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J Pediatr Genet 2020; 09(01): 019-026
DOI: 10.1055/s-0039-3399511
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Anthropometric and Metabolic Responses in FTO rs9939609 Gene Polymorphism after a Multidisciplinary Lifestyle Intervention in Overweight and Obese Adolescents

Cláudia Daniela Barbian 
1   Graduate Program in Health Promotion, University of Santa Cruz do Sul (UNISC), Santa Cruz do Sul, Rio Grande do Sul, Brazil
,
Cézane Priscila Reuter 
2   Department of Physical Education and Health, Graduate Program in Health Promotion, University of Santa Cruz do Sul (UNISC), Santa Cruz do Sul, Rio Grande do Sul, Brazil
,
Jane Dagmar Pollo Renner
3   Department of Biology and Pharmacy, Graduate Program in Health Promotion, University of Santa Cruz do Sul (UNISC), Santa Cruz do Sul, Rio Grande do Sul, Brazil
,
Priscila Tatiana da Silva 
1   Graduate Program in Health Promotion, University of Santa Cruz do Sul (UNISC), Santa Cruz do Sul, Rio Grande do Sul, Brazil
,
Elisa Inês Klinger 
1   Graduate Program in Health Promotion, University of Santa Cruz do Sul (UNISC), Santa Cruz do Sul, Rio Grande do Sul, Brazil
,
James Philip Hobkirk 
4   Department of Sport, Health and Exercise Sciences, Faculty of Health Sciences, School of Life Sciences, University of Hull, Hull, United Kingdom
,
Andréia Rosane de Moura Valim 
3   Department of Biology and Pharmacy, Graduate Program in Health Promotion, University of Santa Cruz do Sul (UNISC), Santa Cruz do Sul, Rio Grande do Sul, Brazil
,
Miria Suzana Burgos 
2   Department of Physical Education and Health, Graduate Program in Health Promotion, University of Santa Cruz do Sul (UNISC), Santa Cruz do Sul, Rio Grande do Sul, Brazil
› Author Affiliations
Further Information

Publication History

28 February 2019

25 September 2019

Publication Date:
07 November 2019 (online)

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Abstract

Few studies show the potential changing effect of fat-mass and obesity-associated (FTO) rs9939609 gene on cardiometabolic risk after a lifestyle intervention. This study aims to evaluate whether overweight and obese adolescents, carriers of the risk genotypes for obesity of the FTO rs9939609 gene polymorphism, have different anthropometric and biochemical responses to an interdisciplinary intervention program. The quasi-experimental study involved 34 adolescents aged 10 to 15 years. Schoolchildren with AA/AT genotype decreased glucose, total cholesterol, low-density lipoprotein cholesterol, and increased high-density lipoprotein cholesterol. However, there were no differences between the genotypes, suggesting that the “A” allele did not modify the subject's response to the intervention program.

Keywords

clinical trial - obesity - genetic polymorphism
 

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