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Eur J Pediatr Surg 2019; 29(04): 342-351
DOI: 10.1055/s-0039-1694746
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Gastroschisis: State of the Art in Translating Experimental Research to the Bedside

Lourenço Sbragia
1   Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
,
Rebeca Lopes Figueira
1   Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
,
Karina Miura da Costa
1   Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
,
Fábio Perecim Volpe
1   Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
› Author Affiliations
Further Information

Publication History

24 June 2019

08 July 2019

Publication Date:
19 August 2019 (online)

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Abstract

The survival rate of newborns with gastroschisis (GS) has been increasing in the past decades; however, the morbidity continues to be high, mainly related to the length of hospitalization due to disturbances of motility, absorption, and risk of intestinal infections. The development of basic research with the creation of experimental models has provided enormous advances in the understanding of the pathophysiology of the disease. These models allowed the study of the target genes involved in the embryology of the defect, the influence of the amniotic fluid, and the use of drugs and fetal therapies in an attempt to reduce the intestinal damage and to provide a rapid return of intestinal motility. Our aim was to describe the main GS models and the translational, historical impact of these research advances on the disease.

Keywords

gastroschisis - translational - research - experimental model
 

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