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Synthesis 2020; 52(08): 1203-1210
DOI: 10.1055/s-0039-1690054
DOI: 10.1055/s-0039-1690054
feature
Oxidation of 4-Aryl-1,1,1-trifluorobut-2-en-2-yl Trifluoromethanesulfonates by 4-Picoline-N-Oxide: A Novel Approach to β-Trifluoromethyl-α,β-enones
Financial support for this work was provided by the National Natural Science Foundation of China (No. 21878037).Weitere Informationen
Publikationsverlauf
Received: 28. Oktober 2019
Accepted after revision: 19. Januar 2020
Publikationsdatum:
10. Februar 2020 (online)
Abstract
An efficient approach to β-trifluoromethyl-α,β-enones via oxidation of 4-aryl-1,1,1-trifluorobut-2-en-2-yl trifluoromethanesulfonates is described. The reaction proceeds smoothly under mild and metal-free conditions and tolerates a wide range of functional groups. Various β-trifluoromethyl-α,β-enones were obtained in moderate to good yields.
Key words
fluorine - enones - oxidation - β-trifluoromethyl-α,β-enones - 4-aryl-1,1,1-trifluorobut-2-en-2-yl trifluoromethanesulfonates - pyridine N-oxidesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690054.
- Supporting Information
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