Can Platelet Mass Index Be a Parameter to Predict Intraventricular Hemorrhage in Very-Low-Birth-Weight Newborns?

Levent Korkmaz; Osman Bastug; Ahmet Ozdemir; Mahir Ceylan; Tamer Gunes; Mehmet Adnan Ozturk; Sabriye Korkut

doi:10.1055/s-0038-1676535

American Journal of Perinatology, Table of Contents

Am J Perinatol 2019; 36(11): 1188-1197
DOI: 10.1055/s-0038-1676535

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Can Platelet Mass Index Be a Parameter to Predict Intraventricular Hemorrhage in Very-Low-Birth-Weight Newborns?

Authors

Levent Korkmaz

¹Neonatalogy Unit, Malatya Training and Research Hospital, Malatya, Turkey
Osman Bastug

²Neonatalogy Unit, Kayseri Training and Research Hospital, Kayseri, Turkey
Ahmet Ozdemir

²Neonatalogy Unit, Kayseri Training and Research Hospital, Kayseri, Turkey
Mahir Ceylan

³Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri, Turkey
Tamer Gunes

³Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri, Turkey
Mehmet Adnan Ozturk

³Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri, Turkey
Sabriye Korkut

³Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri, Turkey

Abstract

Objective Intraventricular hemorrhage (IVH) is an important problem in neonatal units not only in terms of its consequences but also its follow-up and the prediction of its emergence in newborns. In this study, we have compared platelet parameters such as platelet count (PC), mean platelet volume (MPV), and platelet mass index (PMI) in terms of IHV in very-low-birth-weight (VLBW) newborns. Thus, we have tried to determine platelet values to guide clinicians in both the prediction and follow-up of IVH.

Study Design This is a retrospective, multicenter, and case-controlled study. In this study, 386 cases of VLBW newborns (below 1,500 g) and gestational age below 32 weeks, hospitalized and monitored between August 8, 2012, and April 7, 2018, were included. The platelet values of the cases on their 12th hour postpartum (PC₁, MPV₁, and PMI₁) and the platelet values on days 5 to 7 (PC₂, MPV₂, and PMI₂) were recorded in their study cards. A p-value of <0.05 was accepted as statistically significant.

Results While there was no difference of PC₁, MPV₁, PMI₁, PC₂, or MPV₂ values (p > 0.05), PMI₂ values in the severe stage IVH group cases were found to be significantly lower compared with other platelet parameters (p < 0.05).

Conclusion PMI₂ values can provide clinicians with important knowledge that may aid them in recognizing important pathologies such as IVH.

Keywords

very-low-birth-weight newborn - intraventricular hemorrhage - platelet values - mean platelet volume - platelet mass index

Full Text

References

References
1 Al-Abdi SY, Al-Aamri MA. A systematic review and metaanalysis of the timing of early intraventricular hemorrhage in preterm neonates: clinical and research implications. J Clin Neonatol 2014; 3 (02) 76-88
2 Synnes AR, Chien LY, Peliowski A, Baboolal R, Lee SK. ; Canadian NICU Network. Variations in intraventricular hemorrhage incidence rates among Canadian neonatal intensive care units. J Pediatr 2001; 138 (04) 525-531
3 Shankaran S, Lin A, Maller-Kesselman J. , et al; Gene Targets for Intraventricular Hemorrhage Study. Maternal race, demography, and health care disparities impact risk for intraventricular hemorrhage in preterm neonates. J Pediatr 2014; 164 (05) 1005-1011
4 Mitsiakos G, Papathanasiou AE, Kyriakidis I. , et al. Intraventricular hemorrhage and platelet indices in extremely premature neonates. J Pediatr Hematol Oncol 2016; 38 (07) 533-538
5 Lee JY, Kim HS, Jung E. , et al. Risk factors for periventricular-intraventricular hemorrhage in premature infants. J Korean Med Sci 2010; 25 (03) 418-424
6 Zisk JL, Mackley A, Christensen RD, Paul DA. Is a small platelet mass associated with intraventricular hemorrhage in very low-birth-weight infants?. J Perinatol 2011; 31 (12) 776-779
7 Okur N, Buyuktiryaki M, Uras N. , et al. Platelet mass index in very preterm infants: can it be used as a parameter for neonatal morbidities?. J Matern Fetal Neonatal Med 2016; 29 (19) 3218-3222
8 Gerday E, Baer VL, Lambert DK. , et al. Testing platelet mass versus platelet count to guide platelet transfusions in the neonatal intensive care unit. Transfusion 2009; 49 (10) 2034-2039
9 Korkmaz L, Baştuğ O, Özdemir A. , et al. Platelet mass index can be a reliable marker in predicting the prognosis of retinopathy of prematurity in very preterm infants. Pediatr Neonatol 2018; 59 (05) 455-463
10 Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr 1978; 92 (04) 529-534
11 Narang I. Review series: what goes around, comes around: childhood influences on later lung health? Long-term follow-up of infants with lung disease of prematurity. Chron Respir Dis 2010; 7 (04) 259-269
12 Bernstein IM, Horbar JD, Badger GJ, Ohlsson A, Golan A. ; The Vermont Oxford Network. Morbidity and mortality among very-low-birth-weight neonates with intrauterine growth restriction. Am J Obstet Gynecol 2000; 182 (1 Pt 1): 198-206
13 ACOG Committee on Obstetric Practice. ACOG practice bulleting. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002, American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet 2002; 77 (01) 67-75
14 American College of Obstetricians and Gynecologists. American Academy of Pediatrics. Background. In: Neonatal Encephalopathy and Cerebral Palsy: Defining the Pathogenesis and Pathophysiology. Washington, DC: American College of Obstetricians and Gynecologists Distribution Center; 2003: 1-11
15 Hamrick SE, Hansmann G. Patent ductus arteriosus of the preterm infant. Pediatrics 2010; 125 (05) 1020-1030
16 Lucas A, Morley R, Cole TJ. Adverse neurodevelopmental outcome of moderate neonatal hypoglycaemia. BMJ 1988; 297 (6659): 1304-1308
17 Hemachandra AH, Cowett RM. Neonatal hyperglycemia. Pediatr Rev 1999; 20: 16-24
18 Bell MJ, Ternberg JL, Feigin RD. , et al. Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging. Ann Surg 1978; 187 (01) 1-7
19 Töllner U. Early diagnosis of septicemia in the newborn. Clinical studies and sepsis score. Eur J Pediatr 1982; 138 (04) 331-337
20 Italiano Jr JE, Richardson JL, Patel-Hett S. , et al. Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released. Blood 2008; 111 (03) 1227-1233
21 Bonifacio SL, Gonzalez F, Ferriero DM. Central nervous system injury and neuroprotection Avery's Diseases of the Newborn, 9th ed. Los Angeles, CA: Saunders; 2012: 869-891
22 Volpe JJ. Intracranial hemorrhage: germinal matrix-intraventricular hemorrhage of the prematüre infant. Neurology of the Newborn, 5th ed. Philadelphia: Saunders; 2001: 517-588
23 Sears JE, Hoppe G, Ebrahem Q, Anand-Apte B. Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy. Proc Natl Acad Sci U S A 2008; 105 (50) 19898-19903
24 DeNiro M, Al-Mohanna FH, Al-Mohanna FA. Inhibition of reactive gliosis prevents neovascular growth in the mouse model of oxygen-induced retinopathy. PLoS One 2011; 6 (07) e22244
25 Korkmaz L, Baştuğ O, Ozdemir A. , et al. The efficacy of propranolol in retinopathy of prematurity and its correlation with the platelet mass index. Curr Eye Res 2017; 42 (01) 88-97
26 D'Amore P, Shepro D. Stimulation of growth and calcium influx in cultured, bovine, aortic endothelial cells by platelets and vasoactive substances. J Cell Physiol 1977; 92 (02) 177-183
27 Pipili-Synetos E, Papadimitriou E, Maragoudakis ME. Evidence that platelets promote tube formation by endothelial cells on matrigel. Br J Pharma 1998; 125: 1252-1257
28 Sapieha P, Joyal JS, Rivera JC. , et al. Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life. J Clin Invest 2010; 120 (09) 3022-3032
29 Oak P, Hilgendorff A. The BPD trio? Interaction of dysregulated PDGF, VEGF, and TGF signaling in neonatal chronic lung disease. Mol Cell Pediatr 2017; 4 (01) 11
30 Chen NF, Sung CS, Wen ZH. , et al. Therapeutic effect of platelet-rich plasma in rat spinal cord injuries. Front Neurosci 2018; 12: 252
31 Nurden AT. Platelets, inflammation and tissue regeneration. Thromb Haemost 2011; 105 (Suppl. 01) S13-S33
32 Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med 2001; 163 (07) 1723-1729
33 Gandhi S, Abramov AY. Mechanism of oxidative stress in neurodegeneration. Oxid Med Cell Longev 2012; 2012: 428010
34 Baburamani AA, Ek CJ, Walker DW, Castillo-Melendez M. Vulnerability of the developing brain to hypoxic-ischemic damage: contribution of the cerebral vasculature to injury and repair?. Front Physiol 2012; 3: 424
35 Kuwano T, Nakao S, Yamamoto H. , et al. Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis. FASEB J 2004; 18 (02) 300-310
36 Wang J, Dong W. Oxidative stress and bronchopulmonary dysplasia. Gene 2018; 678: 177-183
37 Vento M, Moro M, Escrig R. , et al. Preterm resuscitation with low oxygen causes less oxidative stress, inflammation, and chronic lung disease. Pediatrics 2009; 124 (03) e439-e449
38 Keller RL, Ballard RA. Bronchopulmonary dysplasia. Avery's Diseases of the Newborn, 9th ed. Los Angeles, CA: Saunders; 2012: 658-671
39 Inder TE, Graham P, Sanderson K, Taylor BJ. Lipid peroxidation as a measure of oxygen free radical damage in the very low birthweight infant. Arch Dis Child Fetal Neonatal Ed 1994; 70 (02) F107-F111