Recent Developments in Highly Stereoselective Michael Addition Reactions Catalyzed by Metal Complexes

Alexander N. Reznikov; Yuri N. Klimochkin

doi:10.1055/s-0039-1690044

Synthesis, Table of Contents

Synthesis 2020; 52(06): 781-795
DOI: 10.1055/s-0039-1690044

review

Recent Developments in Highly Stereoselective Michael Addition Reactions Catalyzed by Metal Complexes

Alexander N. Reznikov ∗

Department of Organic Chemistry, Samara State Technical University, Samara 443100, Molodogwardeyskaya st. 244, Russian Federation Email: reznikov.an@samgtu.ru

,

Yuri N. Klimochkin

› Author Affiliations

Abstract

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Abstract

Achieving high enantioselectivity and diastereoselectivity simultaneously is a rather challenging task for asymmetric catalytic synthesis. Thanks to the rapid development of asymmetric transition-metal catalysis, significant progress has been made during recent years in achieving highly enantio- and diastereoselective conjugate addition reactions with a diverse combination of Michael donors and acceptors. This short review surveys the advances in transition-metal-catalyzed asymmetric diastereoselective Michael addition including diastereodivergent catalysis developed between 2015 and 2019. The review is divided into multiple parts according to the type of nucleophiles involved in the reaction.

1 Introduction

2 Addition of Functionalized Ketones and Dicarbonyl Compounds

3 Addition of Aldimino Esters and Their Cyclic Analogues

4 Addition of Indolin-2-ones

5 Vinylogous Michael Reactions

6 Other Michael Donors

7 Cascade Reactions Initiated by Michael Addition

8 Conclusion

Key words

Michael addition - asymmetric catalysis - enantioselectivity - diastereoselectivity - transition-metal complexes

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References

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