Endoscopy 2019; 51(04): S136
DOI: 10.1055/s-0039-1681571
ESGE Days 2019 ePoster podium presentations
Friday, April 5, 2019 13:00 – 13:30: Bowel cleansing 1 ePoster Podium 1
Georg Thieme Verlag KG Stuttgart · New York

ORAL SULFATE SOLUTION IN OBESE PATIENTS AS PREPARATION FOR COLONOSCOPY: A PROSPECTIVE, MULTICENTER, NONINFERIORITY TRIAL

, , Daegu-Gyeongbuk Gastrointestinal Study Group (DGSG)
HS Lee
1   Gastroenterology and Hepatology/Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea, Republic of
,
EY Kim
2   Catholic University of Daegu School of Medicine, Daegu, Korea, Republic of
,
ES Kim
3   School of Medicine, Kyungpook National University, Daegu, Korea, Republic of
,
SK Kim
3   School of Medicine, Kyungpook National University, Daegu, Korea, Republic of
,
YJ Lee
4   Keimyung University School of Medicine, Daegu, Korea, Republic of
,
HJ Lee
4   Keimyung University School of Medicine, Daegu, Korea, Republic of
,
BI Jang
5   Yeungnam University College of Medicine, Daegu, Korea, Republic of
,
KO Kim
6   Daegu Fatima Hospital, Daegu, Korea, Republic of
,
CH Yang
7   Dongguk University School of Medicine, Gyeongju, Korea, Republic of
,
YS Hwan
7   Dongguk University School of Medicine, Gyeongju, Korea, Republic of
,
YG Kim
8   Soonchunhyang University College of Medicine, Gumi, Korea, Republic of
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Publikationsverlauf

Publikationsdatum:
18. März 2019 (online)

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Aims:

Obesity might be related to inadequate bowel preparation with conventional lavage solution. A new formulation of oral sulfate solution (OSS, Suclear) showed effective bowel preparation compared with a standard 4L polyethylene glycol regimen in general population. However, there is no study on bowel preparation with OSS in obese patients. We investigated whether OSS is effective in obese patients as bowel preparation for colonoscopy.

Methods:

We compared the efficacy of OSS in obese patients with those in non-obese patients as bowel preparation for colonoscopy. This was a prospective, multicenter, single-blind, noninferiority study of adult outpatients undergoing routine elective colonoscopy. Body mass index (BMI) was categorized as obese (BMI 25 or more 25 kg/m2) or non-obese (less than 25 kg/m2). Both obese and non-obese patients respectively received OSS given in equally divided doses the evening before and the morning of colonoscopy. Adequate bowel preparation was defined as the Boston bowel preparation scale score ≥6. The noninferiority margin for the difference in adequate bowel preparation rate was defined as -15%.

Results:

Colonoscopic examinations were performed in 96 obese and 98 non-obese patients. Adequate bowel preparation rate was 88.5% in obese patients and 94.9% in non-obese patients. With an absolute difference -6.4%, 95% CI -0.142 to 0.015, bowel preparation in obese patients was noninferior to that in non-obese patients.

Conclusions:

Bowel preparation with OSS for colonoscopy in obese patients is noninferior compared to that in non-obese patients.