Early-Onset Neonatal Sepsis with Extended Spectrum Beta-Lactamase Producing Escherichia Coli in Infants Born to South and South East Asian Immigrants: A Case Series

Kalsang Dolma; Thanh L. Summerlin; Hansa Wongprasert; Charitharth Vivek Lal; Joseph B. Philips III; Lindy Winter

doi:10.1055/s-0038-1675336

American Journal of Perinatology Reports, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · AJP Rep 2018; 08(04): e277-e279
DOI: 10.1055/s-0038-1675336

Case Report

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Early-Onset Neonatal Sepsis with Extended Spectrum Beta-Lactamase Producing Escherichia Coli in Infants Born to South and South East Asian Immigrants: A Case Series

Kalsang Dolma

¹Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama

,

Thanh L. Summerlin

¹Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama

,

Hansa Wongprasert

¹Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama

,

Charitharth Vivek Lal

¹Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama

,

Joseph B. Philips III

¹Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama

,

Lindy Winter

¹Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama

› Institutsangaben

Abstract

Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae represent a major worldwide threat. We present three cases of early onset ESBL Escherichia coli sepsis in infants born to families from South and Southeast Asia to inform the practitioner community about this emerging threat. Infants with suspected sepsis, whose mother is from Asia or Southeast Asia, should be suspected of having an infection with an ESBL-producing organism, and practitioners should strongly consider adding a carbapenem to their usual initial antibiotic regimen.

Keywords

neonatal sepsis - early onset sepsis - extended-spectrum β-lactamases - Escherichia coli

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Referenzen

References
1 Paterson DL, Bonomo RA. Extended-spectrum beta-lactamases: a clinical update. Clin Microbiol Rev 2005; 18 (04) 657-686
2 Bush K, Jacoby GA. Updated functional classification of beta-lactamases. Antimicrob Agents Chemother 2010; 54 (03) 969-976
3 Flokas ME, Karanika S, Alevizakos M, Mylonakis E. Prevalence of ESBL-producing Enterobacteriaceae in pediatric bloodstream infections: a systematic review and meta-analysis. PLoS One 2017; 12 (01) e0171216
4 Bradford PA. Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. Clin Microbiol Rev 2001; 14 (04) 933-951
5 Kliebe C, Nies BA, Meyer JF, Tolxdorff-Neutzling RM, Wiedemann B. Evolution of plasmid-coded resistance to broad-spectrum cephalosporins. Antimicrob Agents Chemother 1985; 28 (02) 302-307
6 Jacoby GA, Medeiros AA, O'Brien TF, Pinto ME, Jiang H. Broad-spectrum, transmissible beta-lactamases. N Engl J Med 1988; 319 (11) 723-724
7 Logan LK, Braykov NP, Weinstein RA, Laxminarayan R, Program CDCEP. ; CDC Epicenters Prevention Program. Extended-spectrum β-lactamase-producing and third-generation cephalosporin-resistant Enterobacteriaceae in children: trends in the United States, 1999-2011. J Pediatric Infect Dis Soc 2014; 3 (04) 320-328
8 Karanika S, Karantanos T, Arvanitis M, Grigoras C, Mylonakis E. Fecal colonization with extended-spectrum beta-lactamase-producing Enterobacteriaceae and risk factors among healthy individuals: a systematic review and metaanalysis. Clin Infect Dis 2016; 63 (03) 310-318
9 Nguyen VT, Carrique-Mas JJ, Ngo TH. , et al. Prevalence and risk factors for carriage of antimicrobial-resistant Escherichia coli on household and small-scale chicken farms in the Mekong Delta of Vietnam. J Antimicrob Chemother 2015; 70 (07) 2144-2152
10 Jiang HX, Tang D, Liu YH. , et al. Prevalence and characteristics of β-lactamase and plasmid-mediated quinolone resistance genes in Escherichia coli isolated from farmed fish in China. J Antimicrob Chemother 2012; 67 (10) 2350-2353
11 Chen PA, Hung CH, Huang PC. , et al. Characteristics of CTX-M extended-spectrum β-lactamase-producing Escherichia coli strains isolated from multiple rivers in southern Taiwan. Appl Environ Microbiol 2016; 82 (06) 1889-1897
12 Bajaj P, Kanaujia PK, Singh NS, Sharma S, Kumar S, Virdi JS. Quinolone co-resistance in ESBL- or AmpC-producing Escherichia coli from an Indian urban aquatic environment and their public health implications. Environ Sci Pollut Res Int 2016; 23 (02) 1954-1959
13 Kuenzli E, Jaeger VK, Frei R. , et al. High colonization rates of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli in Swiss travellers to South Asia–a prospective observational multicentre cohort study looking at epidemiology, microbiology and risk factors. BMC Infect Dis 2014; 14: 528
14 Ostholm-Balkhed A, Tärnberg M, Nilsson M, Nilsson LE, Hanberger H, Hällgren A. ; Travel Study Group of Southeast Sweden. Travel-associated faecal colonization with ESBL-producing Enterobacteriaceae: incidence and risk factors. J Antimicrob Chemother 2013; 68 (09) 2144-2153
15 Lübbert C, Straube L, Stein C. , et al. Colonization with extended-spectrum beta-lactamase-producing and carbapenemase-producing Enterobacteriaceae in international travelers returning to Germany. Int J Med Microbiol 2015; 305 (01) 148-156
16 Barreto Miranda I, Ignatius R, Pfüller R. , et al. High carriage rate of ESBL-producing Enterobacteriaceae at presentation and follow-up among travellers with gastrointestinal complaints returning from India and Southeast Asia. J Travel Med 2016; 23 (02) tav024
17 Ben-Ami R, Rodríguez-Baño J, Arslan H. , et al. A multinational survey of risk factors for infection with extended-spectrum beta-lactamase-producing Enterobacteriaceae in nonhospitalized patients. Clin Infect Dis 2009; 49 (05) 682-690
18 Pitout JD, Gregson DB, Church DL, Elsayed S, Laupland KB. Community-wide outbreaks of clonally related CTX-M-14 beta-lactamase-producing Escherichia coli strains in the Calgary health region. J Clin Microbiol 2005; 43 (06) 2844-2849
19 Rodríguez-Baño J, Navarro MD, Romero L. , et al. Epidemiology and clinical features of infections caused by extended-spectrum beta-lactamase-producing Escherichia coli in nonhospitalized patients. J Clin Microbiol 2004; 42 (03) 1089-1094
20 Doi Y, Park YS, Rivera JI. , et al. Community-associated extended-spectrum β-lactamase-producing Escherichia coli infection in the United States. Clin Infect Dis 2013; 56 (05) 641-648
21 Sehgal R, Gaind R, Chellani H, Agarwal P. Extended-spectrum beta lactamase-producing gram-negative bacteria: clinical profile and outcome in a neonatal intensive care unit. Ann Trop Paediatr 2007; 27 (01) 45-54
22 Kimberlin DW, Brady MT, Jackson MA. , eds. Red Book 2018–2021: Report of the Committee on Infectious Diseases, 31st ed. Elk Grove Village, IL: American Academy of Pediatrics; 2018