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DOI: 10.1055/s-0039-1686542
vHIT as a screening method for detection of vestibular hypofunction after perinatal, systemic gentamicin therapy – preliminary results
Introduction:
The vestibulotoxic effect of aminoglycosides, especially gentamicin, has already been identified. Nevertheless gentamicin is a guideline-appropriate and potent medication for perinatal sepsis. Therefore, the aim of the present study was to assess a potential vestibulotoxic effect from perinatal gentamicin therapy in infants using the video head impulse test (vHIT).
Patients and methods:
Vestibular function was assessed using vHIT to evaluate horizontal semicircular canal function in 17 children who perinatally underwent a five-day intravenous therapy with gentamicin. Outcome measures included gain and the occurrence of refixational saccades.
Results:
All of the tested children revealed a normal gain in vHIT. Moreover, pathologic catch-up saccades could not be identified.
Conclusion:
Perinatal intravenous gentamicin therapy does not seem to cause a permanent vestibulotoxic effect in children. Nevertheless, further research in a larger cohort is needed to detect a possible vestibulotoxic effect.
Publikationsverlauf
Publikationsdatum:
23. April 2019 (online)
© 2019. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Georg Thieme Verlag KG
Stuttgart · New York