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DOI: 10.1055/s-0039-3399865
Chemical compositions from Biscogniauxia sp. PK15-040 fungus
Publication History
Publication Date:
20 December 2019 (online)
The genus Biscogniauxia, which was once a member of wood-decaying fungi Xylariaceae family, has been resurrected and has become a member of new Graphostromataceae family. This fungus is naturally found on the bark, trunks, and branches of shrubs and trees [1]-[3]. Unlike its previous co-family, Xylaria genus, only a few reports on natural products were published from B. spp. [3]-[4]. The objective of this research is to investigate the chemical compositions from Biscogniauxia sp. PK15-040 fungus collected from the Phu Khieo Wildlife Sanctuary, Thailand. The fungus was identified by its morphological characteristics and molecular data. It was cultivated in PDB medium for 6 weeks and purified by chromatographic methods. Its structures were established by the interpretation of spectroscopic data including 1D and 2D NMR, and IR.
Fifteen compounds were isolated and categorised into eight classes of compounds, including three guaiane sesquiterpenes, pogostol (1), xylaranone (2), and xylaranol B (3); two mellein derivatives, 3,5-dimethyl-8-hydroxy-3,4-dihydroisocoumarin (4) and 3,5-dimethyl-8-methoxy-3,4-dihydroisocoumarin (5); two pyrone derivatives (6-7); two cyclodipeptides (8-9); two isopimarane diterpenes (10-11); two steroids, ergosterol (12) and ergone (13); p-tyrosol (14) and a bergamotene derivative (15). The results indicate that Biscogniauxia sp. PK15-040 is an example of a marvellous source of diverse secondary metabolites and possibly diverse bioactive compounds, therefore we believe that B. spp. needs to be investigated further.
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References
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