Interventional Oncology in Immuno-Oncology Part 2: Transcatheter Therapies

Meaghan Dendy Case; Ryan Slovak; Junaid Raja; Hyun S. Kim

doi:10.1055/s-0039-1679936

Digestive Disease Interventions, Table of Contents

Digestive Disease Interventions 2019; 03(02): 155-162
DOI: 10.1055/s-0039-1679936

Review Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Interventional Oncology in Immuno-Oncology Part 2: Transcatheter Therapies

Meaghan Dendy Case

¹Division of Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut

,

Ryan Slovak

¹Division of Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut

²University of Connecticut School of Medicine, Farmington, Connecticut

,

Junaid Raja

¹Division of Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut

,

Hyun S. Kim

¹Division of Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut

³Division of Medical Oncology, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut

⁴Yale Cancer Center, Yale School of Medicine, New Haven, New Haven, Connecticut

› Author Affiliations

Abstract

The use of transcatheter embolization in its various forms in interventional oncology has altered the treatment paradigms for multiple types of cancer. Though direct investigation of the immunologic effects of transcatheter treatments has been limited, research on radiation therapy can be extrapolated to better understand the potential effects of radioembolization and studies on the immune response to chemotherapy can potentially explain the immune response to hepatic artery infusion and chemoembolization. Utilization of newer systemic immunotherapies in combination with various transcatheter therapies also presents the potential for improving outcomes for multiple malignancies. This review will discuss the role of transcatheter therapies in stimulating an immune response as well as the potential these techniques have to enhance the effects of systemic immunotherapy.

Keywords

transcatheter - immuno-oncology - abscopal

Full Text

References

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