Environmentally Friendly Nafion-Mediated Friedländer Quinoline Synthesis under Microwave Irradiation: Application to One-Pot Synthesis of Substituted Quinolinyl Chalcones

Chieh-Kai Chan; Chien-Yu Lai; Cheng-Chung Wang

doi:10.1055/s-0039-1690088

Synthesis, Table of Contents

Synthesis 2020; 52(12): 1779-1794
DOI: 10.1055/s-0039-1690088

paper

Environmentally Friendly Nafion-Mediated Friedländer Quinoline Synthesis under Microwave Irradiation: Application to One-Pot Synthesis of Substituted Quinolinyl Chalcones

Chieh-Kai Chan

,

Chien-Yu Lai

,

Cheng-Chung Wang∗

Abstract

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Abstract

An efficient and eco-friendly synthetic route for Friedländer quinoline synthesis of polysubstituted quinolines is described. This green chemical method starts from various 2-aminobenzophenones and mono- or dicarbonyl synthons and uses reusable Nafion NR50 material as a solid catalyst in ethanol under microwave irradiation. The protocol has a high generality of functional groups and provides the desired quinolines in good to excellent yields. Some structures were confirmed by single-crystal X-ray diffraction analysis.

Key words

Friedländer reaction - Nafion catalyst - quinolines - chalcone - microwave irradiation

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References

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