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CC BY-NC-ND 4.0 · Journal of Gastrointestinal and Abdominal Radiology 2019; 02(02): 130-134
DOI: 10.1055/s-0039-1689682
Case Report
Indian Society of Gastrointestinal and Abdominal Radiology

Crizotinib-Associated Renal Cysts: A Case Series

Garima Suman
1   Department of Radiology, Tata Memorial Center, Mumbai, Maharashtra, India
,
Anurima Patra
1   Department of Radiology, Tata Memorial Center, Mumbai, Maharashtra, India
,
Amit Janu
1   Department of Radiology, Tata Memorial Center, Mumbai, Maharashtra, India
,
Akshay Baheti
1   Department of Radiology, Tata Memorial Center, Mumbai, Maharashtra, India
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Publikationsverlauf

Received: 31. Januar 2019

Accepted after revision: 27. Februar 2019

Publikationsdatum:
19. Juli 2019 (online)

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Abstract

Crizotinib is an anaplastic lymphoma kinase (ALK) inhibitor, used as a targeted chemotherapeutic agent in ALK-positive cases of nonsmall cell lung carcinoma. Although uncommon, it may be associated with the formation of new renal cysts, which may be simple or complex, or the enlargement of preexisting simple renal cysts or their transformation into complex cysts. These cysts usually regress partially or completely but may rarely enlarge over time or get complicated by infection or abscess formation. Such cases may even require dose reduction or withholding crizotinib. Although documented in clinical literature, this entity is not well known among radiologists. Knowledge of this entity helps in preventing erroneous diagnosis of the new kidney “lesion” as metastasis or disease progression and avoids an unnecessary biopsy. We describe a series of four cases which developed complex renal cysts during treatment with crizotinib to demonstrate this point.

Keywords

crizotinib-associated renal cyst - anaplastic lymphoma kinase - nonsmall-cell lung cancer - complex cyst
 

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