Cascade Reactions to Substituted 1H-Pyrrole-3-carbonitriles via Ligand-Free Palladium(II)-Catalyzed C(sp)–C(sp2) Coupling

Zijuan Wang; Wenteng Chen; Haofan Luo; Chang He; Guolin Zhang; Yongping Yu

doi:10.1055/s-0039-1691731

Synthesis, Inhaltsverzeichnis

Synthesis 2020; 52(11): 1659-1665
DOI: 10.1055/s-0039-1691731

paper

Cascade Reactions to Substituted 1H-Pyrrole-3-carbonitriles via Ligand-Free Palladium(II)-Catalyzed C(sp)–C(sp²) Coupling

Zijuan Wang

,

Wenteng Chen

,

Haofan Luo

,

Chang He

,

Guolin Zhang∗

,

Yongping Yu∗

Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, P. R. of China eMail: guolinzhang@zju.edu.cn eMail: yyu@zju.edu.cn

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Abstract

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Abstract

An efficient and simple synthesis of substituted 1H-pyrrole-3-carbonitriles was developed. This reaction is a palladium(II)-catalyzed cascade of C(sp)–C(sp²) coupling followed by intramolecular C–N bond formation. The method can tolerate various substrates with satisfactory yields. Its ligand-free conditions and high efficiency make this method particularly attractive.

Key words

C–C coupling - palladium - ligand-free - cascade reactions - substituted 1H-pyrrole-3-carbonitriles

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