Recent Advances in Nickel-Catalyzed Three-Component Difunctionalization of Unactivated Alkenes

Hai-Yong Tu; Shengqing Zhu; Feng-Ling Qing; Lingling Chu

doi:10.1055/s-0039-1690842

Synthesis, Table of Contents

Synthesis 2020; 52(09): 1346-1356
DOI: 10.1055/s-0039-1690842

short review

Recent Advances in Nickel-Catalyzed Three-Component Difunctionalization of Unactivated Alkenes

Hai-Yong Tu

,

Shengqing Zhu∗

,

Feng-Ling Qing

,

Lingling Chu∗

College of Chemistry, Chemical Engineering and Biotechnology, Center for Advanced Low-Dimension Materials, Donghua University, Shanghai 201620, P. R. of China Email: zhusq@dhu.edu.cn Email: Lingling.chu1@dhu.edu.cn

› Author Affiliations

Abstract

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Abstract

Catalytic, intermolecular difunctionalization of alkenes represents an efficient and diverse protocol for the buildup of molecular complexity from abundant materials by forging two chemical bonds in a single operation. Despite important progress in this area, transition-metal-catalyzed three-component difunctionalization of unactivated alkenes remains underdeveloped, mainly because of the low reactivity, reduced polarization, and high tendency toward β-hydride elimination of these compounds. In this context, nickel-catalyzed, selective, intermolecular difunctionalization methods that generally proceed via two distinct reaction pathways, migratory insertion of nickel species into alkenes and radical addition to alkenes, have been developed. This short review highlights recent advances in this area.

1 Introduction

2 Nickel-Catalyzed Three-Component Difunctionalization of Unactivated Alkenes via Migratory Insertion Processes

3 Nickel-Catalyzed Three-Component Difunctionalization of Unactivated Alkenes via Radical Processes

4 Conclusions and Perspectives

Key words

nickel catalysis - difunctionalization - unactivated alkenes - migratory insertion - radical addition

Full Text

References

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