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Am J Perinatol 2019; 36(10): 1039-1044
DOI: 10.1055/s-0038-1676114
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Interdelivery Interval and Diabetes Mellitus in a Subsequent Pregnancy

Annie M. Dude
1   Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Chicago, Illinois
,
Ashley Battarbee
2   Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina
,
Lynn M. Yee
1   Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Chicago, Illinois
› Author Affiliations Funding Research reported in this publication was supported, in part, by the National Institutes of Health's National Center for Advancing Translational Sciences, Grant Number UL1TR001422. L.M.Y. is supported by the NICHD K12 HD050121-11. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Further Information

Publication History

06 September 2018

19 October 2018

Publication Date:
30 November 2018 (online)

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Abstract

Objective We determined whether time between deliveries is associated with developing diabetes at the time of a subsequent delivery.

Study Design This is a case–control study of women who had two consecutive singleton births at the same institution with no pregestational diabetes in the baseline pregnancy. Cases were defined as women who were diagnosed with any type of diabetes at the time of the subsequent delivery. Controls were defined as women who had no diagnosis of diabetes at the time of the subsequent delivery. Interdelivery interval (IDI) was categorized as < 18, 18 to 60, or > 60 months.

Results Of 12,263 women, 4.1% (N = 501) were diagnosed with diabetes at the subsequent delivery. Women with diabetes were more likely to have an IDI of >60 months than women without diabetes (9.0 vs. 4.2%, p < 0.001). After controlling for confounding factors, an IDI > 60 months remained associated with development of pregestational or gestational diabetes by the conclusion of the subsequent pregnancy (adjusted odds ratio = 2.13 compared with an IDI of 18–60 months, 95% confidence interval 1.44–3.15).

Conclusion A longer IDI is an independent risk factor for the development of diabetes at the time of a subsequent delivery.

Keywords

gestational diabetes - interdelivery interval - pregestational diabetes

Note

Portions of this article were presented at the 64th Annual Scientific Meeting of the Society for Reproductive Investigation, Orlando, FL, March 15–18, 2017, and the 15th Biannual Meeting of the Diabetes in Pregnancy Study Group of North America, Washington, DC, October 27–29, 2017.


 

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