Download PDF
Neuropediatrics 2019; 50(04): 228-234
DOI: 10.1055/s-0038-1677516
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Monocyte Chemoattractant Protein (MCP)-1 in Rotavirus-Associated White Matter Injury in Newborns

Jung Sook Yeom
1   Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
2   Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
,
Jae-Young Jo
3   Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea
,
Ji Sook Park
1   Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
2   Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
,
Young-Soo Kim
4   Department of Neurology, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
,
Ju-Young Chung
5   Department of Pediatrics, Sanggyepaik Hospital, Inje University College of Medicine, Seoul, Republic of Korea
,
Tae-Hee Han
6   Department of Diagnostic Laboratory Medicine, Sanggyepaik Hospital, Inje University College of Medicine, Seoul, Republic of Korea
,
Ji-Hyun Seo
1   Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
2   Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
,
Eun Sil Park
1   Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
2   Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
,
Jae-Young Lim
1   Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
2   Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
,
Hyang-Ok Woo
1   Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
2   Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
,
Hee-Shang Youn
1   Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
2   Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
,
Chan-Hoo Park
2   Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
7   Department of Pediatrics, Changwon Gyeongsang National University Hospital, Changwon, Republic of Korea
› Author Affiliations Funding The biospecimens and data used for this study were provided by the Gyeongsang National University Hospital, a member of the Korea Biobank Network. This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT & Future Planning (grant number 2015-0578).
Further Information

Publication History

18 July 2018

09 December 2018

Publication Date:
02 April 2019 (online)

Also available at
    Permissions and Reprints

Abstract

Recent reports have suggested an association between rotavirus infection and a distinctive pattern of white matter injury (WMI) in neonates with seizures; however, the connection between the two is not fully understood. To evaluate the underlying mechanism, we profiled and compared eight cytokines (IL [interleukin]-1β, IL-6, IL-8, IL-10, IFN-γ [interferon-γ ], MCP-1 [monocyte chemoattractant protein-1], MIP-1β [macrophage inflammatory protein-1β], and TNF-α [tumor necrosis factor-α]) in the cerebrospinal fluid (CSF) of 33 neonates with seizures who had no other well-known causes of seizures and 13 control patients (rotavirus-induced gastroenteritis but without seizures). Among the 33 neonates with seizures, 9 showed WMI and all were infected with rotavirus (R + W + ). Among the 24 patients without WMI, 11 were infected with rotavirus (R + W − ) and 13 were not (R − W − ).Only MCP-1 and MIP-1β were different between the groups. MCP-1 was increased in R+ W+ compared with R + W− (p < 0.01), R − W− (p < 0.01), and control (p = 0.03) patients. MIP-1β was decreased in R + W+ compared with R − W− (p < 0.01) and control (p < 0.01), but not R + W− (p = 0.23) patients. MCP-1 and MIP-1β are C-C chemokines that recruit immune cells to the site of inflammation. Our pilot study suggests MCP-1-mediated monocyte recruitment may be linked with this complication caused by rotavirus.

Keywords

cytokines - neonates - rotavirus - seizure

Supplementary Material

 

  • References

  • 1 Yeom JS, Kim YS, Seo JH. , et al. Distinctive pattern of white matter injury in neonates with rotavirus infection. Neurology 2015; 84 (01) 21-27
    CrossrefPubMedSearch in Google Scholar
  • 2 Oh KW, Moon CH, Lee KY. Association of rotavirus with seizures accompanied by cerebral white matter injury in neonates. J Child Neurol 2015; 30 (11) 1433-1439
    CrossrefPubMedSearch in Google Scholar
  • 3 Lee KY, Oh KW, Weon YC, Choi SH. Neonatal seizures accompanied by diffuse cerebral white matter lesions on diffusion-weighted imaging are associated with rotavirus infection. Eur J Paediatr Neurol 2014; 18 (05) 624-631
    CrossrefPubMedSearch in Google Scholar
  • 4 Yeom JS, Park CH. White matter injury following rotavirus infection in neonates: new aspects to a forgotten entity, ‘fifth day fits’?. Korean J Pediatr 2016; 59 (07) 285-291
    CrossrefPubMedSearch in Google Scholar
  • 5 Lee KY, Moon CH, Choi SH. Type I interferon and proinflammatory cytokine levels in cerebrospinal fluid of newborns with rotavirus-associated leukoencephalopathy. Brain Dev 2018; 40 (03) 211-217
    CrossrefPubMedSearch in Google Scholar
  • 6 Peiravian F, Rajaian H, Samiei A. , et al. Altered serum cytokine profiles in relapse phase of relapsing-remitting multiple sclerosis. Iran J Immunol 2016; 13 (03) 186-196
    PubMedSearch in Google Scholar
  • 7 Villena J, Vizoso-Pinto MG, Kitazawa H. Intestinal innate antiviral immunity and immunobiotics: beneficial effects against rotavirus infection. Front Immunol 2016; 7: 563
    PubMedSearch in Google Scholar
  • 8 Jiang B, Snipes-Magaldi L, Dennehy P. , et al. Cytokines as mediators for or effectors against rotavirus disease in children. Clin Diagn Lab Immunol 2003; 10 (06) 995-1001
    CrossrefPubMedSearch in Google Scholar
  • 9 Rollo EE, Kumar KP, Reich NC. , et al. The epithelial cell response to rotavirus infection. J Immunol 1999; 163 (08) 4442-4452
    PubMedSearch in Google Scholar
  • 10 Hoogland IC, Houbolt C, van Westerloo DJ, van Gool WA, van de Beek D. Systemic inflammation and microglial activation: systematic review of animal experiments. J Neuroinflammation 2015; 12: 114
    CrossrefPubMedSearch in Google Scholar
  • 11 Fladby T, Bjerke M, Bjørnerud A. , et al. Monocyte chemo-attractant protein (MCP1) links microglia activation to predementia white matter (WM) tract integrity changes. Alzheimers Dement 2012; 8 (Suppl. 04) 269
    PubMedSearch in Google Scholar
  • 12 Blasko I, Lederer W, Oberbauer H. , et al. Measurement of thirteen biological markers in CSF of patients with Alzheimer's disease and other dementias. Dement Geriatr Cogn Disord 2006; 21 (01) 9-15
    CrossrefPubMedSearch in Google Scholar
  • 13 Michlmayr D, McKimmie CS, Pingen M. , et al. Defining the chemokine basis for leukocyte recruitment during viral encephalitis. J Virol 2014; 88 (17) 9553-9567
    CrossrefPubMedSearch in Google Scholar
  • 14 Uguccioni M, D'Apuzzo M, Loetscher M, Dewald B, Baggiolini M. Actions of the chemotactic cytokines MCP-1, MCP-2, MCP-3, RANTES, MIP-1 α and MIP-1 β on human monocytes. Eur J Immunol 1995; 25 (01) 64-68
    CrossrefPubMedSearch in Google Scholar
  • 15 Mack M, Cihak J, Simonis C. , et al. Expression and characterization of the chemokine receptors CCR2 and CCR5 in mice. J Immunol 2001; 166 (07) 4697-4704
    CrossrefPubMedSearch in Google Scholar
  • 16 Moon S, Wang Y, Dennehy P, Simonsen KA, Zhang J, Jiang B. Antigenemia, RNAemia, and innate immunity in children with acute rotavirus diarrhea. FEMS Immunol Med Microbiol 2012; 64 (03) 382-391
    CrossrefPubMedSearch in Google Scholar
  • 17 Crawford SE, Patel DG, Cheng E. , et al. Rotavirus viremia and extraintestinal viral infection in the neonatal rat model. J Virol 2006; 80 (10) 4820-4832
    CrossrefPubMedSearch in Google Scholar
  • 18 Dhillon NK, Williams R, Callen S, Zien C, Narayan O, Buch S. Roles of MCP-1 in development of HIV-dementia. Front Biosci 2008; 13: 3913-3918
    PubMedSearch in Google Scholar
  • 19 Park SY, Kwon JS, Kim JY. , et al. Severe fever with thrombocytopenia syndrome-associated encephalopathy/encephalitis. Clin Microbiol Infect 2018; 24 (04) 432.e1-432.e4
    CrossrefPubMedSearch in Google Scholar
  • 20 Kawashima H, Kashiwagi Y, Ioi H. , et al. Production of chemokines in respiratory syncytial virus infection with central nervous system manifestations. J Infect Chemother 2012; 18 (06) 827-831
    CrossrefPubMedSearch in Google Scholar
  • 21 Lee N, Wong CK, Chan PK. , et al. Acute encephalopathy associated with influenza A infection in adults. Emerg Infect Dis 2010; 16 (01) 139-142
    CrossrefPubMedSearch in Google Scholar
  • 22 Ball JM, Tian P, Zeng CQ, Morris AP, Estes MK. Age-dependent diarrhea induced by a rotaviral nonstructural glycoprotein. Science 1996; 272 (5258): 101-104
    CrossrefPubMedSearch in Google Scholar
  • 23 Didsbury A, Wang C, Verdon D, Sewell MA, McIntosh JD, Taylor JA. Rotavirus NSP4 is secreted from infected cells as an oligomeric lipoprotein and binds to glycosaminoglycans on the surface of non-infected cells. Virol J 2011; 8: 551
    CrossrefPubMedSearch in Google Scholar
  • 24 Bugarcic A, Taylor JA. Rotavirus nonstructural glycoprotein NSP4 is secreted from the apical surfaces of polarized epithelial cells. J Virol 2006; 80 (24) 12343-12349
    CrossrefPubMedSearch in Google Scholar
  • 25 Zhang M, Zeng CQ, Morris AP, Estes MK. A functional NSP4 enterotoxin peptide secreted from rotavirus-infected cells. J Virol 2000; 74 (24) 11663-11670
    CrossrefPubMedSearch in Google Scholar
  • 26 Tian P, Ball JM, Zeng CQ, Estes MK. The rotavirus nonstructural glycoprotein NSP4 possesses membrane destabilization activity. J Virol 1996; 70 (10) 6973-6981
    CrossrefPubMedSearch in Google Scholar
  • 27 Yeom JS, Kim YS, Jun JS. , et al. NSP4 antibody levels in rotavirus gastroenteritis patients with seizures. Eur J Paediatr Neurol 2017; 21 (02) 367-373
    CrossrefPubMedSearch in Google Scholar
  • 28 de Jager W, Bourcier K, Rijkers GT, Prakken BJ, Seyfert-Margolis V. Prerequisites for cytokine measurements in clinical trials with multiplex immunoassays. BMC Immunol 2009; 10: 52
    CrossrefPubMedSearch in Google Scholar
  • 29 Verboon-Maciolek MA, Groenendaal F, Hahn CD. , et al. Human parechovirus causes encephalitis with white matter injury in neonates. Ann Neurol 2008; 64 (03) 266-273
    CrossrefPubMedSearch in Google Scholar