Endoscopy 2019; 51(04): S8
DOI: 10.1055/s-0039-1681192
ESGE Days 2019 oral presentations
Friday, April 5, 2019 08:30 – 10:30: Capsule 1 Club B
Georg Thieme Verlag KG Stuttgart · New York

IMPACT OF PILLCAM CROHN'S CAPSULE ON DIAGNOSTIC YIELD AND CLINICAL MANAGEMENT: RESULTS OF THE FIRST MULTICENTER, OBSERVATIONAL STUDY

GE Tontini
1   Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
,
F Rizzello
2   IBD Unit, Department of Medical and Surgical Sciences (DIMEC), Policlinico S. Orsola-Malpighi, University of Bologna, Bologna, Italy
,
M Topa
1   Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
,
F Cavallaro
3   Gastroenterology and Digestive Endoscopy Unit, IRCCS Policlinico San Donato, San Donato Milanese (Milan), Italy
,
G Bonitta
3   Gastroenterology and Digestive Endoscopy Unit, IRCCS Policlinico San Donato, San Donato Milanese (Milan), Italy
,
D Gelli
2   IBD Unit, Department of Medical and Surgical Sciences (DIMEC), Policlinico S. Orsola-Malpighi, University of Bologna, Bologna, Italy
,
L Pastorelli
3   Gastroenterology and Digestive Endoscopy Unit, IRCCS Policlinico San Donato, San Donato Milanese (Milan), Italy
4   Department of Biomedical Sciences for Health, University of Milan, Milan, Italy
,
M Salice
2   IBD Unit, Department of Medical and Surgical Sciences (DIMEC), Policlinico S. Orsola-Malpighi, University of Bologna, Bologna, Italy
,
M Vecchi
1   Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
5   Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
,
P Gionchetti
2   IBD Unit, Department of Medical and Surgical Sciences (DIMEC), Policlinico S. Orsola-Malpighi, University of Bologna, Bologna, Italy
,
C Calabrese
2   IBD Unit, Department of Medical and Surgical Sciences (DIMEC), Policlinico S. Orsola-Malpighi, University of Bologna, Bologna, Italy
› Author Affiliations
Further Information

Publication History

Publication Date:
18 March 2019 (online)

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Aims:

A capsule endoscopy (CE) system tailored for Crohn's disease (CD) patients has been recently developed. This new device features two advanced optics allowing a 344 °-view between both capsule heads and a prolonged operative time, to provide the direct visualization of the entire digestive tract. The present study has evaluated, for the first time, the performance of the PillCam Crohn's System in a multi-center real-life setting.

Methods:

Consecutive patients with suspected or established CD were included between June 2017 and June 2018. Technical and clinical data, including the Lewis score and capsule impact on clinical management, were collected, thereby evaluating the added value of the 344 ° panoramic-view over the standard 172 °-view.

Results:

Among 41 patients (16 men; aged 43 ± 20 years), 73% underwent CE for suspected CD and 27% for established CD, with a mean time lapse of 12 years from diagnosis. The rate of complete enteroscopy was 90%. No technical failure or retention occurred. CE detected relevant lesions in 56.1% of patients, a Lewis score ≥135 in 51.4%, and had an impact on clinical management for 48.8% of patients. Compared to the standard 172 °-view, the panoramic 344 °-view revealed a greater number of patients with a relevant lesion (56.1% vs. 39.0%; P = 0.023), resulting in higher Lewis score (222.8 vs. 185.7; P = 0.031), and improved clinical management (48.8% vs. 31.7%, P = 0.023).

Conclusions:

The panoramic 344 °-view improves both CE accuracy and the resulting clinical management of CD. This system should be regarded as a new standard for both small- bowel diagnosis and inflammatory bowel diseases monitoring.