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Synthesis 2020; 52(02): 197-207
DOI: 10.1055/s-0039-1690714
DOI: 10.1055/s-0039-1690714
short review
Recent Advances in Difluoromethylthiolation
We thank the National Natural Science Foundation (21421002, 21672242), Key Research Program of Frontier Sciences, Chinese Academy of Sciences (QYZDJSSW-SLH049), and National Basic Research Program of China (2015CB931903), Hunan Graduate Science and Technology Innovation Projects (CX2018B585), the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (0223-0007-000004), the Undergraduate Research Learning and Innovative Experiment Project, University of South China (2019-100, 2018XJXZ188, 2018XJXZ350, 2018XJXZ194, 2018XJXZ351), the Guiding Project Of Hengyang Science and Technology Department (S2018F9031015299), Program for Innovative Talent Team of Hengyang (2017-1), the Key Project of Hengyang Science and Technology Department (2017KJ166) for financial support.Further Information
Publication History
Received: 10 July 2019
Accepted after revision: 26 September 2019
Publication Date:
21 October 2019 (online)
§ These authors contributed equally to this work.
Abstract
The difluoromethylthio group (HCF2S), which has been identified as a valuable functionality in drug and agrochemical discovery, has received increased attention recently. Two strategies, difluoromethylation and direct difluoromethylthiolation, have been well established for HCF2S incorporation. The former strategy suffers from the need to prepare sulfur-containing substrates. In contrast, direct difluoromethylthiolation is straightforward and step-economic. This short review covers the recent advances in direct difluoromethylthiolation, including electrophilic, radical, and transition-metal-catalyzed or -promoted reactions.
1 Introduction
2 Electrophilic Difluoromethylthiolation
3 Radical Difluoromethylthiolation
4 Transition-Metal-Catalyzed or -Promoted Difluoromethylthiolation
5 Conclusions and Perspectives
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