Planta Med 2019; 85(18): 1403
DOI: 10.1055/s-0039-3399671
Abstracts of Plenary Lectures
© Georg Thieme Verlag KG Stuttgart · New York

The NCI program for natural product discovery

CC Thornburg
1   Natural Products Support Group, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research,, 21702, Frederick, MD USA
,
JR Britt
1   Natural Products Support Group, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research,, 21702, Frederick, MD USA
,
JR Evans
1   Natural Products Support Group, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research,, 21702, Frederick, MD USA
2   Data Management Services, Inc., Frederick National Laboratory for Cancer Research,, 21702,Frederick, MD USA
,
RK Akee
1   Natural Products Support Group, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research,, 21702, Frederick, MD USA
,
JA Whitt
1   Natural Products Support Group, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research,, 21702, Frederick, MD USA
,
SK Trinh
1   Natural Products Support Group, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research,, 21702, Frederick, MD USA
,
MJ Harris
1   Natural Products Support Group, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research,, 21702, Frederick, MD USA
,
JR Thompson
1   Natural Products Support Group, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research,, 21702, Frederick, MD USA
,
TL Ewing
1   Natural Products Support Group, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research,, 21702, Frederick, MD USA
,
SM Shipley
1   Natural Products Support Group, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research,, 21702, Frederick, MD USA
,
PG Grothaus
3   Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute,, 21702, Frederick, MD USA
,
DJ Newman
3   Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute,, 21702, Frederick, MD USA
,
T Grkovic
1   Natural Products Support Group, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research,, 21702, Frederick, MD USA
,
BR O’Keefe
3   Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute,, 21702, Frederick, MD USA
4   Molecular Targets Program, Center for Cancer Research, National Cancer Institute,, 21702, Frederick, MD USA
› Author Affiliations
Further Information

Publication History

Publication Date:
20 December 2019 (online)

Also available at
 

The US National Cancer Institute’s Natural Product Repository is one of the world’s largest, most diverse collections of natural products containing over 230,000 unique extracts derived from plant, marine and microbial organisms that have been collected from biodiverse regions throughout the world. Importantly, this national resource is available to the research community for the screening of extracts and the isolation of bioactive natural products. However, despite the success of natural products in drug cancer discovery, compatibility issues that make crude natural product extracts challenging have reduced enthusiasm for the high-throughput screening (HTS) of crude natural product extract libraries in targeted assay systems. To address these limitations and make the NCI’s Natural Products Repository more amenable to HTS, we have initiated the prefractionation of extracts using an automated, high-throughput robotics platform capable of generating a library of 1,000,000 partially purified extracts. The talk will discuss this and other mechanisms to increase the utility of the NCI Natural Products Repository in cancer-related drug discovery.

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Fig. 1