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J Neurol Surg A Cent Eur Neurosurg 2020; 81(05): 418-422
DOI: 10.1055/s-0039-1698389
Original Article

Malignant “Angioglioma”: Clinical, Radiologic, and Histopathologic Features

Thomas Linsenmann
1   Department of Neurosurgery, University Hospital Wuerzburg, Wuerzburg, Germany
,
Thomas Westermaier
1   Department of Neurosurgery, University Hospital Wuerzburg, Wuerzburg, Germany
,
Camelia Monoranu
2   University of Wuerzburg, Neuropathology, Wuerzburg, Germany
,
Franco Amaya
3   Julius-Maximilians-Universitat Wurzburg, Neuroradiology, Wurzburg, Bayern, Germany
,
Almuth Keßler
1   Department of Neurosurgery, University Hospital Wuerzburg, Wuerzburg, Germany
,
Ralf Ingo Ernestus
1   Department of Neurosurgery, University Hospital Wuerzburg, Wuerzburg, Germany
,
Mario Löhr
1   Department of Neurosurgery, University Hospital Wuerzburg, Wuerzburg, Germany
,
Christian Stetter
1   Department of Neurosurgery, University Hospital Wuerzburg, Wuerzburg, Germany
› Author Affiliations
Source of Funding This work was funded by the German Research Foundation (DFG) and the University of Wuerzburg in the funding program Open Access Publishing.
› Further Information
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Abstract

Background Glioblastoma multiforme (GBM) is the most frequent malignant neoplasm in the adult brain. In contrast, arteriovenous malformations (AVMs) are presumably congenital lesions, usually presenting with hemorrhage. Hypervascular low-grade gliomas associated with AVMs were previously called “angioglioma.” An association of AVMs and GBM was also described.

Study Aims We discuss the data of the largest series of locally coincident GBM with AVM in a single institution so far. All analyses were explorative only.

Patients We report a series of four patients presenting at our department from 2006 to 2014. All patients underwent surgery. The cases were analyzed regarding initial presentation, clinical findings, tumor localization, and histopathologic results.

Conclusions A local coincidence of cerebral AVM and GBM is rare. Only a few reports can be found in the literature. The radiologic as well as the clinical presentations are individual. Proangiogenic factors are discussed as involved in the appearance of both entities in the same location. However, the presence of pathologic vessels within malignant gliomas is well known to all neurosurgeons and proangiogenic activity has been proven. Therefore, it seems possible that tumor activity itself contributes to the pathogenesis of a vascular malformation.

Keywords

angioglioma - glioma - arteriovenous malformation - glioblastoma multiforme - arteriovenous malformation/glioblastoma coincidence


Publication History

Received: 18 September 2018

Accepted: 06 June 2019

Article published online:
21 January 2020

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