MicroRNAs as Regulators and Biomarkers of Platelet Function and Activity in Coronary Artery Disease

Stefan Stojkovic; Anne Yaël Nossent; Paul Haller; Bernhard Jäger; Kris G. Vargas; Johann Wojta; Kurt Huber

doi:10.1055/s-0039-1693702

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2019; 119(10): 1563-1572
DOI: 10.1055/s-0039-1693702

Theme Issue Article

Georg Thieme Verlag KG Stuttgart · New York

MicroRNAs as Regulators and Biomarkers of Platelet Function and Activity in Coronary Artery Disease

Stefan Stojkovic

¹University Clinic for Internal Medicine II, Department of Cardiology, Medical University of Vienna, Vienna, Austria

,

Anne Yaël Nossent

¹University Clinic for Internal Medicine II, Department of Cardiology, Medical University of Vienna, Vienna, Austria

,

Paul Haller

²3rd Department of Internal Medicine, Cardiology, Intensive Care Medicine and Chest Pain Unit, Wilhelminenhospital, Vienna, Austria

,

Bernhard Jäger

²3rd Department of Internal Medicine, Cardiology, Intensive Care Medicine and Chest Pain Unit, Wilhelminenhospital, Vienna, Austria

³Medical Faculty, Sigmund Freud University, Vienna, Austria

,

Kris G. Vargas

²3rd Department of Internal Medicine, Cardiology, Intensive Care Medicine and Chest Pain Unit, Wilhelminenhospital, Vienna, Austria

,

Johann Wojta

¹University Clinic for Internal Medicine II, Department of Cardiology, Medical University of Vienna, Vienna, Austria

⁴Core Facilities, Medical University of Vienna, Vienna, Austria

⁵Ludwig Boltzmann Cluster for Cardiovascular Research, Vienna Austria

,

Kurt Huber

²3rd Department of Internal Medicine, Cardiology, Intensive Care Medicine and Chest Pain Unit, Wilhelminenhospital, Vienna, Austria

³Medical Faculty, Sigmund Freud University, Vienna, Austria

› Author Affiliations

Abstract

Microribonucleic acids (miRs) are small, noncoding ribonucleic acids (RNAs), which play an important role in the regulation of platelet function and activity. Several studies proposed a mechanistic role of platelet-related miRs in the pathophysiology of coronary artery disease (CAD) and atherothrombosis. Circulating, platelet-related miRs have been proposed as diagnostic, prognostic, as well as treatment response biomarkers in CAD and acute coronary syndrome (ACS). In this review, we summarize recent studies on the role of platelet-related miRs in the regulation of platelet function and activity. Furthermore, we review the studies investigating the role of platelet-related miRs as biomarkers in patients with CAD and ACS.

Keywords

microRNA - platelet function - coronary artery disease - acute myocardial infarction - acute coronary syndrome

Full Text

References

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