RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000181.xml
J Neurol Surg B Skull Base 2019; 80(02): 214-224
DOI: 10.1055/s-0039-1677865
DOI: 10.1055/s-0039-1677865
Invited Review
Challenges of Hearing Rehabilitation after Radiation and Chemotherapy
Weitere Informationen
Publikationsverlauf
14. April 2018
14. Dezember 2018
Publikationsdatum:
04. Februar 2019 (online)
Abstract
Radiation and chemotherapy are frequently used in the treatment of head and neck malignancies. Ototoxicity is a common adverse effect of these treatment modalities. This article discusses the patterns of hearing loss following chemotherapy and radiation therapy. Specific issues related to hearing rehabilitation in oncological patients will also be covered, such as controversies regarding treatment of radiation-induced serous otitis media, risks of otologic surgery, and the use of osseointegrated hearing aids and cochlear implants.
-
References
- 1 Hilal-Dandan R, Brunton LL. Cytotoxic Agents. New York, NY: McGraw-Hill Education; 2016. . Available at: hemonc.mhmedical.com/content.aspx?aid=1127554849
- 2 Gidley PW, DeMonte F. Temporal bone malignancies. Neurosurg Clin N Am 2013; 24 (01) 97-110
- 3 Piel IJ, Meyer D, Perlia CP, Wolfe VI. Effects of cis-diamminedichloroplatinum (NSC-119875) on hearing function in man. Cancer Chemother Rep 1974; 58 (06) 871-875
- 4 Landier W. Ototoxicity and cancer therapy. Cancer 2016; 122 (11) 1647-1658
- 5 Bertolini P, Lassalle M, Mercier G. , et al. Platinum compound-related ototoxicity in children: long-term follow-up reveals continuous worsening of hearing loss. J Pediatr Hematol Oncol 2004; 26 (10) 649-655
- 6 Grewal S, Merchant T, Reymond R, McInerney M, Hodge C, Shearer P. Auditory late effects of childhood cancer therapy: a report from the Children's Oncology Group. Pediatrics 2010; 125 (04) e938-e950
- 7 Li Y, Womer RB, Silber JH. Predicting cisplatin ototoxicity in children: the influence of age and the cumulative dose. Eur J Cancer 2004; 40 (16) 2445-2451
- 8 Kamogashira T, Fujimoto C, Yamasoba T. Reactive oxygen species, apoptosis, and mitochondrial dysfunction in hearing loss. BioMed Res Int 2015; 2015: 617207
- 9 Hoistad DL, Ondrey FG, Mutlu C, Schachern PA, Paparella MM, Adams GL. Histopathology of human temporal bone after cis-platinum, radiation, or both. Otolaryngol Head Neck Surg 1998; 118 (06) 825-832
- 10 Breglio AM, Rusheen AE, Shide ED. , et al. Cisplatin is retained in the cochlea indefinitely following chemotherapy. Nat Commun 2017; 8 (01) 1654
- 11 Brock PR, Bellman SC, Yeomans EC, Pinkerton CR, Pritchard J. Cisplatin ototoxicity in children: a practical grading system. Med Pediatr Oncol 1991; 19 (04) 295-300
- 12 Schmidt CM, Bartholomäus E, Deuster D, Heinecke A, Dinnesen AG. The “Muenster classification” of high frequency hearing loss following cisplatin chemotherapy [in German]. HNO 2007; 55 (04) 299-306
- 13 Chang KW, Chinosornvatana N. Practical grading system for evaluating cisplatin ototoxicity in children. J Clin Oncol 2010; 28 (10) 1788-1795
- 14 Theunissen EA, Dreschler WA, Latenstein MN. , et al. A new grading system for ototoxicity in adults. Ann Otol Rhinol Laryngol 2014; 123 (10) 711-718
- 15 Sakamoto M, Kaga K, Kamio T. Extended high-frequency ototoxicity induced by the first administration of cisplatin. Otolaryngol Head Neck Surg 2000; 122 (06) 828-833
- 16 Reddel RR, Kefford RF, Grant JM, Coates AS, Fox RM, Tattersall MH. Ototoxicity in patients receiving cisplatin: importance of dose and method of drug administration. Cancer Treat Rep 1982; 66 (01) 19-23
- 17 Crabb SJ, Martin K, Abab J. , et al. COAST (cisplatin ototoxicity attenuated by aspirin trial): a phase II double-blind, randomised controlled trial to establish if aspirin reduces cisplatin induced hearing-loss. Eur J Cancer 2017; 87: 75-83
- 18 Landier W, Knight K, Wong FL. , et al. Ototoxicity in children with high-risk neuroblastoma: prevalence, risk factors, and concordance of grading scales--a report from the Children's Oncology Group. J Clin Oncol 2014; 32 (06) 527-534
- 19 Dalton DS, Cruickshanks KJ, Klein BE, Klein R, Wiley TL, Nondahl DM. The impact of hearing loss on quality of life in older adults. Gerontologist 2003; 43 (05) 661-668
- 20 Gurney JG, Tersak JM, Ness KK, Landier W, Matthay KK, Schmidt ML. ; Children's Oncology Group. Hearing loss, quality of life, and academic problems in long-term neuroblastoma survivors: a report from the Children's Oncology Group. Pediatrics 2007; 120 (05) e1229-e1236
- 21 Blazer DG, Domnitz S, Liverman CT. , eds. Hearing Health Care for Adults: Priorities for Improving Access and Affordability. Washington, DC: National Academies Press; 2016
- 22 Ishikawa E, Sugimoto H, Hatano M. , et al. Protective effects of sodium thiosulfate for cisplatin-mediated ototoxicity in patients with head and neck cancer. Acta Otolaryngol 2015; 135 (09) 919-924
- 23 Villani V, Zucchella C, Cristalli G. , et al. Vitamin E neuroprotection against cisplatin ototoxicity: preliminary results from a randomized, placebo-controlled trial. Head Neck 2016; 38 (Suppl. 01) E2118-E2121
- 24 Marshak T, Steiner M, Kaminer M, Levy L, Shupak A. Prevention of cisplatin-induced hearing loss by intratympanic dexamethasone: a randomized controlled study. Otolaryngol Head Neck Surg 2014; 150 (06) 983-990
- 25 Nader ME, Théorêt Y, Saliba I. The role of intratympanic lactate injection in the prevention of cisplatin-induced ototoxicity. Laryngoscope 2010; 120 (06) 1208-1213
- 26 Lavigne P, Lavigne F, Saliba I. Sustained inner ear steroid delivery via bioabsorbable stent: a tolerability and feasibility study on guinea pigs. Otolaryngol Head Neck Surg 2016; 155 (04) 649-653
- 27 Adelstein D, Gillison ML, Pfister DG. , et al. NCCN guidelines insights: head and neck cancers, version 2.2017. J Natl Compr Canc Netw 2017; 15 (06) 761-770
- 28 Trotti A. Toxicity in head and neck cancer: a review of trends and issues. Int J Radiat Oncol Biol Phys 2000; 47 (01) 1-12
- 29 Ondrey FG, Greig JR, Herscher L. Radiation dose to otologic structures during head and neck cancer radiation therapy. Laryngoscope 2000; 110 (2, Pt 1): 217-221
- 30 Lambert EM, Gunn GB, Gidley PW. Effects of radiation on the temporal bone in patients with head and neck cancer. Head Neck 2016; 38 (09) 1428-1435
- 31 Bhandare N, Antonelli PJ, Morris CG, Malayapa RS, Mendenhall WM. Ototoxicity after radiotherapy for head and neck tumors. Int J Radiat Oncol Biol Phys 2007; 67 (02) 469-479
- 32 Jereczek-Fossa BA, Zarowski A, Milani F, Orecchia R. Radiotherapy-induced ear toxicity. Cancer Treat Rev 2003; 29 (05) 417-430
- 33 Gyorkey J, Pollock FJ. Radiation necrosis of the ossicles. AMA Arch Otolaryngol 1960; 71: 793-796
- 34 Tang NL, Choy AT, John DG, van Hasselt CA. The otological status of patients with nasopharyngeal carcinoma after megavoltage radiotherapy. J Laryngol Otol 1992; 106 (12) 1055-1058
- 35 Low WK, Fong KW. Long-term post-irradiation middle ear effusion in nasopharyngeal carcinoma. Auris Nasus Larynx 1998; 25 (03) 319-321
- 36 Kew J, King AD, Leung SF. , et al. Middle ear effusions after radiotherapy: correlation with pre-radiotherapy nasopharyngeal tumor patterns. Am J Otol 2000; 21 (06) 782-785
- 37 Hsin CH, Chen TH, Liang KL, Tseng HC, Liu WS. Postirradiation otitis media with effusion in nasopharyngeal carcinoma patients treated by intensity-modulated radiotherapy. Laryngoscope 2013; 123 (09) 2148-2153
- 38 Liang KL, Su MC, Twu CW, Jiang RS, Lin JC, Shiao JY. Long-term result of management of otitis media with effusion in patients with post-irradiated nasopharyngeal carcinoma. Eur Arch Otorhinolaryngol 2011; 268 (02) 213-217
- 39 Hsin CH, Tseng HC, Lin HP, Chen TH. Post-irradiation otitis media, rhinosinusitis, and their interrelationship in nasopharyngeal carcinoma patients treated by IMRT. Eur Arch Otorhinolaryngol 2016; 273 (02) 471-477
- 40 Elwany S. Delayed ultrastructural radiation induced changes in the human mesotympanic middle ear mucosa. J Laryngol Otol 1985; 99 (04) 343-353
- 41 Panossian D, Jung TT, Weeks D. , et al. Effect of the radioprotector WR2721 on irradiation-induced injury to ciliated cells of eustachian tube. Ann Otol Rhinol Laryngol 1992; 101 (05) 395-402
- 42 Wang SZ, Wang WF, Zhang HY, Guo M, Hoffman MR, Jiang JJ. Analysis of anatomical factors controlling the morbidity of radiation-induced otitis media with effusion. Radiother Oncol 2007; 85 (03) 463-468
- 43 Walker GV, Ahmed S, Allen P. , et al. Radiation-induced middle ear and mastoid opacification in skull base tumors treated with radiotherapy. Int J Radiat Oncol Biol Phys 2011; 81 (05) e819-e823
- 44 Bass JK, Hua CH, Huang J. , et al. Hearing loss in patients who received cranial radiation therapy for childhood cancer. J Clin Oncol 2016; 34 (11) 1248-1255
- 45 Li JJ, Guo YK, Tang QL. , et al. Prospective study of sensorineural hearing loss following radiotherapy for nasopharyngeal carcinoma. J Laryngol Otol 2010; 124 (01) 32-36
- 46 Chi FH, Young YH. Inner ear deficits in irradiated nasopharyngeal carcinoma survivors. Laryngoscope 2015; 125 (11) 2565-2571
- 47 Scobioala S, Parfitt R, Matulat P. , et al. Impact of radiation technique, radiation fraction dose, and total cisplatin dose on hearing : Retrospective analysis of 29 medulloblastoma patients. Strahlenther Onkol 2017; 193 (11) 910-920
- 48 Wang LF, Kuo WR, Ho KY, Lee KW, Lin CS. A long-term study on hearing status in patients with nasopharyngeal carcinoma after radiotherapy. Otol Neurotol 2004; 25 (02) 168-173
- 49 Theunissen EA, Bosma SC, Zuur CL. , et al. Sensorineural hearing loss in patients with head and neck cancer after chemoradiotherapy and radiotherapy: a systematic review of the literature. Head Neck 2015; 37 (02) 281-292
- 50 Mujica-Mota M, Waissbluth S, Daniel SJ. Characteristics of radiation-induced sensorineural hearing loss in head and neck cancer: a systematic review. Head Neck 2013; 35 (11) 1662-1668
- 51 Herrmann F, Dörr W, Müller R, Herrmann T. A prospective study on radiation-induced changes in hearing function. Int J Radiat Oncol Biol Phys 2006; 65 (05) 1338-1344
- 52 Hitchcock YJ, Tward JD, Szabo A, Bentz BG, Shrieve DC. Relative contributions of radiation and cisplatin-based chemotherapy to sensorineural hearing loss in head-and-neck cancer patients. Int J Radiat Oncol Biol Phys 2009; 73 (03) 779-788
- 53 Pan CC, Eisbruch A, Lee JS, Snorrason RM, Ten Haken RK, Kileny PR. Prospective study of inner ear radiation dose and hearing loss in head-and-neck cancer patients. Int J Radiat Oncol Biol Phys 2005; 61 (05) 1393-1402
- 54 Bohne BA, Marks JE, Glasgow GP. Delayed effects of ionizing radiation on the ear. Laryngoscope 1985; 95 (7, Pt 1): 818-828
- 55 Low WK, Tan MG, Chua AW, Sun L, Wang DY. 12th Yahya Cohen Memorial Lecture: the cellular and molecular basis of radiation-induced sensori-neural hearing loss. Ann Acad Med Singapore 2009; 38 (01) 91-94
- 56 Leach W. Irradiation of the ear. J Laryngol Otol 1965; 79 (10) 870-880
- 57 Schuknecht HF, Karmody CS. Radionecrosis of the temporal bone. Laryngoscope 1966; 76 (08) 1416-1428
- 58 Asenov DR, Kaga K, Tsuzuku T. Changes in the audiograms of a nasopharyngeal cancer patient during the course of treatment: a temporal bone histopathological study. Acta Otolaryngol 2007; 127 (10) 1105-1110
- 59 Low WK, Tan MG, Sun L, Chua AW, Goh LK, Wang DY. Dose-dependant radiation-induced apoptosis in a cochlear cell-line. Apoptosis 2006; 11 (12) 2127-2136
- 60 Rybak LP, Whitworth CA. Ototoxicity: therapeutic opportunities. Drug Discov Today 2005; 10 (19) 1313-1321
- 61 Shah JO, Herrera SJ, Roberts DB, Gunn GB, Gidley PW. Complications of tympanostomy tubes in head and neck cancer patients. Am J Otolaryngol 2016; 37 (04) 356-361
- 62 Xu YD, Ou YK, Zheng YQ, Chen Y, Ji SF. The treatment for postirradiation otitis media with effusion: a study of three methods. Laryngoscope 2008; 118 (11) 2040-2043
- 63 Ho WK, Wei WI, Kwong DL. , et al. Randomized evaluation of the audiologic outcome of ventilation tube insertion for middle ear effusion in patients with nasopharyngeal carcinoma. J Otolaryngol 2002; 31 (05) 287-293
- 64 Chen CY, Young YH, Hsu WC, Hsu MM. Failure of grommet insertion in post-irradiation otitis media with effusion. Ann Otol Rhinol Laryngol 2001; 110 (08) 746-748
- 65 Young YH, Lu YC. Mechanism of hearing loss in irradiated ears: a long-term longitudinal study. Ann Otol Rhinol Laryngol 2001; 110 (10) 904-906
- 66 Morton RP, Woollons AC, McIvor NP. Nasopharyngeal carcinoma and middle ear effusion: natural history and the effect of ventilation tubes. Clin Otolaryngol Allied Sci 1994; 19 (06) 529-531
- 67 Soo G, Tong MC, Tsang WS. , et al. The BAHA hearing system for hearing-impaired postirradiated nasopharyngeal cancer patients: a new indication. Otol Neurotol 2009; 30 (04) 496-501
- 68 Kuo CL, Wang MC, Chu CH, Shiao AS. New therapeutic strategy for treating otitis media with effusion in postirradiated nasopharyngeal carcinoma patients. J Chin Med Assoc 2012; 75 (07) 329-334
- 69 Schwarz Y, Manogaran M, Daniel SJ. Ventilation tubes in middle ear effusion post-nasopharyngeal carcinoma radiation: To insert or not?. Laryngoscope 2016; 126 (12) 2649-2651
- 70 Silvola J, Kivekäs I, Poe DS. Balloon dilation of the cartilaginous portion of the eustachian tube. Otolaryngol Head Neck Surg 2014; 151 (01) 125-130
- 71 Kapadia M, Tarabichi M. Feasibility and safety of transtympanic balloon dilatation of eustachian tube. Otol Neurotol 2018; 39 (09) e825-e830
- 72 Huisman JML, Verdam FJ, Stegeman I, de Ru JA. Treatment of eustachian tube dysfunction with balloon dilation: a systematic review. Laryngoscope 2018; 128 (01) 237-247
- 73 O'Neill JV, Katz AH, Skolnik EM. Otologic complications of radiation therapy. Otolaryngol Head Neck Surg (1979) 1979; 87 (03) 359-363
- 74 Stone HB, Coleman CN, Anscher MS, McBride WH. Effects of radiation on normal tissue: consequences and mechanisms. Lancet Oncol 2003; 4 (09) 529-536
- 75 Bennett M, Kaylie D, Warren F, Jackson CG. Chronic ear surgery in irradiated temporal bones. Laryngoscope 2007; 117 (07) 1240-1244
- 76 Hsu YC, Su CY. Tympanoplasty for chronic otitis media in post-irradiated nasopharyngeal carcinoma patients. Ann Otol Rhinol Laryngol 2006; 115 (05) 330-333
- 77 Yuen PW, Wei WI. Tympanomastoidectomy for chronic suppurative otitis media of irradiated ears of nasopharyngeal carcinoma patients. J Otolaryngol 1994; 23 (04) 302-304
- 78 Jegoux F, Malard O, Goyenvalle E, Aguado E, Daculsi G. Radiation effects on bone healing and reconstruction: interpretation of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109 (02) 173-184
- 79 Ihde S, Kopp S, Gundlach K, Konstantinović VS. Effects of radiation therapy on craniofacial and dental implants: a review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 107 (01) 56-65
- 80 Granström G. Osseointegration in irradiated cancer patients: an analysis with respect to implant failures. J Oral Maxillofac Surg 2005; 63 (05) 579-585
- 81 Abu-Serriah MM, McGowan DA, Moos KF, Bagg J. Extra-oral craniofacial endosseous implants and radiotherapy. Int J Oral Maxillofac Surg 2003; 32 (06) 585-592
- 82 Nader ME, Beadle BM, Roberts DB, Gidley PW. Outcomes and complications of osseointegrated hearing aids in irradiated temporal bones. Laryngoscope 2016; 126 (05) 1187-1192
- 83 Wilkie MD, Lightbody KA, Salamat AA, Chakravarthy KM, Luff DA, Temple RH. Stability and survival of bone-anchored hearing aid implant systems in post-irradiated patients. Eur Arch Otorhinolaryngol 2015; 272 (06) 1371-1376
- 84 Kiringoda R, Lustig LR. A meta-analysis of the complications associated with osseointegrated hearing aids. Otol Neurotol 2013; 34 (05) 790-794
- 85 Beumer III J, Roumanas E, Nishimura R. Advances in osseointegrated implants for dental and facial rehabilitation following major head and neck surgery. Semin Surg Oncol 1995; 11 (03) 200-207
- 86 Al-Mahalawy H, Marei HF, Abuohashish H, Alhawaj H, Alrefaee M, Al-Jandan B. Effects of cisplatin chemotherapy on the osseointegration of titanium implants. J Craniomaxillofac Surg 2016; 44 (04) 337-346
- 87 Wazen JJ, Young DL, Farrugia MC. , et al. Successes and complications of the Baha system. Otol Neurotol 2008; 29 (08) 1115-1119
- 88 Holgers KM, Tjellström A, Bjursten LM, Erlandsson BE. Soft tissue reactions around percutaneous implants: a clinical study of soft tissue conditions around skin-penetrating titanium implants for bone-anchored hearing aids. Am J Otol 1988; 9 (01) 56-59
- 89 Chen SY, Mancuso D, Lalwani AK. Skin necrosis after implantation with the BAHA attract: a case report and review of the literature. Otol Neurotol 2017; 38 (03) 364-367
- 90 Greene JS, Giddings NA, Jacobson JT. Effect of irradiation on guinea pig ABR thresholds. Otolaryngol Head Neck Surg 1992; 107 (6, Pt 1): 763-768
- 91 Low WK, Burgess R, Fong KW, Wang DY. Effect of radiotherapy on retro-cochlear auditory pathways. Laryngoscope 2005; 115 (10) 1823-1826
- 92 Soh JM, D'Souza VD, Sarepaka GK, Ng WN, Ong CS, Low WK. cochlear implant outcomes: a comparison between irradiated and non-irradiated ears. Clin Exp Otorhinolaryngol 2012; 5 (Suppl. 01) S93-S98
- 93 Roland Jr JT, Cosetti M, Liebman T, Waltzman S, Allen JC. Cochlear implantation following treatment for medulloblastoma. Laryngoscope 2010; 120 (01) 139-143
- 94 Low WK, Gopal K, Goh LK, Fong KW. Cochlear implantation in postirradiated ears: outcomes and challenges. Laryngoscope 2006; 116 (07) 1258-1262
- 95 Yue V, Leung EK, Wong TK, Tong MC, Van Hasselt CA. Cochlear implantation for post-irradiation deafness. Cochlear Implants Int 2004; 5 (Suppl. 01) 165-168
- 96 Adunka OF, Buchman CA. Cochlear implantation in the irradiated temporal bone. J Laryngol Otol 2007; 121 (01) 83-86
- 97 Chua DY, Tan HK. Successful rehabilitation with cochlear implant in post-irradiation induced hearing loss in nasopharyngeal carcinoma patient. Ann Acad Med Singapore 2007; 36 (01) 74-77
- 98 Biggs ND, Ramsden RT. Cochlear implantation in a previously irradiated temporal bone--a case report. Cochlear Implants Int 2001; 2 (02) 129-134
- 99 Formanek M, Czerny C, Gstoettner W, Kornfehl J. Cochlear implantation as a successful rehabilitation for radiation-induced deafness. Eur Arch Otorhinolaryngol 1998; 255 (04) 175-178
- 100 Carlson ML, Neff BA, Link MJ. , et al. Magnetic resonance imaging with cochlear implant magnet in place: safety and imaging quality. Otol Neurotol 2015; 36 (06) 965-971
- 101 Walton J, Donnelly NP, Tam YC. , et al. MRI without magnet removal in neurofibromatosis type 2 patients with cochlear and auditory brainstem implants. Otol Neurotol 2014; 35 (05) 821-825
- 102 Gubbels SP, McMenomey SO. Safety study of the cochlear nucleus 24 device with internal magnet in the 1.5 tesla magnetic resonance imaging scanner. Laryngoscope 2006; 116 (06) 865-871
- 103 Guevara N, Gérard A, Dupré J. , et al. Influence of ionizing radiation on two generations of cochlear implants. BioMed Res Int 2015; 2015: 609607
- 104 Klenzner T, Knapp F, Röhner F. , et al. Influence of ionizing radiation on nucleus 24 cochlear implants. Otol Neurotol 2005; 26 (04) 661-667
- 105 Markiewicz M, Giebel S, Wyleioł I. , et al. Allogeneic bone marrow transplantation with total body irradiation-based conditioning in acute lymphoblastic leukemia patient with Cochlear implant. Ann Transplant 2006; 11 (02) 21-22 , discussion 32–43
- 106 Reddy K, Cook B, Shaw C. , et al. Intact performance of a cochlear implant following radiotherapy in a child with acute lymphoblastic leukemia. Pract Radiat Oncol 2012; 2 (03) 233-236
- 107 Ryu NG, Moon IJ, Chang YS. , et al. Cochlear implantation for profound hearing loss after multimodal treatment for neuroblastoma in children. Clin Exp Otorhinolaryngol 2015; 8 (04) 329-334
- 108 Harris MS, Gilbert JL, Lormore KA, Musunuru SA, Fritsch MH. Cisplatin ototoxicity affecting cochlear implant benefit. Otol Neurotol 2011; 32 (06) 969-972