Planta Med 2019; 85(18): 1472
DOI: 10.1055/s-0039-3399856
Main Congress Poster
Poster Session 1
© Georg Thieme Verlag KG Stuttgart · New York

Antiproliferative property of sea fan extracts against colon (HCT116) and lung (A549) cancer cell lines

C Gelani
1   Department of Chemistry, Mindanao State University-Iligan Institute of Technology,, Iligan City, Philippines
,
KG Palubon
1   Department of Chemistry, Mindanao State University-Iligan Institute of Technology,, Iligan City, Philippines
,
CAF Galvez
1   Department of Chemistry, Mindanao State University-Iligan Institute of Technology,, Iligan City, Philippines
,
F Limbag
1   Department of Chemistry, Mindanao State University-Iligan Institute of Technology,, Iligan City, Philippines
› Author Affiliations
Further Information

Publication History

Publication Date:
20 December 2019 (online)

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The Philippines is endowed with rich marine resources, which, for the most part, is still untapped. This study explored the potential of the bioactive fractionsfrom sea fanswith the hope of finding potential drug candidates for cancer treatment. Sea fansamples were collected from the island of Mindanao, Philippines.Bioactivity-guided separation of polar and nonpolar extracts were done using colon (HCT116) and lung (A549) mammalian cancer cell lines employing the MTT assay. Chromatographic separation afforded a nonpolar (hexane) fraction of sea fan (coded DT03), which exhibited a percent cell viability of 30.06 ± 0.14 at 30 mcg/mL against HCT116. Its IC50 was calculated to be 54.51 ppm. Semi-purification of this extract is ongoing. Other sea fan polar and nonpolar extracts showed noncytotoxic to mildly cytotoxic activities against both colon and lung cancer cell lines. The antibacterial property determination of these extracts is the next phase of this study.

 

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