“Opening” The Mesenchymal Stem Cell Tool Box

Fares Zeidán-Chuliá; Mami Noda

doi:10.1055/s-0039-1697439

European Journal of Dentistry, Table of Contents

CC BY-NC-ND 4.0 · Eur J Dent 2009; 03(03): 240-249
DOI: 10.1055/s-0039-1697439

Original Article

Dental Investigation Society

“Opening” The Mesenchymal Stem Cell Tool Box

Authors

Fares Zeidán-Chuliá

^aMedical Biochemistry and Developmental Biology, Institute of Biomedicine, University of Helsinki, Finland
Mami Noda

^bLaboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan

Abstract

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ABSTRACT

Adult mesenchymal stem cells (MSCs) are adherent stromal cells able to self-renew and differentiate into a wide variety of cells and tissues. MSCs can be obtained from distinct tissue sources and have turned out to be successfully manipulated in vitro. As adult stem cells, MSCs are less tumorigenic than their embryonic correlatives and posses another unique characteristic which is their almost null immunogenicity. Moreover, these cells seem to be immunosuppressive in vitro. These facts together with others became MSCs a promising subject of study for future approaches in bioengineering and cell-based therapy. On the other hand, new strategies to achieve long-term integration as well as efficient differentiation of these cells at the area of the lesion are still challenging, and the signalling pathways ruling these processes are not completely well characterized. In this review, we are going summarize the general landscape and current status of the MSC tool as well as their wide potential in tissue engineering, from neuronal to tooth replacement. Highlights and pitfalls for further clinical applications will be discussed. (Eur J Dent 2009;3:240-249)

Key words:

Adult mesenchymal stem cell - Dental pulp - Differentiation - Cell-based therapy - Tissue engineering - Tooth replacement

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References

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