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Synthesis 2019; 51(19): 3736-3746
DOI: 10.1055/s-0039-1690127
DOI: 10.1055/s-0039-1690127
paper
Highly γ-Regioselective 1,2-Addition of α,β-Unsaturated Oxime Ethers with Allylzinc Bromides: A Straightforward Approach for the Synthesis of Homoallylic Amines
The study was supported by the National Natural Science Foundation of China (No. 21072143).Further Information
Publication History
Received: 24 March 2019
Accepted after revision: 21 June 2019
Publication Date:
11 July 2019 (online)
Abstract
A highly regioselective reaction between allylzinc bromide reagents and α,β-unsaturated oxime ethers for the one-step synthesis of the homoallylic amines is reported. This process is a regioselective 1,2-addition reaction providing a new γ-position with carbon–carbon bond formation. Furthermore, the reaction substrates are widely applicable and can be produced in a high yield.
Key words
regioselectivity - homoallylic amine - α,β-unsaturated oxime ether - organozinc reagent - 1,2-additionSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690127.
- Supporting Information
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