39 (10) 3214-3218
    CrossrefPubMedGoogle Scholar
  • 112 Najeed SA, Saghir S, Hein B. , et al. Management of hypertension in liver transplant patients. Int J Cardiol 2011; 152 (01) 4-6
    CrossrefPubMedGoogle Scholar
  • 113 Błaszczyk B, Wrońska B, Klukowski M. , et al. Factors affecting breathing capacity and early tracheal extubation after liver transplantation: analysis of 506 cases. Transplant Proc 2016; 48 (05) 1692-1696
    CrossrefPubMedGoogle Scholar
  • 114 Mandell MS, Stoner TJ, Barnett R. , et al. A multicenter evaluation of safety of early extubation in liver transplant recipients. Liver Transpl 2007; 13 (11) 1557-1563
    CrossrefPubMedGoogle Scholar
  • 115 Skurzak S, Stratta C, Schellino MM. , et al. Extubation score in the operating room after liver transplantation. Acta Anaesthesiol Scand 2010; 54 (08) 970-978
    PubMedGoogle Scholar
  • 116 Mandell MS, Lezotte D, Kam I, Zamudio S. Reduced use of intensive care after liver transplantation: patient attributes that determine early transfer to surgical wards. Liver Transpl 2002; 8 (08) 682-687
    CrossrefPubMedGoogle Scholar
  • 117 Huang CT, Lin HC, Chang SC, Lee WC. Pre-operative risk factors predict post-operative respiratory failure after liver transplantation. PLoS One 2011; 6 (08) e22689
    CrossrefPubMedGoogle Scholar
  • 118 Glanemann M, Hoffmeister R, Neumann U. , et al. Fast tracking in liver transplantation: which patient benefits from this approach?. Transplant Proc 2007; 39 (02) 535-536
    CrossrefPubMedGoogle Scholar
  • 119 Glanemann M, Langrehr J, Kaisers U. , et al. Postoperative tracheal extubation after orthotopic liver transplantation. Acta Anaesthesiol Scand 2001; 45 (03) 333-339
    PubMedGoogle Scholar
  • 120 Biancofiore G, Romanelli AM, Bindi ML. , et al. Very early tracheal extubation without predetermined criteria in a liver transplant recipient population. Liver Transpl 2001; 7 (09) 777-782
    CrossrefPubMedGoogle Scholar
  • 121 Zeyneloglu P, Pirat A, Guner M, Torgay A, Karakayali H, Arslan G. Predictors of immediate tracheal extubation in the operating room after liver transplantation. Transplant Proc 2007; 39 (04) 1187-1189
    CrossrefPubMedGoogle Scholar
  • 122 Funk GC, Anders S, Breyer MK. , et al. Incidence and outcome of weaning from mechanical ventilation according to new categories. Eur Respir J 2010; 35 (01) 88-94
    CrossrefPubMedGoogle Scholar
  • 123 Peñuelas O, Frutos-Vivar F, Fernández C. , et al; Ventila Group. Characteristics and outcomes of ventilated patients according to time to liberation from mechanical ventilation. Am J Respir Crit Care Med 2011; 184 (04) 430-437
    CrossrefPubMedGoogle Scholar
  • 124 Yuan H, Tuttle-Newhall JE, Chawa V. , et al. Prognostic impact of mechanical ventilation after liver transplantation: a national database study. Am J Surg 2014; 208 (04) 582-590
    CrossrefPubMedGoogle Scholar
  • 125 Girard TD, Kress JP, Fuchs BD. , et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial. Lancet 2008; 371 (9607): 126-134
    CrossrefPubMedGoogle Scholar
  • 126 Blackwood B, Burns KE, Cardwell CR, O'Halloran P. Protocolized versus non-protocolized weaning for reducing the duration of mechanical ventilation in critically ill adult patients. Cochrane Database Syst Rev 2014; (11) CD006904
    PubMedGoogle Scholar
  • 127 Ferrer M, Valencia M, Nicolas JM, Bernadich O, Badia JR, Torres A. Early noninvasive ventilation averts extubation failure in patients at risk: a randomized trial. Am J Respir Crit Care Med 2006; 173 (02) 164-170
    CrossrefPubMedGoogle Scholar
  • 128 Nava S, Gregoretti C, Fanfulla F. , et al. Noninvasive ventilation to prevent respiratory failure after extubation in high-risk patients. Crit Care Med 2005; 33 (11) 2465-2470
    CrossrefPubMedGoogle Scholar
  • 129 Jaber S, Lescot T, Futier E. , et al; NIVAS Study Group. Effect of noninvasive ventilation on tracheal reintubation among patients with hypoxemic respiratory failure following abdominal surgery: a randomized clinical trial. JAMA 2016; 315 (13) 1345-1353
    CrossrefPubMedGoogle Scholar
  • 130 Hernández G, Vaquero C, Colinas L. , et al. Effect of postextubation high-flow nasal cannula vs noninvasive ventilation on reintubation and postextubation respiratory failure in high-risk patients: a randomized clinical trial. JAMA 2016; 316 (15) 1565-1574
    CrossrefPubMedGoogle Scholar
  • 131 Hernández G, Vaquero C, González P. , et al. Effect of postextubation high-flow nasal cannula vs conventional oxygen therapy on reintubation in low-risk patients: a randomized clinical trial. JAMA 2016; 315 (13) 1354-1361
    CrossrefPubMedGoogle Scholar
  • 132 Hong SK, Hwang S, Lee SG. , et al. Pulmonary complications following adult liver transplantation. Transplant Proc 2006; 38 (09) 2979-2981
    CrossrefPubMedGoogle Scholar
  • 133 Bozbas SS, Eyuboglu FO, Ozturk Ergur F. , et al. Pulmonary complications and mortality after liver transplant. Exp Clin Transplant 2008; 6 (04) 264-270
    PubMedGoogle Scholar
  • 134 Jiang GQ, Peng MH, Yang DH. Effect of perioperative fluid therapy on early phase prognosis after liver transplantation. Hepatobiliary Pancreat Dis Int 2008; 7 (04) 367-372
    PubMedGoogle Scholar
  • 135 Lin YH, Cai ZS, Jiang Y, Lü LZ, Zhang XJ, Cai QC. Perioperative risk factors for pulmonary complications after liver transplantation. J Int Med Res 2010; 38 (05) 1845-1855
    PubMedGoogle Scholar
  • 136 Pirat A, Ozgur S, Torgay A, Candan S, Zeyneloğlu P, Arslan G. Risk factors for postoperative respiratory complications in adult liver transplant recipients. Transplant Proc 2004; 36 (01) 218-220
    CrossrefPubMedGoogle Scholar
  • 137 Ranieri VM, Rubenfeld GD, Thompson BT. , et al; ARDS Definition Task Force. Acute respiratory distress syndrome: the Berlin definition. JAMA 2012; 307 (23) 2526-2533
    PubMedGoogle Scholar
  • 138 Meade MO, Cook DJ, Guyatt GH. , et al; Lung Open Ventilation Study Investigators. Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 2008; 299 (06) 637-645
    CrossrefPubMedGoogle Scholar
  • 139 Steinberg KP, Hudson LD, Goodman RB. , et al; National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med 2006; 354 (16) 1671-1684
    CrossrefPubMedGoogle Scholar
  • 140 Papazian L, Forel JM, Gacouin A. , et al; ACURASYS Study Investigators. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 2010; 363 (12) 1107-1116
    CrossrefPubMedGoogle Scholar
  • 141 Wiedemann HP, Wheeler AP, Bernard GR. , et al; National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med 2006; 354 (24) 2564-2575
    CrossrefPubMedGoogle Scholar
  • 142 Mercat A, Richard JC, Vielle B. , et al; Expiratory Pressure (Express) Study Group. Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 2008; 299 (06) 646-655
    CrossrefPubMedGoogle Scholar
  • 143 Guérin C, Reignier J, Richard JC. , et al; PROSEVA Study Group. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med 2013; 368 (23) 2159-2168
    CrossrefPubMedGoogle Scholar
  • 144 Brower RG, Matthay MA, Morris A, Schoenfeld D, Thompson BT, Wheeler A. ; Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000; 342 (18) 1301-1308
    CrossrefPubMedGoogle Scholar
  • 145 Feltracco P, Carollo C, Barbieri S, Pettenuzzo T, Ori C. Early respiratory complications after liver transplantation. World J Gastroenterol 2013; 19 (48) 9271-9281
    CrossrefPubMedGoogle Scholar
  • 146 Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000; 342 (18) 1334-1349
    CrossrefPubMedGoogle Scholar
  • 147 Li GS, Ye QF, Xia SS. , et al. Acute respiratory distress syndrome after liver transplantation: etiology, prevention and management. Hepatobiliary Pancreat Dis Int 2002; 1 (03) 330-334
    PubMedGoogle Scholar
  • 148 Zhao W, Ge X, Sun K. , et al. Acute respiratory distress syndrome after orthotopic liver transplantation. J Crit Care 2016; 31 (01) 163-167
    CrossrefPubMedGoogle Scholar
  • 149 Brower RG, Lanken PN, MacIntyre N. , et al; National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med 2004; 351 (04) 327-336
    CrossrefPubMedGoogle Scholar
  • 150 Aggarwal NR, Brower RG, Hager DN. , et al; National Institutes of Health Acute Respiratory Distress Syndrome Network Investigators. Oxygen exposure resulting in arterial oxygen tensions above the protocol goal was associated with worse clinical outcomes in acute respiratory distress syndrome. Crit Care Med 2018; 46 (04) 517-524
    PubMedGoogle Scholar
  • 151 Meduri GU, Golden E, Freire AX. , et al. Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial. Chest 2007; 131 (04) 954-963
    CrossrefPubMedGoogle Scholar
  • 152 Combes A, Hajage D, Capellier G. , et al; EOLIA Trial Group, REVA, and ECMONet. Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome. N Engl J Med 2018; 378 (21) 1965-1975
    CrossrefPubMedGoogle Scholar
  • 153 Young SY, Gunzenhauser JD, Malone KE, McTiernan A. Body mass index and asthma in the military population of the northwestern United States. Arch Intern Med 2001; 161 (13) 1605-1611
    CrossrefPubMedGoogle Scholar
  • 154 Taylor RW, Zimmerman JL, Dellinger RP. , et al; Inhaled Nitric Oxide in ARDS Study Group. Low-dose inhaled nitric oxide in patients with acute lung injury: a randomized controlled trial. JAMA 2004; 291 (13) 1603-1609
    CrossrefPubMedGoogle Scholar
  • 155 Ferguson ND, Cook DJ, Guyatt GH. , et al; OSCILLATE Trial Investigators; Canadian Critical Care Trials Group. High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med 2013; 368 (09) 795-805
    CrossrefPubMedGoogle Scholar
  • 156 Adhikari NK, Burns KE, Friedrich JO, Granton JT, Cook DJ, Meade MO. Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis. BMJ 2007; 334 (7597): 779
    CrossrefPubMedGoogle Scholar
  • 157 McAlister VC, Grant DR, Roy A. , et al. Right phrenic nerve injury in orthotopic liver transplantation. Transplantation 1993; 55 (04) 826-830
    CrossrefPubMedGoogle Scholar
  • 158 Ford GT, Rosenal TW, Clergue F, Whitelaw WA. Respiratory physiology in upper abdominal surgery. Clin Chest Med 1993; 14 (02) 237-252
    PubMedGoogle Scholar
  • 159 Nayyar D, Man HS, Granton J, Lilly LB, Gupta S. Proposed management algorithm for severe hypoxemia after liver transplantation in the hepatopulmonary syndrome. Am J Transplant 2015; 15 (04) 903-913
    CrossrefPubMedGoogle Scholar
  • 160 Meyers C, Low L, Kaufman L, Druger G, Wong LL. Trendelenburg positioning and continuous lateral rotation improve oxygenation in hepatopulmonary syndrome after liver transplantation. Liver Transpl Surg 1998; 4 (06) 510-512
    CrossrefPubMedGoogle Scholar
  • 161 Jounieaux V, Leleu O, Mayeux I. Cardiopulmonary effects of nitric oxide inhalation and methylene blue injection in hepatopulmonary syndrome. Intensive Care Med 2001; 27 (06) 1103-1104
    CrossrefPubMedGoogle Scholar
  • 162 Schenk P, Madl C, Rezaie-Majd S, Lehr S, Müller C. Methylene blue improves the hepatopulmonary syndrome. Ann Intern Med 2000; 133 (09) 701-706
    PubMedGoogle Scholar
  • 163 Rolla G, Bucca C, Brussino L. Methylene blue in the hepatopulmonary syndrome. N Engl J Med 1994; 331 (16) 1098
    PubMedGoogle Scholar
  • 164 Santos J, Young P, Barjaktarevic I, Lazar C, Susanto I, Wang T. The successful use of inhaled nitric oxide in the management of severe hepatopulmonary syndrome after orthotopic liver transplantation. Case Reports Hepatol 2014; 2014: 415109
    PubMedGoogle Scholar
  • 165 Ruan SY, Huang TM, Wu HY, Wu HD, Yu CJ, Lai MS. Inhaled nitric oxide therapy and risk of renal dysfunction: a systematic review and meta-analysis of randomized trials. Crit Care 2015; 19: 137
    CrossrefPubMedGoogle Scholar
  • 166 Roma J, Balbi E, Pacheco-Moreira L. , et al. Methylene blue used as a bridge to liver transplantation postoperative recovery: a case report. Transplant Proc 2010; 42 (02) 601-604
    CrossrefPubMedGoogle Scholar
  • 167 Khan HH, Schroeder L, Fitzpatrick MS. , et al. Successful venoarterial extracorporeal membrane oxygenation for prolonged hepatopulmonary syndrome following pediatric liver transplantation: a case report and review of the literature. Pediatr Transplant 2017 21(07):
    PubMedGoogle Scholar
  • 168 Fleming GM, Cornell TT, Welling TH, Magee JC, Annich GM. Hepatopulmonary syndrome: use of extracorporeal life support for life-threatening hypoxia following liver transplantation. Liver Transpl 2008; 14 (07) 966-970
    CrossrefPubMedGoogle Scholar
  • 169 Pereira JLF, Galant LH, Garcia E, Rosa LH, Brandão ABM, Marroni CA. Ventilatory support and hospital stay after liver transplant in cirrhotic patients with hepatopulmonary syndrome. Einstein (Sao Paulo) 2017; 15 (03) 322-326
    CrossrefPubMedGoogle Scholar
  • 170 De BK, Dutta D, Pal SK, Gangopadhyay S, Das Baksi S, Pani A. The role of garlic in hepatopulmonary syndrome: a randomized controlled trial. Can J Gastroenterol 2010; 24 (03) 183-188
    CrossrefPubMedGoogle Scholar
  • 171 Abrams GA, Fallon MB. Treatment of hepatopulmonary syndrome with Allium sativum L. (garlic): a pilot trial. J Clin Gastroenterol 1998; 27 (03) 232-235
    CrossrefPubMedGoogle Scholar
  • 172 Gupta LB, Kumar A, Jaiswal AK. , et al. Pentoxifylline therapy for hepatopulmonary syndrome: a pilot study. Arch Intern Med 2008; 168 (16) 1820-1823
    CrossrefPubMedGoogle Scholar
  • 173 Hollatz TJ, Musat A, Westphal S. , et al. Treatment with sildenafil and treprostinil allows successful liver transplantation of patients with moderate to severe portopulmonary hypertension. Liver Transpl 2012; 18 (06) 686-695
    CrossrefPubMedGoogle Scholar
  • 174 Bozbas SS, Bozbas H. Portopulmonary hypertension in liver transplant candidates. World J Gastroenterol 2016; 22 (06) 2024-2029
    CrossrefPubMedGoogle Scholar
  • 175 Fischer LG, Van Aken H, Bürkle H. Management of pulmonary hypertension: physiological and pharmacological considerations for anesthesiologists. Anesth Analg 2003; 96 (06) 1603-1616
    PubMedGoogle Scholar
  • 176 Harjola VP, Mebazaa A, Čelutkienė J. , et al. Contemporary management of acute right ventricular failure: a statement from the Heart Failure Association and the Working Group on Pulmonary Circulation and Right Ventricular Function of the European Society of Cardiology. Eur J Heart Fail 2016; 18 (03) 226-241
    CrossrefPubMedGoogle Scholar