Geographical Differences in Intracranial Meningioma Management: Examining 65,973 Patients across the United States

Charles Lane Anzalone; Amy Glasgow; Elizabeth Habermann; Brandon R. Grossard; Jamie J. Van Gompel; Matthew L. Carlson

doi:10.1055/s-0038-1676376

Journal of Neurological Surgery Part B: Skull Base, Table of Contents

J Neurol Surg B Skull Base 2019; 80(06): 547-554
DOI: 10.1055/s-0038-1676376

Original Article

Georg Thieme Verlag KG Stuttgart · New York

Geographical Differences in Intracranial Meningioma Management: Examining 65,973 Patients across the United States

Charles Lane Anzalone

¹Department of Otorhinolaryngology - Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, United States

,

Amy Glasgow

²Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery Surgical Outcomes Program, Mayo Clinic, Rochester, Minnesota, United States

,

Elizabeth Habermann

²Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery Surgical Outcomes Program, Mayo Clinic, Rochester, Minnesota, United States

,

Brandon R. Grossard

³Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota, United States

,

Jamie J. Van Gompel

⁴Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, United States

,

Matthew L. Carlson

¹Department of Otorhinolaryngology - Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, United States

› Author Affiliations

Abstract

Background Age, tumor size and location, overall health, and patient preference are primary considerations driving treatment decision-making for intracranial meningiomas. However, even for the same individual patient, treatment recommendations may vary between centers and providers.

Objective To study associations between geography, disease presentation, and management of intracranial meningioma in the United States.

Methods The population-based Surveillance, Epidemiology, and End Results(SEER) data were queried between 2004 and 2014 for cases of intracranial meningioma.

Results A total of 65,808 patients with intracranial meningioma were identified. Univariate analyses demonstrated strong associations between geographic location, age, and size of tumor at presentation. The mean age for all registries was 64.2 years, with a range from 62.0 (Utah registry) to 66.6 (Detroit registry). The greatest proportion of small tumors (<1 cm) were identified in the Utah registry (13.9% of tumors), while the greatest proportion of large tumors (> 4cm) were noted in the Hawaii registry (30.7% of tumors). Multivariable analysis demonstrated that the impact of geography on treatment selection was just as important as other established variables. For example, the distribution in tumor size between New Mexico and Greater California registries is nearly identical; however, the odds ratio for surgery was 1.5 times greater for the New Mexico population.

Conclusion These data suggest that disease presentation and treatment are significantly influenced by regional referral patterns, provider or institutional treatment preferences, and regional availability of subspecialty expertise. Understanding such biases is important for patients, referring physicians, and treatment providers in an effort to provide balanced counseling and treatment.

Keywords

skull base - meningioma - intracranial - regional

Full Text

References

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