Microwave-Accelerated N-Acylation of Sulfoximines with Aldehydes under Catalyst-Free Conditions

Kamal K. Rajbongshi; Srinivas Ambala; Thavendran Govender; Hendrik G. Kruger; Per I. Arvidsson; Tricia Naicker

doi:10.1055/s-0039-1691589

Synthesis, Table of Contents

Synthesis 2020; 52(08): 1279-1286
DOI: 10.1055/s-0039-1691589

paper

Microwave-Accelerated N-Acylation of Sulfoximines with Aldehydes under Catalyst-Free Conditions

Authors

Kamal K. Rajbongshi

^aCatalysis and Peptide Research Unit, University of KwaZuluNatal, Durban, 4001, South Africa Email: naickert1@ukzn.ac.za
Srinivas Ambala

^aCatalysis and Peptide Research Unit, University of KwaZuluNatal, Durban, 4001, South Africa Email: naickert1@ukzn.ac.za
Thavendran Govender

^bDepartment of Chemistry, University of Zululand, Private Bag X1001, KwaDlangezwa 3886, South Africa
Hendrik G. Kruger

^aCatalysis and Peptide Research Unit, University of KwaZuluNatal, Durban, 4001, South Africa Email: naickert1@ukzn.ac.za
Per I. Arvidsson ∗

^aCatalysis and Peptide Research Unit, University of KwaZuluNatal, Durban, 4001, South Africa Email: naickert1@ukzn.ac.za

^cScience for Life Laboratory, Drug Discovery & Development Platform & Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden Email: Per.Arvidsson@scilifelab.se
Tricia Naicker ∗

^aCatalysis and Peptide Research Unit, University of KwaZuluNatal, Durban, 4001, South Africa Email: naickert1@ukzn.ac.za

Abstract

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Abstract

An efficient catalyst-free radical cross-coupling reaction between aromatic aldehydes and sulfoximines was developed. The reaction took place in the presence of N-bromosuccinimide as the radical initiator under microwave irradiation to afford the corresponding acylated sulfoximines in moderate to excellent yields (27 examples). This protocol proved to be rapid, easy to handle, and applicable to a broad scope of substrates.

Key words

acylation - radical reactions - sulfoximines - N-bromosuccinimide - microwave irradiation

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References

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Supplementary Material

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