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Synthesis 2020; 52(08): 1273-1278
DOI: 10.1055/s-0039-1691588
DOI: 10.1055/s-0039-1691588
paper
Synthesis of Spirocyclic Amines by 1,3-Dipolar Cycloaddition of Azomethine Ylides and Azomethine Imines
This research was supported by the EPSRC, the University of Sheffield, and the Thai Government.Further Information
Publication History
Received: 09 December 2019
Accepted after revision: 21 December 2019
Publication Date:
27 January 2020 (online)
Abstract
Simple ketone starting materials with a halide leaving group and an alkene were prepared in one step and heated with glycine or glycine esters to promote a tandem imine formation, cyclization, and dipolar cycloaddition cascade. The chemistry was also feasible with acetylhydrazide. In each case a single stereoisomer of the tricyclic amine or pyrazolidine product was formed and the stereochemistry was verified by single crystal X-ray diffraction. When the reaction with glycine, which occurs with loss of CO2, was unsuccessful, the cascade process could be promoted by cross metathesis to give the vinyl sulfone starting material that provides a more reactive dipolarophile. Reductive cleavage of the pyrazolidine gave a spirocyclic diamine product.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1691588.
- Supporting Information
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