Synthesis, Inhaltsverzeichnis Synthesis 2020; 52(04): 537-543DOI: 10.1055/s-0039-1690016 paper © Georg Thieme Verlag Stuttgart · New York Solid-Phase Zincke Reaction for the Synthesis of Peptide-4,4′-bipyridinium Conjugates Pablo Cortón , Paula Novo , Vanesa López-Sobrado , Marcos D. García , Carlos Peinador ∗ , Elena Pazos ∗ Departamento de Química, Facultade de Ciencias and Centro de Investigacións Científicas Avanzadas (CICA), Universidade da Coruña, 15071 A Coruña, Spain eMail: elena.pazos@udc.es › Institutsangaben Artikel empfehlen Abstract Artikel einzeln kaufen Alle Artikel dieser Rubrik Published as part of the Bürgenstock Special Section 2019 Future Stars in Organic Chemistry Abstract We present herein the development of a new synthetic strategy for the conjugation of 4,4′-bipyridinium derivatives into peptide scaffolds. The methodology, based on the development of a solid-phase version of the Zincke reaction between activated pyridinium salts and amines, is able to produce the desired conjugates in a straightforward fashion, with the bipyridinium units attached at the N-terminus of peptides or at Lys side chains of N-terminal acetylated peptides. Key words Key wordspeptide-based conjugates - viologens - Zincke reaction - solid phase peptide synthesis (SPPS) - synthetic methodology Volltext Referenzen References 1 Both authors contributed equally to this work. 2a Vinogradov AA, Yin Y, Suga H. J. Am. Chem. Soc. 2019; 141: 4167 2b Torres MD. T, Sothiselvam S, Lu TK, de la Fuente-Núñez C. J. Mol. Biol. 2019; 431: in press; DOI: 10.1016/j.jmb.2018.12.015 3a Liu Q, Wang J, Boyd BJ. Talanta 2015; 136: 114 3b González-Vera JA. Chem. Soc. Rev. 2012; 41: 1652 3c Pazos E, Vázquez O, Mascareñas JL, Vázquez ME. Chem. Soc. Rev. 2009; 38: 3348 4a Li J, Xing R, Bai S, Yan X. 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