Polymorphism in MTHFR (at SNPs 677 and 1298) in Paternal Sperm DNA and Risk of Retinoblastoma in their Children

Oxidative stress and polymorphism in MTHFR SNPs (677 and 1298) in paternal sperm DNA is associated with an increased risk of retinoblastoma in their children: a case-control study

We have read the paper “Oxidative stress and polymorphism in MTHFR SNPs (677 and 1298) in paternal sperm DNA is associated with an increased risk of retinoblastoma in their children: a case-control study.”[1] In fact, the effect of genetic polymorphism on retinoblastoma is interesting. Some polymorphisms are well studied for their association with retinoblastoma.[2] Previous reports have shown the relationship between MTHFR polymorphisms and retinoblastoma among patients.[3] This report is extraordinary since the investigation was not performed on a patient, but the genetic test was performed in paternal specimen. This is not a standard epidemiological investigation to assess the risk. There are several confounding factors such as material genetic component and environmental factors that can affect the final expression as retinoblastoma. To conclude on the association between MTHFR polymorphisms and retinoblastoma, additional study on samples from pediatric patients is required.

• References

• 1 Bisht S, Chawla B, Dada R. Oxidative stress and polymorphism in MTHFR SNPs (677 and 1298) in paternal sperm DNA is associated with an increased risk of retinoblastoma in their children: a case-control study. J Pediatr Genet 2018; 7 (03) 103-113
• 2 Thériault BL, Dimaras H, Gallie BL, Corson TW. The genomic landscape of retinoblastoma: a review. Clin Exp Ophthalmol 2014; 42 (01) 33-52
• 3 Soleimani E, Saliminejad K, Akbari MT, Kamali K, Ahani A. Association study of the common polymorphisms in the folate-methionine pathway with retinoblastoma. Ophthalmic Genet 2016; 37 (04) 384-387