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Thromb Haemost 2019; 119(01): 077-086
DOI: 10.1055/s-0038-1676518
Coagulation and Fibrinolysis
Georg Thieme Verlag KG Stuttgart · New York

tPA Point Mutation at Autolysis Loop Enhances Resistance to PAI-1 Inhibition and Catalytic Activity

Authors

  • Shuangzhou Peng

    1   College of Chemistry, Fuzhou University, Fuzhou, Fujian, People's Republic of China
    2   State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, People's Republic of China
    3   University of Chinese Academy of Sciences, Beijing, People's Republic of China
  • Guangpu Xue

    1   College of Chemistry, Fuzhou University, Fuzhou, Fujian, People's Republic of China
  • Shanli Chen

    1   College of Chemistry, Fuzhou University, Fuzhou, Fujian, People's Republic of China
  • Zhuo Chen

    2   State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, People's Republic of China
  • Cai Yuan

    4   College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian, People's Republic of China
  • Jinyu Li

    1   College of Chemistry, Fuzhou University, Fuzhou, Fujian, People's Republic of China
  • Mingdong Huang

    1   College of Chemistry, Fuzhou University, Fuzhou, Fujian, People's Republic of China
    2   State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, People's Republic of China