Reply to the Letter: ‘Homeopathy and Nanomedicine: Alien Twins’

E. S. Rajendran

doi:10.1055/s-0039-1693155

Homeopathy, Table of Contents

Homeopathy 2019; 108(04): 296-297
DOI: 10.1055/s-0039-1693155

Letter to the Editor

The Faculty of Homeopathy

Reply to the Letter: ‘Homeopathy and Nanomedicine: Alien Twins’

E. S. Rajendran

¹Department of Homeopathic Philosophy, Vinayaka Mission’s Homeopathic Medical College and Hospital, Tamil Nadu, Salem, India

› Author Affiliations

Abstract

Full Text

References

References
1 Farvadi F, Hashemi F. Homeopathy and nanomedicine: Alien twins. Homeopathy 2019; 108: 294-295
2 Rajendran ES. Homeopathy seen as personalised nanomedicine. Homeopathy 2019; 108: 66-70
3 Rutten L, Mathie RT, Fisher P, Goossens M, van Wassenhoven M. Plausibility and evidence: the case of homeopathy. Med Health Care Philos 2013; 16: 525-532
4 Rajendran ES. Nano pharmacological aspect of homeopathic drugs – a comparative study of different scales of ultra-high dilutions based on HRTEM analysis and NP characterization of homeopathic drug Natrum muriaticum 6C-CM and LM1–LM30. Saudi J Med Pharm Sci 2017; 3: 89-106
5 Chikramane PS, Suresh AK, Bellare JR, Kane SG. Extreme homeopathic dilutions retain starting materials: a nanoparticulate perspective. Homeopathy 2010; 99: 231-242
6 Bell IR, Muralidharan S, Schwartz GE. Nanoparticle characterization of traditional homeopathically - manufactured Gelsemium sempervirens medicines and placebo controls. J Nanomedine Biotherapeutic Discov 2015; 5: 136
7 Bell IR, Muralidharan S, Schwartz GE. Nanoparticle characterization of traditional homeopathically - manufactured Silver (Argentum metallicum) medicines and placebo controls. J Nanomed Nanotechnol 2015; 6: 311
8 Bell IR, Schwartz GE. Enhancement of adaptive biological effects by nanotechnology preparation methods in homeopathic medicines. Homeopathy 2015; 104: 123-138
9 Upadhyay RP, Nayak C. Homeopathy emerging as nanomedicine. Int J High Dilution Res 2011; 10: 299-310
10 Konovalov AI, Ryzhkina IS. Highly diluted aqueous solutions: formation of nano-sized molecular assemblies (nanoassociates). Geochem Int 2014; 52: 1207-1226
11 Nandy P. A review of basic research on homeopathy from a physicist's point of view. Indian J Res Homeopathy 2015; 9: 141-151
12 Khuda-Bukhsh AR. Potentized homeopathic drugs act through regulation of gene expression: a hypothesis to explain their mechanism and pathways of action in vitro. Complement Ther Med 1997; 5: 43-46
13 Khuda-Bukhsh AR, Bhattacharya SS, Paul S. PLGA Nanoparticle encapsulated plant extract (Gelsemium sempervirens) enhances cellular uptake and increases bioactivity: novel findings from an in vitro study. Tsitol Genet 2009; 14: 15-18
14 Samadder A, Das S, Das J, Paul A, Boujedaini N, Khuda-Bukhsh AR. The potentized homeopathic drug, Lycopodium clavatum (5C and 15C) has anti-cancer effect on HeLa cells in vitro. J Acupunct Meridian Stud 2013; 6: 180-187
15 Mondal J, Panigrahi AK, Khuda-Bukhsh AR. Anticancer potential of Conium maculatum extract against cancer cells in vitro: drug-DNA interaction and its ability to induce apoptosis through ROS generation. Pharmacogn Mag 2014; 10 (Suppl. 03) S524-S533
16 Khuda-Bukhsh AR. Current trends in high dilution research with particular reference to gene regulatory hypothesis. Nucleus 2014; 57: 3-17
17 Samadder A, Khuda-Bukhsh AR. Nanotechnological approaches in diabetes treatment: A new horizon. World J Transl Med 2014; 3: 84-95
18 Saha SK, Roy S, Khuda-Bukhsh AR. Ultra-highly diluted plant extracts of Hydrastis canadensis and Marsdenia condurango induce epigenetic modifications and alter gene expression profiles in HeLa cells in vitro. J Integr Med 2015; 13: 400-411
19 Mandal SK, Biswas R, Bhattacharyya SS. , et al. Lycopodine from Lycopodium clavatum extract inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. Eur J Pharmacol 2010; 626: 115-122
20 Khuda-Bukhsh AR. Towards understanding molecular mechanisms of action of homeopathic drugs: an overview. Mol Cell Biochem 2003; 253: 339-345
21 Khuda-Bukhsh AR, Karmakar SR, Banerjee A. , et al. A follow-up study on the efficacy of the homeopathic remedy Arsenicum album in volunteers living in high risk Arsenic contaminated areas. Indian J Res Homeopathy 2009; 3: 43-51
22 Khuda-Bukhsh AR, Sikdar S. Condurango 30C induces epigenetic modification of lung cancer-specific tumour suppressor genes via demethylation. Forsch Komplement Med 2015; 22: 172-179
23 Khuda-Bukhsh AR, Bhattacharyya SS, Paul S, Dutta S, Boujedaini N, Belon P. Modulation of signal proteins: a plausible mechanism to explain how a potentized drug Secale cor 30C diluted beyond Avogadro's limit combats skin papilloma in mice. Evid Based Complement Alternat Med 2011; 2011: 286320
24 Das D, De A, Dutta S, Biswas R, Boujedaini N, Khuda-Bukhsh AR. Potentized homeopathic drug Arsenicum Album 30C positively modulates protein biomarkers and gene expressions in Saccharomyces cerevisiae exposed to arsenate. Zhong Xi Yi Jie He Xue Bao 2011; 9: 752-760
25 Khuda-Bukhsh AR, Chakrabarti J. Effects of sonication on chromosomes of mice, Mus musculus, and modifying effects of a homeopathic drug, Arnica Montana on them. Tsitol Genet 1998; 9: 333-340
26 Khuda-Bukhsh AR. An evidence-based evaluation of efficacy of homeopathic drugs in mice during induced hepatocarcinogenesis. Tsitol Genet 2007; 13: 177-185
27 Khuda-Bukhsh AR, De A, Das D, Dutta S, Boujedaini N. Analysis of the capability of ultra-highly diluted glucose to increase glucose uptake in arsenite-stressed bacteria Escherichia coli. Zhong Xi Yi Jie He Xue Bao 2011; 9: 901-912
28 Marzotto M, Olioso D, Brizzi M, Tononi P, Cristofoletti M, Bellavite P. Extreme sensitivity of gene expression in human SH-SY5Y neurocytes to ultra-low doses of Gelsemium sempervirens. BMC Complement Altern Med 2014; 14: 104-124
29 Sunila ES, Kuttan R, Preethi KC, Kuttan G. Dynamized preparations in cell culture. Evid Based Complement Alternat Med 2009; 6: 257-263
30 Preethi K, Ellanghiyil S, Kuttan G, Kuttan R. Induction of apoptosis of tumor cells by some potentiated homeopathic drugs: implications on mechanism of action. Integr Cancer Ther 2012; 11: 172-182
31 Mukherjee A, Sikdar S, Bishayee K, Boujedaini N, Khuda-Bukhsh AR. Flavonol isolated from ethanolic leaf extract of Thuja occidentalis arrests the cell cycle at G2-M and induces ROS-independent apoptosis in A549 cells, targeting nuclear DNA. Cell Prolif 2014; 47: 56-71
32 Bishayee K, Chakraborty D, Gosh D, Boujedaini N, Khuda-Bukhsh AR. Lycopodine triggers apoptosis by modulation 5-lipoxygenase, and depolarizing mitochondrial membrane potential in androgen sensitive and refractory prostate cancer cells without modulating p53 activity; signaling cascade and drug-DNA interaction. Eur J Pharmacol 2013; 698: 110-121
33 Bishayee K, Paul A, Ghosh S. , et al. Condurango-glycoside-A fraction of Gonolobus condurango induces DNA damage associated senescence and apoptosis via ROS-dependent p53 signalling pathway in HeLa cells. Mol Cell Biochem 2013; 382: 173-183
34 Friso S, Choi SW, Girelli D. , et al. A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci U S A 2002; 99: 5606-5611
35 Baylin SB, Herman JG, Graff JR, Vertino PM, Issa JP. Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res 1998; 72: 141-196
36 Olsen S. Effects of ultra-high dilutions of sodium butyrate on viability and gene expression in HEK 293 cells. Homeopathy 2017; 106: 32-36