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Synthesis 2019; 51(24): 4645-4649
DOI: 10.1055/s-0039-1690683
DOI: 10.1055/s-0039-1690683
paper
Copper-Catalyzed Nitrogenation of Aromatic and Aliphatic Aldehydes: A Direct Route to Carbamoyl Azides
We thank the National Key R & D Program of China (Grant No. 2017YFA0700103), the NSFC (Grant Nos. 21602028, 21672213, 21871258), the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDB20000000), and the Haixi Institute of CAS (Grant No. CXZX-2017-P01) for financial support.Further Information
Publication History
Received: 24 July 2019
Accepted after revision: 01 September 2019
Publication Date:
23 September 2019 (online)
Abstract
An efficient copper-catalyzed synthesis of carbamoyl azides directly from aldehydes has been developed. Both aromatic aldehydes and aliphatic aldehydes, together with other commercially available reactants, can be used as substrates in this radical relay reaction. Broad substrate scope, simple operation, readily available reagents, and good functionality tolerance make this method very attractive.
Key words
copper catalyst - carbamoyl azides - aromatic aldehydes - aliphatic aldehydes - nitrogenation - radicalSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690683.
- Supporting Information
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