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CC BY-NC-ND 4.0 · Journal of Morphological Sciences 2019; 36(02): 057-062
DOI: 10.1055/s-0039-1685456
Original Article
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Human Mandible Prenatal Morphogenesis

Sergey Lvovich Kabak
1   Human Morphology Department, Belarusian State Medical University, Minsk, Belarus
,
Natalia Victorovna Zhuravleva
1   Human Morphology Department, Belarusian State Medical University, Minsk, Belarus
,
Yuliya Michailovna Melnichenko
1   Human Morphology Department, Belarusian State Medical University, Minsk, Belarus
› Author Affiliations Funding The present study had no sponsorship.
Further Information

Publication History

12 August 2018

15 February 2019

Publication Date:
24 April 2019 (online)

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Abstract

Introduction This study was performed with the aim of detecting the interaction between cartilaginous and bone tissues in the process of mandible morphogenesis in human embryos.

Material and Methods Whole-mount skeletal preparations, stained with Alcian blue and Alizarin red, as well as serial histological sections impregnated with silver and stained with hematoxylin and eosin were studied. A total of 48 human embryos/fetuses from 5 to 29 weeks of age were used.

Results In the mandible anlage, in addition to the woven bone, cartilaginous and chondroid tissues are present. Cartilaginous tissue islets are localized at the tip of the condylar and coronoid processes and also in the region of the mandibular symphysis. The chondroid tissue is incorporated into the bone in the region of the mandibular symphysis, along the edge of the coronoid process, and also in the alveolar part of the mandible.

Conclusion Meckel’s cartilage participates in the formation of the mandibular body, and its remains persist in the area of the mandibular symphysis until the second half of the prenatal development.

Keywords

mandible - human development - Meckel’s cartilage - chondroid tissue - condylar cartilage
 

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