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Semin Respir Crit Care Med 2019; 40(01): 129-136
DOI: 10.1055/s-0039-1683997
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Clinical Strategies to Prevent Acute Respiratory Distress Syndrome

Yewande E. Odeyemi
1   Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota
,
Svetlana Herasevich
1   Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota
,
Michelle N. Gong
2   Division of Critical Care Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York
,
Ognjen O. Gajic
1   Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota
› Author Affiliations
Further Information

Publication History

Publication Date:
06 May 2019 (online)

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Abstract

Acute respiratory distress syndrome (ARDS) remains an important clinical entity in the intensive care unit with a significant impact on morbidity and mortality. Effective therapeutic interventions are limited; thus current research focus has shifted from treatment to the prevention of this pulmonary syndrome. In recent decades, a decrease in the incidence of ARDS has been observed and this reduction is largely due to preventive strategies including safe lung ventilation practices, avoidance of iatrogenic exposures, and improvement in care of predisposing conditions such as sepsis and pneumonia. Early identification of at-risk patients, prompt treatment of predisposing conditions, and adoption of evidence-based best practice including restrictive transfusion strategies, conservative fluid management, avoidance of large tidal volume ventilation, and aspiration precaution practices are key preventive strategies with demonstrated benefits. There are currently no effective pharmacological preventive strategies for ARDS.

Keywords

acute respiratory distress syndrome - acute lung injury - prevention

Authors' Contribution

Yewande O, Svetlana H, Michelle G, and Ognjen G contributed to writing of the article, provided intellectual contributions to the content, and made critical revisions; all authors reviewed and approved the final version of the article.


 

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