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Synthesis 2020; 52(04): 529-536
DOI: 10.1055/s-0039-1690014
DOI: 10.1055/s-0039-1690014
paper
Allylic C–H Alkynylation via Copper-Photocatalyzed Cross-Dehydrogenative Coupling
Financial support by the German Academic Exchange Service, DAAD (Leadership for Syria Program) is gratefully acknowledged.Further Information
Publication History
Received: 30 April 2019
Accepted after revision: 18 July 2019
Publication Date:
25 July 2019 (online)
Published as part of the Bürgenstock Special Section 2019 Future Stars in Organic Chemistry
Abstract
An efficient, novel photocatalyzed allylic-alkynylation methodology via copper-based cross-dehydrogenative coupling (CDC) is described. Different types of 1,4-enyne compounds were synthesized in one step at room temperature using copper(I) terpyridyl complex as photocatalyst/initiator. This procedure is an improvement and to some extent complementary to previously reported thermal CDC methods. Preliminary investigations on the reaction mechanism are also presented.
Key words
C–C bond - copper catalyst - C–H functionalization - photocatalyst - allylic-alkynylation - 1,4-enyneSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690014.
- Supporting Information
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