Z Gastroenterol 2019; 57(09): e225
DOI: 10.1055/s-0039-1695211
Pankreas
Akute und Chronische Pankreatitis: Von den Grundlagen bis zur Therapie: Donnerstag, 03. Oktober 2019, 14:15 – 15:51, Studio Terrasse 2.2 A
Georg Thieme Verlag KG Stuttgart · New York

Chronic Pancreatitis Prognosis Score (COPPS): preliminary results from a prospective multicenter, international validation study

A Garbe
1   Ludwig Maximilans Universität München (LMU), Medizinische Klinik und Poliklinik II, München, Deutschland
,
UM Mahajan
1   Ludwig Maximilans Universität München (LMU), Medizinische Klinik und Poliklinik II, München, Deutschland
,
T Kohlmann
2   Universitätsmedizin Greifswald, Institut für Community Medicine, Greifswald, Deutschland
,
E Goni
1   Ludwig Maximilans Universität München (LMU), Medizinische Klinik und Poliklinik II, München, Deutschland
,
C Budde
3   Universitätsmedizin Greifswald, Klinik für Innere Medizin A, Greifswald, Deutschland
,
E Martinez-Moneo
4   Hospital Universitario de Cruces, Bilbao, Spanien
,
T Shimosegawa
5   Tohoku University, Sendai, Japan
,
C Forsmark
6   University of Florida, Gainsville, Vereinigte Staaten von Amerika
,
P Garg
7   All India Institute Of Medical Sciences, New Delhi, Indien
,
A Gomez
8   Hospital Prof. Dr. Fernando Fonseca, Servico de Cirurgia B, Amadora, Portugal
,
S Stigliona
9   II Medical School, University La Sapienza, Digestive and Liver Disease Unit, Rom, Italien
,
D Conwell
10   The Ohio State University, Wexner Medical Center, Columbus, Vereinigte Staaten von Amerika
,
MM Lerch
3   Universitätsmedizin Greifswald, Klinik für Innere Medizin A, Greifswald, Deutschland
,
J Mayerle
1   Ludwig Maximilans Universität München (LMU), Medizinische Klinik und Poliklinik II, München, Deutschland
3   Universitätsmedizin Greifswald, Klinik für Innere Medizin A, Greifswald, Deutschland
,
G Beyer
11   Ludwig-Maximilians-Universität München, Medizinische Klinik und Poliklinik II, München, Deutschland
› Author Affiliations
Further Information

Publication History

Publication Date:
13 August 2019 (online)

Also available at
 

Introduction/Aim:

We have recently developed an easy to use dynamic multivariate scoring system for patients with chronic pancreatitis using BMI, pain, CRP, platelet count and HbA1c. COPPS allowed objective monitoring of disease severity, determining risk for readmission to hospital and potential length of hospital stay in a prospective development cohort and retrospective validation cohort, both recruited in Northern Germany and Denmark (Beyer G et al. Gastroenterology. 2017). The predictive performance of COPPS in a more diverse population of chronic pancreatitis patients is unknown. Here we aim to prospectively validate COPPS in an international cohort of chronic pancreatitis patients.

Methods:

We prospectively recruited 252 patients between 04/2016 and 01/2018 with chronic pancreatitis from 8 centers in Europe, Japan, India and North America. At baseline COPPS, demographics and etiological factors were recorded and patients were follow-up for one year. The primary end-point was number of readmissions to hospital and the combined length of all hospital stays during the follow-up period. The study was approved by IRB of all participating centers.

Results:

Of the 252 included patients 220 (26.4% female, median age at diagnosis 50 years, alcohol and idiopathic most common etiology) had full data available for analysis. Mean COPPS was 8.06 points (SD ± 1.84), with 46, 122 and 52 patients in the respective COPPS category A, B, C. Mean number of hospital admission during follow-up was 1.07 (SD ± 1.60) with a mean number of 9.63 days (SD ± 23.35) spent in hospital. COPPS showed good correlation with both primary endpoints (p < 0.01) for parametric and non-parametric testing. Patients with high COPPS category (B, C) had a significantly higher risk for readmission (p < 0.05). Regular bootstrapping with 1000 repeats excluded significant bias.

Conclusion:

COPPS reliably predicts risk for readmission in a large, prospective, international cohort of patients with chronic pancreatitis. This further supports the potential value of COPPS as a reliable grading tool for severity of chronic pancreatitis warranting its use in clinical routine and clinical research. Recruitment to this cohort will continue until a final number of 500 subjects is reached.