Semin Respir Crit Care Med 2019; 40(01): 137-144
DOI: 10.1055/s-0039-1685463
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Acute Respiratory Distress Syndrome: Cost (Early and Long-Term)

Thomas Bice
1   Division of Pulmonary and Critical Care Medicine, University of North Carolina Medical Center, Chapel Hill, North Carolina
,
Shannon S. Carson
1   Division of Pulmonary and Critical Care Medicine, University of North Carolina Medical Center, Chapel Hill, North Carolina
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
06. Mai 2019 (online)

Abstract

Costs of care in the intensive care unit are a frequent area of concern in our current health care system. Utilization of critical care services in the United States, particularly near the end of life, has been steadily increasing and will continue to do so. Acute respiratory distress syndrome (ARDS) is a common and important complication of critical illness. Patients with ARDS frequently experience prolonged hospitalizations and consume significant health care resources. Many patients are discharged with functional limitations and require significant postdischarge services. These patients have a high susceptibility to new complications which require significant additional health care resources. There is a slowly growing literature on the cost-effectiveness of the treatment of ARDS; despite its high costs, treatment remains a cost-effective intervention by most societal standards. However, when ARDS leads to prolonged mechanical ventilation, treatment may become less cost-effective. In addition, the provision of extracorporeal life support adds another layer of complexity to these cases. Small reductions in intensive care unit length of stay may benefit patients, but they do not lead to significant reductions in overall hospital costs. Early discharge to postacute care facilities can reduce hospital costs but is unlikely to significantly decrease costs for an entire episode of illness. Improved effectiveness of communication between clinicians and patients or their surrogates could help avoid costly interventions with poor expected outcomes. However, the most significant cost-saving interventions are early recognition and treatment of conditions to potentially prevent the development of this serious complication.

 
  • References

  • 1 Halpern NA, Pastores SM. Critical care medicine in the United States 2000–2005: an analysis of bed numbers, occupancy rates, payer mix, and costs. Crit Care Med 2010; 38 (01) 65-71
  • 2 Wunsch H, Linde-Zwirble WT, Angus DC, Hartman ME, Milbrandt EB, Kahn JM. The epidemiology of mechanical ventilation use in the United States. Crit Care Med 2010; 38 (10) 1947-1953
  • 3 Cooper LM, Linde-Zwirble WT. Medicare intensive care unit use: analysis of incidence, cost, and payment. Crit Care Med 2004; 32 (11) 2247-2253
  • 4 Dasta JF, McLaughlin TP, Mody SH, Piech CT. Daily cost of an intensive care unit day: the contribution of mechanical ventilation. Crit Care Med 2005; 33 (06) 1266-1271
  • 5 Kramer AA, Dasta JF, Kane-Gill SL. The impact of mortality on total costs within the ICU. Crit Care Med 2017; 45 (09) 1457-1463
  • 6 Kahn JM, Rubenfeld GD, Rohrbach J, Fuchs BD. Cost savings attributable to reductions in intensive care unit length of stay for mechanically ventilated patients. Med Care 2008; 46 (12) 1226-1233
  • 7 Mudumbai SC, Barr J, Scott J. , et al. Invasive mechanical ventilation in California over 2000–2009: implications for emergency medicine. West J Emerg Med 2015; 16 (05) 696-706
  • 8 Wunsch H, Wagner J, Herlim M, Chong DH, Kramer AA, Halpern SD. ICU occupancy and mechanical ventilator use in the United States. Crit Care Med 2013; 41 (12) 2712-2719
  • 9 Jegers M, Edbrooke DL, Hibbert CL, Chalfin DB, Burchardi H. Definitions and methods of cost assessment: an intensivist's guide. ESICM section on health research and outcome working group on cost effectiveness. Intensive Care Med 2002; 28 (06) 680-685
  • 10 Sznajder M, Aegerter P, Launois R, Merliere Y, Guidet B. , CubRea. A cost-effectiveness analysis of stays in intensive care units. Intensive Care Med 2001; 27 (01) 146-153
  • 11 Cooke CR, Kahn JM, Watkins TR, Hudson LD, Rubenfeld GD. Cost-effectiveness of implementing low-tidal volume ventilation in patients with acute lung injury. Chest 2009; 136 (01) 79-88
  • 12 Cox CE, Carson SS, Govert JA, Chelluri L, Sanders GD. An economic evaluation of prolonged mechanical ventilation. Crit Care Med 2007; 35 (08) 1918-1927
  • 13 Linko R, Suojaranta-Ylinen R, Karlsson S. , et al. One-year mortality, quality of life and predicted life-time cost-utility in critically ill patients with acute respiratory failure. Crit Care 2010; 14 (02) R60
  • 14 Hamel MB, Phillips RS, Davis RB. , et al. Outcomes and cost-effectiveness of ventilator support and aggressive care for patients with acute respiratory failure due to pneumonia or acute respiratory distress syndrome. Am J Med 2000; 109 (08) 614-620
  • 15 Carson SS, Kahn JM, Hough CL. , et al; ProVent Investigators. A multicenter mortality prediction model for patients receiving prolonged mechanical ventilation. Crit Care Med 2012; 40 (04) 1171-1176
  • 16 Cox CE, Martinu T, Sathy SJ. , et al. Expectations and outcomes of prolonged mechanical ventilation. Crit Care Med 2009; 37 (11) 2888-2894 , quiz 2904
  • 17 Carson SS. Outcomes of prolonged mechanical ventilation. Curr Opin Crit Care 2006; 12 (05) 405-411
  • 18 Cox CE, Carson SS, Lindquist JH. , et al. Differences in one-year health outcomes and resource utilization by definition of prolonged mechanical ventilation: a prospective cohort study. Crit Care 2007; 11 (01) R9
  • 19 Zilberberg MD, Shorr AF. Prolonged acute mechanical ventilation and hospital bed utilization in 2020 in the United States: implications for budgets, plant and personnel planning. BMC Health Serv Res 2008; 8 (01) 242
  • 20 Peek GJ, Mugford M, Tiruvoipati R. , et al. Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial. Lancet 2009; 374 (9698): 1351-1363
  • 21 Combes A, Bacchetta M, Brodie D, Müller T, Pellegrino V. Extracorporeal membrane oxygenation for respiratory failure in adults. Curr Opin Crit Care 2012; 18 (01) 99-104
  • 22 Harvey MJ, Gaies MG, Prosser LA. U.S. and international in-hospital costs of extracorporeal membrane oxygenation: a systematic review. Appl Health Econ Health Policy 2015; 13 (04) 341-357
  • 23 Chiu R, Pillado E, Sareh S, De La Cruz K, Shemin RJ, Benharash P. Financial and clinical outcomes of extracorporeal mechanical support. J Card Surg 2017; 32 (03) 215-221
  • 24 Barrett KA, Hawkins N, Fan E. Economic evaluation of venovenous extracorporeal membrane oxygenation for severe acute respiratory distress syndrome. Crit Care Med 2019; 47 (02) 186-193
  • 25 Iwashyna TJ, Ely EW, Smith DM, Langa KM. Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA 2010; 304 (16) 1787-1794
  • 26 Herridge MS, Cheung AM, Tansey CM. , et al. One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med 2003; 348 (08) 683-693
  • 27 Herridge MS, Tansey CM, Matté A. , et al. Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med 2011; 364 (14) 1293-1304
  • 28 Ruhl AP, Huang M, Colantuoni E. , et al. Healthcare utilization and costs in ARDS survivors: a 1-year longitudinal national US multicenter study. Intensive Care Med 2017; 43 (07) 980-991
  • 29 Unroe M, Kahn JM, Carson SS. , et al. One-year trajectories of care and resource utilization for recipients of prolonged mechanical ventilation: a cohort study. Ann Intern Med 2010; 153 (03) 167-175
  • 30 Pandharipande PP, Girard TD, Jackson JC. , et al. Long-term cognitive impairment after critical illness. N Engl J Med 2013; 369 (14) 1306-1316
  • 31 Kamdar BB, Sepulveda KA, Chong A. , et al. Return to work and lost earnings after acute respiratory distress syndrome: a 5-year prospective, longitudinal study of long-term survivors. Thorax 2018; 73 (02) 125-133
  • 32 Khandelwal N, Hough CL, Downey L. , et al. Prevalence, risk factors, and outcomes of financial stress in survivors of critical illness. Crit Care Med 2018; 46 (06) e530-e539
  • 33 Paoli CJ, Reynolds MA, Sinha M, Gitlin M, Crouser E. Epidemiology and costs of sepsis in the United States-an analysis based on timing of diagnosis and severity level. Crit Care Med 2018; 46 (12) 1889-1897
  • 34 Lee H, Doig CJ, Ghali WA, Donaldson C, Johnson D, Manns B. Detailed cost analysis of care for survivors of severe sepsis. Crit Care Med 2004; 32 (04) 981-985
  • 35 Jung K-T, Shin DW, Lee K-J, Oh M. Cost-effectiveness of recombinant tissue plasminogen activator in the management of acute ischemic stroke: a systematic review. J Clin Neurol 2010; 6 (03) 117-126
  • 36 Merchant RM, Becker LB, Abella BS, Asch DA, Groeneveld PW. Cost-effectiveness of therapeutic hypothermia after cardiac arrest. Circ Cardiovasc Qual Outcomes 2009; 2 (05) 421-428
  • 37 Noyes K, Veazie P, Hall WJ. , et al. Cost-effectiveness of cardiac resynchronization therapy in the MADIT-CRT trial. J Cardiovasc Electrophysiol 2013; 24 (01) 66-74
  • 38 Lee KH, Angus DC, Abramson NS. Cardiopulmonary resuscitation: what cost to cheat death?. Crit Care Med 1996; 24 (12) 2046-2052
  • 39 Rhodes A, Evans LE, Alhazzani W. , et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Crit Care Med 2017; 45 (03) 486-552
  • 40 Acute Respiratory Distress Syndrome Network, Brower RG, Matthay MA. , et al. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000; 342 (18) 1301-1308
  • 41 Girard TD, Kress JP, Fuchs BD. , et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial. Lancet 2008; 371 (9607): 126-134
  • 42 Pun BT, Balas MC, Barnes-Daly MA. , et al. Caring for critically ill patients with the ABCDEF bundle: results of the ICU liberation collaborative in over 15,000 adults. Crit Care Med 2019; 47 (01) 3-14
  • 43 Kahn JM, Werner RM, David G, Ten Have TR, Benson NM, Asch DA. Effectiveness of long-term acute care hospitalization in elderly patients with chronic critical illness. Med Care 2013; 51 (01) 4-10
  • 44 Kahn JM, Werner RM, Carson SS, Iwashyna TJ. Variation in long-term acute care hospital use after intensive care. Med Care Res Rev 2012; 69 (03) 339-350
  • 45 Herridge MS, Chu LM, Matte A. , et al. The RECOVER Program: disability risk groups and 1-year outcome after 7 or more days of mechanical ventilation. Am J Respir Crit Care Med 2016; 194 (07) 831-844
  • 46 Kahn JM, Le T, Angus DC. , et al. The epidemiology of chronic critical illness in the United States. Crit Care Med 2015; 43 (02) 282-287
  • 47 Carson SS, Garrett J, Hanson LC. , et al. A prognostic model for one-year mortality in patients requiring prolonged mechanical ventilation. Crit Care Med 2008; 36 (07) 2061-2069
  • 48 Carson SS, Cox CE, Wallenstein S. , et al. Effect of palliative care-led meetings for families of patients with chronic critical illness: a randomized clinical trial. JAMA 2016; 316 (01) 51-62
  • 49 Cox CE, White DB, Hough CL. , et al. Effects of a personalized web-based decision aid for surrogate decision makers of patients with prolonged mechanical ventilation: a randomized clinical trial. Ann Intern Med 2019 (e-pub ahead of print). Doi: 10.7326/M18-2335