Endoscopy 2019; 51(04): S250
DOI: 10.1055/s-0039-1681925
ESGE Days 2019 ePosters
Friday, April 5, 2019 09:00 – 17:00: Stomach and small intestine ePosters
Georg Thieme Verlag KG Stuttgart · New York

ANALYSIS OF GASTRIC AND DUODENAL BIOPSY RESULTS IN PATIENTS PRESENTING WITH DYSPEPSIA: A CROSS SECTIONAL STUDY IN A TERTIARY HOSPITAL CENTER IN LEBANON

S Farhat
1   Saint George Hospital University Medical Center, Department of Gastroenterology, Beirut, Lebanon
,
M Hussein Kamareddine
2   University of Balamand, Department of Medicine and Medical Sciences, Kalhat, Lebanon
,
N Bou-Ayash
2   University of Balamand, Department of Medicine and Medical Sciences, Kalhat, Lebanon
,
Y Ghosn
2   University of Balamand, Department of Medicine and Medical Sciences, Kalhat, Lebanon
,
G Jabbour
1   Saint George Hospital University Medical Center, Department of Gastroenterology, Beirut, Lebanon
,
G Cortas
3   Saint George Hospital University Medical Center, Gastroenterology, Beirut, Lebanon
,
S Khoury
3   Saint George Hospital University Medical Center, Gastroenterology, Beirut, Lebanon
,
K Bedran
4   Saint George Hospital University Medical Center, Gastroenterology, Achrafieh, Lebanon
› Institutsangaben
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Publikationsverlauf

Publikationsdatum:
18. März 2019 (online)

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Aims:

Around a half a century ago, Peleyo Correa described a “Model for Gastric Cancer Development” referred to as Correa's cascade. Today, roughly half of the world's population are infected with Helicobacter pylori (H. pylori), the main cause of chronic gastritis. While the reversibility of Correa's cascade is still debatable, there is insufficient data on the specific stage of the cascade during which H. pylori is detected and treated and its effect on prognosis.

The Objectives of this study is to determine the prevalence of gastritis and H. pylori in patients presenting with dyspepsia, identify the prevalence of various pre-cancerous and cancerous gastric lesions, identify the stage of H. pylori detection in relation to Correa's cascade, determine the prevalence of duodenal pathology in patients presenting with dyspepsia, and investigate a possible relationship between H. pylori and celiac disease.

Methods:

An analytical cross sectional study was conducted at a Lebanese tertiary hospital center. 1428 patients presenting with dyspepsia underwent gastroscopy and duodenoscopy with biopsies. Variables include age, sex, presence/absence of H. pylori infection, and histopathological analysis of gastric and duodenal biopsies. Data was analyzed using SPSS v24.

Results:

Being above 40 years of age was associated with an increased likelihood of exhibiting abnormal gastric biopsy results. Gastritis and metaplasia are being detected more frequently than glandular atrophy (p < 0.001) with Gastritis being present the most (p < 0.001). No relationship was found between H. pylori and any of the duodenal biopsy results. Similarly, there was no relationship between gastric biopsy results and duodenal biopsy results.

Conclusions:

The burden of H. pylori infection in patients with dyspepsia was high. H. pylori was detected at various pre-cancerous lesions with varying significance. The prevalence of duodenal adenocarcinoma in dyspeptic patients is unexpectedly high. No association between gastric and duodenal pathologies was found.