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CC BY-NC-ND 4.0 · Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery 2019; 38(02): 128-136
DOI: 10.1055/s-0039-1685150
Case Report | Relato de Caso
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Oligodendroglioma with Sarcomatous Transformation: Case Report and Literature Review

Oligodendroglioma com transformação sarcomatosa: Caso clínico e revisão da literatura
Gonçalo Cerdeira Figueiredo 
1   Department of Neurosurgery, Centro Hospitalar do Porto, Porto, Portugal
,
Célia Maria Pinheiro
1   Department of Neurosurgery, Centro Hospitalar do Porto, Porto, Portugal
,
Alfredo Luís Calheiros
1   Department of Neurosurgery, Centro Hospitalar do Porto, Porto, Portugal
› Author Affiliations
Further Information

Publication History

23 October 2018

19 February 2019

Publication Date:
18 April 2019 (online)

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Abstract

Oligodendrogliomas are infiltrative tumors of the central nervous system considered to be morphologically stable and to offer a better prognosis. Here, we describe the case of a 36-year-old man with an initial diagnosis of oligodendroglioma, World Health Organization (WHO) grade II, who presented transformation to a sarcomatous form, while maintaining the oligodendroglial component as well as the genetic characteristics of the initial tumor without having undergone any complementary treatments previously. Despite the favorable genetic characteristics, the tumor presented poor response to complementary treatments, and rapid progression, including spinal metastasis.

Resumo

Oligodendrogliomas são tumores infiltrativos do sistema nervoso central considerados morfologicamente estáveis e com melhor prognóstico. Aqui, descrevemos o caso de um homem de 36 anos com diagnóstico inicial de oligodendroglioma grau II OMS, que apresentou transformação para uma forma sarcomatosa, mantendo as características genéticas do tumor inicial, sem ter sido submetido a tratamento complementar. Apesar das características genéticas favoráveis, o tumor apresentou má resposta aos tratamentos e progressão rápida, incluindo com metastização raquidiana.

Keywords

oligodendroglioma - oligosarcoma - co-deletion 1p/19q - spinal metastasis

Palavras-chave

oligodendroglioma - oligossarcoma - co-deleção 1p/19q - metástases raquidianas
 

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