Planta Med 2019; 85(18): 1440
DOI: 10.1055/s-0039-3399770
Main Congress Poster
Poster Session 1
© Georg Thieme Verlag KG Stuttgart · New York

A plant used in Mexican traditional medicine improves colitis due to regulation of antioxidant mechanisms

M Rodriguez-Canales
1   IPN Escuela Nacional de Ciencias Biológicas,, Ciudad de México, México
,
AD Nava-Torres
1   IPN Escuela Nacional de Ciencias Biológicas,, Ciudad de México, México
,
E Martínez-Galero
1   IPN Escuela Nacional de Ciencias Biológicas,, Ciudad de México, México
,
MA Rodriguez-Monroy
2   UNAM FES Iztacala,, Tlalnepantla, Estado de México, C.P. 54090
,
MM Canales-Martinez
2   UNAM FES Iztacala,, Tlalnepantla, Estado de México, C.P. 54090
› Author Affiliations
Further Information

Publication History

Publication Date:
20 December 2019 (online)

 

Cyrtocarpa procera, known as “Chupandilla” is a plant used for gastrointestinal problems in Mexican traditional medicine[1], [2] Not only ethnobotanical use of this plant has been reported, but antibacterial, antifungal and antioxidant properties had been described for Chupandilla’s extract [1]. It´s well known that oxidative stress is one of the most important factors for both progression and severity of colitis, due to an impairment of antioxidant defenses [3]. Here, we evaluated the antioxidant effect of Chupandilla’s methanolic extract in a DSS-induced colitis.

DSS dissolved in drinking water was used for colitis induction on female BALB/c mice.

Compared to untreated mice with colitis, mice with Chupandilla’s extract presented an increase in survival rate, less severe colitis symptoms like diarrhea, bleeding and weight-loss.

At microscopical level, Chupandilla’s extract greatly reduced loss of crypts architecture and cellular organization and inflammatory infiltrate.

In terms of oxidative stress, treated group with extract also showimprovements; antioxidant enzymes likeno loss of activity in colon, while mice presented considerable low activities. Chupandilla’s extract prevented activity dual role in both inflammatory and oxidative stress processes during colitis.

C. procera extract, presented good in vitro antioxidant capacity, probably due to the presence of polyphenolic compounds, in particular flavonoids, which had been reported anti-inflammatory and antioxidant activities. Crhysin, naringenin, kaempferol and catequin were the flavonoids identified in C. procera extract. Thus, the improvement of UCcould be mechanisms of compounds.

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  • References

  • 1 Canales M, Hernandez T, Caballero J, Romo de Vivar A, Avila G, Duran A. et al. Informant consensus factor and antibacterial activity of the medicinal plants used by the people of San Rafael Coxcatlan, Puebla, Mexico. J Ethnopharmacol 2005; 97: 429-439
  • 2 Hersch-Martínez P. Commercialization of wild medicinal plants from southwest Puebla, Mexico. Econ Bot 1995; 49: 197-206
  • 3 Moura FA, de Andrade KQ, dos Santos JC, Araujo OR, Goulart MO. Antioxidant therapy for treatment of inflammatory bowel disease: Does it work?. Redox Biol 2015; 6: 617-639