Planta Med 2019; 85(18): 1463-1464
DOI: 10.1055/s-0039-3399835
Main Congress Poster
Poster Session 1
© Georg Thieme Verlag KG Stuttgart · New York

Investigation of the phytochemical profiles of Boronella spp (Rutaceae) using molecular networking

M Kritsanida
1   Laboratoire de Pharmacognosie, UMR/CNRS 8038 Cibles Thérapeutiques et Conception de Médicaments, Université de Paris,, Sorbonne Paris Cité, Faculté de Pharmacie de Paris, 4 avenue de l’Observatoire, 75006, Paris, France
,
M Graziani
1   Laboratoire de Pharmacognosie, UMR/CNRS 8038 Cibles Thérapeutiques et Conception de Médicaments, Université de Paris,, Sorbonne Paris Cité, Faculté de Pharmacie de Paris, 4 avenue de l’Observatoire, 75006, Paris, France
,
E Karachaliou
1   Laboratoire de Pharmacognosie, UMR/CNRS 8038 Cibles Thérapeutiques et Conception de Médicaments, Université de Paris,, Sorbonne Paris Cité, Faculté de Pharmacie de Paris, 4 avenue de l’Observatoire, 75006, Paris, France
,
M Litaudon
2   Institut de Chimie des Substances Naturelles, CNRS-ICSN, UPR 2301, Université Paris-Saclay,, 1, avenue de la Terrasse, 91198 Gif-sur-Yvette, France
,
MA Beniddir
3   Équipe “Pharmacognosie-Chimie des Substances Naturelles” BioCIS, Univ. Paris-Sud, CNRS, Université Paris-Saclay,, 5 Rue J.-B. Clément, 92290 Châtenay-Malabry, France
,
R Grougnet
1   Laboratoire de Pharmacognosie, UMR/CNRS 8038 Cibles Thérapeutiques et Conception de Médicaments, Université de Paris,, Sorbonne Paris Cité, Faculté de Pharmacie de Paris, 4 avenue de l’Observatoire, 75006, Paris, France
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Publikationsdatum:
20. Dezember 2019 (online)

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Recently, the genus Boronella (Rutaceae), endemic to New Caledonia and comprising four species, was transferred into Boronia on the basis of molecular phylogenetic analyses [1].

Nevertheless, chemical data on Boronella species are scarce. Quinolinone, furoquinoline, dihydrofuroquinoline, pyranoquinoline alkaloids along with koniamborine, an original pyrano[3,2b]indole and an isatine derivative have been described, together with coumarins, lignans and triterpenes [2]–[4].

In order to deeply explore the metabolome of this poorly studied section in the genus Boronia, LC-MS2 and molecular networking were applied. Aiming to identify unreported derivatives from the four following species, Boronia hartleyi (synonym Boronella crassifolia), Boronia koniambiensis (syn. Boronella koniambiensis), Boronia pancheri (syn. Boronella pancheri) and Boronia parvifolia (syn. Boronella parvifolia, Boronella verticillata), extracts from several plant parts were investigated.

After this step, purification of the methanolic stems and leaves extracts of B. koniambiensis was performed by a combination of centrifugal partition chromatography, HPLC and MPLC. Among others, the isolation and structure determination of an original coumarin, 3,5-dimethoxypsoralene, was succeeded, together with bergapten, two alkaloids (koniamborine, medicosmine) and three lignans (sesamin, (8R,8ʹR)-3-methoxy-3,4-methylenedioxy-9-9ʹ-epoxylignan-4ʹ-ol, S,S-(+)-dehydroxycubebin).

 

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