Monocyte Chemoattractant Protein (MCP)-1 in Rotavirus-Associated White Matter Injury in Newborns

Jung Sook Yeom; Jae-Young Jo; Ji Sook Park; Young-Soo Kim; Ju-Young Chung; Tae-Hee Han; Ji-Hyun Seo; Eun Sil Park; Jae-Young Lim; Hyang-Ok Woo; Hee-Shang Youn; Chan-Hoo Park

doi:10.1055/s-0038-1677516

Neuropediatrics, Table of Contents

Neuropediatrics 2019; 50(04): 228-234
DOI: 10.1055/s-0038-1677516

Original Article

Georg Thieme Verlag KG Stuttgart · New York

Monocyte Chemoattractant Protein (MCP)-1 in Rotavirus-Associated White Matter Injury in Newborns

Jung Sook Yeom

¹Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea

²Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea

,

Jae-Young Jo

³Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea

,

Ji Sook Park

¹Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea

²Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea

,

Young-Soo Kim

⁴Department of Neurology, Gyeongsang National University School of Medicine, Jinju, Republic of Korea

,

Ju-Young Chung

⁵Department of Pediatrics, Sanggyepaik Hospital, Inje University College of Medicine, Seoul, Republic of Korea

,

Tae-Hee Han

⁶Department of Diagnostic Laboratory Medicine, Sanggyepaik Hospital, Inje University College of Medicine, Seoul, Republic of Korea

,

Ji-Hyun Seo

¹Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea

²Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea

,

Eun Sil Park

¹Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea

²Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea

,

Jae-Young Lim

¹Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea

²Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea

,

Hyang-Ok Woo

¹Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea

²Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea

,

Hee-Shang Youn

¹Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea

²Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea

,

Chan-Hoo Park

²Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea

⁷Department of Pediatrics, Changwon Gyeongsang National University Hospital, Changwon, Republic of Korea

› Author Affiliations

Abstract

Recent reports have suggested an association between rotavirus infection and a distinctive pattern of white matter injury (WMI) in neonates with seizures; however, the connection between the two is not fully understood. To evaluate the underlying mechanism, we profiled and compared eight cytokines (IL [interleukin]-1β, IL-6, IL-8, IL-10, IFN-γ [interferon-γ ], MCP-1 [monocyte chemoattractant protein-1], MIP-1β [macrophage inflammatory protein-1β], and TNF-α [tumor necrosis factor-α]) in the cerebrospinal fluid (CSF) of 33 neonates with seizures who had no other well-known causes of seizures and 13 control patients (rotavirus-induced gastroenteritis but without seizures). Among the 33 neonates with seizures, 9 showed WMI and all were infected with rotavirus (R + W + ). Among the 24 patients without WMI, 11 were infected with rotavirus (R + W − ) and 13 were not (R − W − ).Only MCP-1 and MIP-1β were different between the groups. MCP-1 was increased in R+ W+ compared with R + W− (p < 0.01), R − W− (p < 0.01), and control (p = 0.03) patients. MIP-1β was decreased in R + W+ compared with R − W− (p < 0.01) and control (p < 0.01), but not R + W− (p = 0.23) patients. MCP-1 and MIP-1β are C-C chemokines that recruit immune cells to the site of inflammation. Our pilot study suggests MCP-1-mediated monocyte recruitment may be linked with this complication caused by rotavirus.

Keywords

cytokines - neonates - rotavirus - seizure

Full Text

References

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Supplementary Material

Supplementary Material